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. 1989 Jan;86(2):612–616. doi: 10.1073/pnas.86.2.612

Identification and characterization of macrophage inflammatory protein 2.

S D Wolpe 1, B Sherry 1, D Juers 1, G Davatelis 1, R W Yurt 1, A Cerami 1
PMCID: PMC286522  PMID: 2643119

Abstract

In response to endotoxin, macrophages secrete a protein with a molecular mass of approximately 6000 Da and with an affinity for heparin. This protein, which we term "macrophage inflammatory protein 2," is a potent chemotactic agent for human polymorphonuclear leukocytes. In addition, subcutaneous administration of the monokine causes a localized inflammatory reaction. Partial N-terminal sequence data reveal similarity to a family of proteins, the archetype of which is platelet factor 4. Although macrophage inflammatory protein 2 is a distinct member of the platelet factor 4 family, its sequence is most closely related to that of the gro/KC gene product, which is expressed in transformed or platelet-derived growth factor-treated cells.

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Selected References

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