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. 1989 Feb;86(3):993–996. doi: 10.1073/pnas.86.3.993

Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection.

M C Wu 1, R D Shanks 1, H A Lewin 1
PMCID: PMC286605  PMID: 2536940

Abstract

Genetic potentials (pedigree-estimated breeding value) for milk and for fat were compared in cows grouped according to subclinical stage of bovine leukemia virus infection. Genetic potential for milk production was significantly greater in seropositive cows with persistent lymphocytosis (622 +/- 72 kg) and in seropositive hematologically normal cows (554 +/- 34 34 kg) than in seronegative herdmates (418 +/- 53 kg). When 305-day twice-daily-milking mature equivalent milk production records for the current lactation were adjusted for genetic potential, bovine leukemia virus-infected cows that were hematologically normal had significantly greater milk production than did seronegative herdmates, suggesting that early bovine leukemia virus infection was positively associated with milk yield. Genetic potential for fat production was significantly greater for cows with persistent lymphocytosis (21 +/- 2 kg) than for other seropositive (16 +/- 1 kg) and seronegative herdmates (13 +/- 2 kg); however, 305-day twice-daily-milking mature equivalent fat production for the current lactation was not significantly different between the groups. Thus, cows with persistent lymphocytosis did not produce fat according to their genetic potential. As an apparent consequence of tendencies for greater milk yield and less fat production, milk fat percentage was significantly reduced in cows with persistent lymphocytosis (3.33 +/- 0.09%) and other seropositive cows (3.48 +/- 0.05%) relative to seronegative herdmates (3.67 +/- 0.07%). These results suggest a need to reevaluate the economic impact of bovine leukemia virus infection on the dairy industry.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baumgartener L. E., Olson C., Miller J. M., Van Der Maaten M. J. Survey for antibodies to leukemia (C-type) virus in cattle. J Am Vet Med Assoc. 1975 Feb 1;166(3):249–251. [PubMed] [Google Scholar]
  2. Bex F., Bruck C., Mammerickx M., Portetelle D., Ghysdael J., Cleuter Y., Leclercq M., Dekegel D., Burny A. Humoral antibody response to bovine leukemia virus infection in cattle and sheep. Cancer Res. 1979 Mar;39(3):1118–1123. [PubMed] [Google Scholar]
  3. Eales L. J., Nye K. E., Parkin J. M., Weber J. N., Forster S. M., Harris J. R., Pinching A. J. Association of different allelic forms of group specific component with susceptibility to and clinical manifestation of human immunodeficiency virus infection. Lancet. 1987 May 2;1(8540):999–1002. doi: 10.1016/s0140-6736(87)92269-0. [DOI] [PubMed] [Google Scholar]
  4. Ferrer J. F., Marshak R. R., Abt D. A., Kenyon S. J. Persistent lymphocytosis in cattle: its cause, nature and relation to lymphosarcoma. Ann Rech Vet. 1978;9(4):851–857. [PubMed] [Google Scholar]
  5. Gupta P., Ferrer J. F. Comparison of various serological and direct methods for the diagnosis of BLV infection in cattle. Int J Cancer. 1981 Aug 15;28(2):179–184. doi: 10.1002/ijc.2910280211. [DOI] [PubMed] [Google Scholar]
  6. Huber N. L., DiGiacomo R. F., Evermann J. F., Studer E. Bovine leukemia virus infection in a large Holstein herd: prospective comparison of production and reproductive performance in antibody-negative and antibody-positive cows. Am J Vet Res. 1981 Sep;42(9):1477–1481. [PubMed] [Google Scholar]
  7. Kelley K. W. Stress and immune function: a bibliographic review. Ann Rech Vet. 1980;11(4):445–478. [PubMed] [Google Scholar]
  8. Kenyon S. J., Piper C. E. Cellular basis of persistent lymphocytosis in cattle infected with bovine leukemia virus. Infect Immun. 1977 Jun;16(3):891–897. doi: 10.1128/iai.16.3.891-897.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kettmann R., Cleuter Y., Mammerickx M., Meunier-Rotival M., Bernardi G., Burny A., Chantrenne H. Genomic integration of bovine leukemia provirus: comparison of persistent lymphocytosis with lymph node tumor form of enzootic. Proc Natl Acad Sci U S A. 1980 May;77(5):2577–2581. doi: 10.1073/pnas.77.5.2577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Langston A., Ferdinand G. A., Ruppanner R., Theilen G. H., Drlica S., Behymer D. Comparison of production variables of bovine leukemia virus antibody-negative and antibody-positive cows in two California dairy herds. Am J Vet Res. 1978 Jul;39(7):1093–1098. [PubMed] [Google Scholar]
  11. Lewin H. A., Bernoco D. Evidence for BoLA-linked resistance and susceptibility to subclinical progression of bovine leukaemia virus infection. Anim Genet. 1986;17(3):197–207. doi: 10.1111/j.1365-2052.1986.tb03191.x. [DOI] [PubMed] [Google Scholar]
  12. Lewin H. A., Wu M. C., Nolan T. J., Stewart J. A. Peripheral B lymphocyte percentage as an indicator of subclinical progression of bovine leukemia virus infection. J Dairy Sci. 1988 Sep;71(9):2526–2534. doi: 10.3168/jds.S0022-0302(88)79841-0. [DOI] [PubMed] [Google Scholar]
  13. Lewin H. A., Wu M. C., Stewart J. A., Nolan T. J. Association between BoLA and subclinical bovine leukemia virus infection in a herd of Holstein-Friesian cows. Immunogenetics. 1988;27(5):338–344. doi: 10.1007/BF00395129. [DOI] [PubMed] [Google Scholar]
  14. Mammerickx M., Lorenz R. J., Straub O. C., Donnelly W. J., Flensburg J. C., Gentile G., Markson L. M., Ressang A. A., Taylor S. M. Bovine hematology. III. Comparative breed studies on the leukocyte parameters of several European cattle breeds as determined in the common reference laboratory. Zentralbl Veterinarmed B. 1978 May;25(4):257–267. [PubMed] [Google Scholar]
  15. Miller J. M., Van der Maaten M. J. A complement-fixation test for the bovine leukemia (C-type) virus. J Natl Cancer Inst. 1974 Dec;53(6):1699–1702. [PubMed] [Google Scholar]
  16. Redfield R. R., Markham P. D., Salahuddin S. Z., Wright D. C., Sarngadharan M. G., Gallo R. C. Heterosexually acquired HTLV-III/LAV disease (AIDS-related complex and AIDS). Epidemiologic evidence for female-to-male transmission. JAMA. 1985 Oct 18;254(15):2094–2096. [PubMed] [Google Scholar]
  17. Sagata N., Yasunaga T., Tsuzuku-Kawamura J., Ohishi K., Ogawa Y., Ikawa Y. Complete nucleotide sequence of the genome of bovine leukemia virus: its evolutionary relationship to other retroviruses. Proc Natl Acad Sci U S A. 1985 Feb;82(3):677–681. doi: 10.1073/pnas.82.3.677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Stephens D. B. Stress and its measurement in domestic animals: a review of behavioral and physiological studies under field and laboratory situations. Adv Vet Sci Comp Med. 1980;24:179–210. [PubMed] [Google Scholar]

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