Abstract
Background
Health care utilization and costs among US veterans with chronic obstructive pulmonary disease (COPD) were compared with those in veterans without COPD.
Methods
A cohort of veterans with COPD was matched for age, sex, race, and index fiscal year to a cohort of veterans without COPD (controls) using data from the Veterans Integrated Service Network (VISN) 16 from 10/1/1997 to 9/30/2004. Annual total and respiratory-related health care service utilization, costs of care, comorbidities, and respiratory medication use at the time of diagnosis were assessed.
Results
A total of 59,906 patients with COPD were identified for a 7-year period prevalence of 8.2%, or 82 per 1000 population. Patients with COPD compared with controls had significantly higher all-cause and respiratory-related inpatient and outpatient health care utilization for every parameter examined including mean numbers of physician encounters, other outpatient encounters, emergency room visits, acute inpatient discharges, total bed days of care, and percentage of patients with any emergency room visits or any acute inpatient discharge. Patients with COPD had statistically significantly higher mean outpatient, inpatient, pharmacy, and total costs than the control group. The mean Charlson comorbidity index in patients with COPD was 1 point higher than in controls (2.85 versus 1.84, P < 0.001). 60% of COPD patients were prescribed medications recommended in treatment guidelines at diagnosis.
Conclusion
Veterans with COPD compared with those without COPD suffer a tremendous disease burden manifested by higher rates of all-cause and respiratory-related health care utilization and costs and a high prevalence of comorbidities. Furthermore, COPD patients do not receive appropriate treatment for their disease on diagnosis.
Keywords: chronic obstructive pulmonary disease (COPD), veterans, health care utilization, costs, respiratory medicine, VA, economic burden, burden of illness
Chronic obstructive pulmonary disease (COPD) may be a particularly significant health concern among military veterans. COPD is common in veterans and was a primary cause of mortality, second only to cancer and vascular disease, in a cohort of retired military Chinese veterans followed over an 18-year period.1 The high prevalence of COPD among veterans might be attributed to the strong association between combat experience and health risk behaviors including smoking,2 which is the major cause of COPD. The Department of Veterans Affairs (VA) – one of the largest managed care organizations in the United States – is integrally involved in the care of veterans with COPD. Each year, the VA provides care for approximately 500,000 patients with a diagnosis of COPD,3 and COPD is among the most common discharge diagnoses from VA hospitals.4
The VA health care system differs from other sectors of health care in the USA and resembles some of the international health care systems. Firstly, there are established enrollment eligibility criteria for use of the system. Secondly, the system does not provide incentives to the practitioners for under- or over utilization of health care resources. Thirdly, various specialists within the system review the literature and provide evidence-based guidelines for delivery of health care. Fourthly, due to its size, the VA health care system allows for negotiation of prices for various health care items at a significantly discounted level that can results in more cost effective delivery of health care systems. Finally, VA facilities uniquely represent a wide range of practice settings including academic and nonacademic hospitals and community-based health care facilities and thus diagnostic and treatment decisions are made by a variety of health care providers including pulmonologists, primary care providers, and allied health practitioners. The study of the burden of COPD in this system may provide information that can validly be applied to wide range of health delivery systems internationally.
The importance of the VA system to COPD care notwithstanding, little is known about health care utilization and health care costs in VA patients with COPD. The research that has been conducted suggests that VA patients with COPD frequently have other serious comorbid diseases, are significant users of health care resources, and are not being managed according to treatment guidelines.3–7 The study described herein, which involved a large sample of VA patients in the southwestern United States, was conducted to examine health care utilization and costs to the VA for patients with COPD compared with veterans without COPD. To the authors’ knowledge this study is the first large-scale assessment specifically aimed at assessing health care use and costs associated with COPD in the VA patient population.
Method
The protocol for this segmented, historical, retrospective, matched-cohort study was approved by the Baylor College of Medicine Institutional Review Board and the Michael E. DeBakey VA Medical Center Research and Development Review Committee. This study included data collected between 1 October 1997 and 30 September 2004.
Data source
Data were obtained from the VA Veterans Integrated Service Network (VISN) 16 Database Warehouse, a repository of administrative and clinical data from 10 Departments of VA medical centers in the south central United States. The VISN 16 Database Warehouse contains more than 759 million electronic medical records on more than 1.8 million patients. During the current study, 729,347 patients were treated for all conditions in the inpatient and outpatient facilities of VISN 16.
The VISN 16 Database Warehouse includes hospital discharge abstracts, data on outpatient clinic visits, pharmacy prescription fill records, and costs of care. The inpatient, outpatient, pharmacy, and cost data are computerized for each patient at local VA medical centers and are aggregated at the VISN level into the Database Warehouse.
Sample
Patients were eligible for the COPD group if they had a primary or secondary diagnosis of COPD based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes of 491.xx (chronic bronchitis), 492.xx (emphysema), 494.xx (bronchiecstasis), 495.xx (allergic alveolitis), or 496.xx (chronic airway obstruction). The ICD-9-CM codes of 494.xx and 495.xx were allowed only if there were other COPD codes in other diagnosis fields. It is notable that very few COPD patients had only 494.xx or only 495.xx as stand-alone diagnoses. These two conditions, which generally are not used to define COPD, are relatively rare in patients with COPD and do not respond well to COPD medications including bronchodilators and inhaled steroids. Patients with bronchiectasis usually present with frequent infections and airflow obstruction and are treated similarly to patients with COPD. Patients with allergic alveolitis usually present with symptoms similar to those of COPD. More importantly, COPD patients with asthma diagnoses were excluded. The index date was defined as the first date of COPD diagnosis. Patients with ICD-9-CM codes for other respiratory conditions including asthma, interstitial fibrosis, sarcoidosis, pulmonary hypertension, and pulmonary embolism, along with patients diagnosed with cancer other than skin nonmelanoma cancer were excluded.
For each COPD case, two patients without COPD were randomly selected to form the control group, which was matched to patients with COPD with respect to age, race/ ethnicity, sex, year in which the index diagnosis was made, and whether the index diagnosis was made in the inpatient or outpatient setting. Patients with any chronic respiratory condition were excluded from the control group.
Measures and data analyses
Measures included annual total and disease-specific related health care service utilization, costs of care, total illness burden, and use of respiratory medications at the time of COPD diagnosis.
Outpatient utilization included the numbers of physician encounters (nonlaboratory visits), nonphysician outpatient encounters, and emergency room visits. Inpatient utilization included acute inpatient discharges and total bed days of care for inpatient stays. These measures were stratified according to whether or not they were related to respiratory causes. Cost of care was examined for each category of outpatient and inpatient health care utilization. Pharmacy costs were summed for all pharmacy services. Respiratory-related health care utilization and costs were examined for the time period from 366 to 730 days following the patient’s index date, defined as the first date at which COPD was listed as a first or second diagnosis in either the inpatient or outpatient setting for patients with COPD and as the date of the encounter at which the patient was matched with a corresponding COPD patient for controls. Costs were examined beginning 366 days after index. Patients with an index date before 10/1/1998 were not included in these analyses because cost data were only available from 10/1/1999. Health care resource use was defined as respiratory-related if it involved the same ICD-9-CM codes used to define the population of COPD. This methodology is commonly accepted in retrospective observational studies whereby costs associated with a medical claim in the administrative database are attributed to the primary/secondary diagnosis on that claim.
Total illness burden for each patient was determined by constructing the Deyo-adapted version of the Charlson Comorbidity Index.8 For each patient, all inpatient discharges and all outpatient visit records were searched for one year prior to index date to determine the presence of 17 comorbid conditions, identified using corresponding ICD-9-CM diagnosis codes, comprising the Charlson Comorbidity Index components.8 The comorbidity index was constructed for each patient using the sum of the weighted values. Indicator variables for the following 13 comorbid conditions of interest were similarly created: depression; angina; cardiac dysrhythmias; pulmonary embolism; pneumonia; acute upper respiratory infection; otitis media; disorders of lipid metabolism; hypertension; osteoporosis; gastroesophageal reflux disease; septicemia; alcohol/drug abuse, dependence, or poisoning.
Respiratory medication use in the following therapeutic categories was examined for the patients with COPD: inhaled corticosteroids; long- or short-acting beta-agonists; long- or short-acting anticholinergics; and inhaled corticosteroids/ long-acting beta-agonists combination agonists. All prescriptions filled within 90 days prior to or after the index date were searched for use of these classes of medications.
Bivariate comparisons between patients with COPD and control patients were made for all demographic measures, measures of utilization and costs, the Charlson Comorbidity Index and individual Charlson comorbidities, and the 13 additional comorbidities using t-tests and Chi-square tests as appropriate.
Results
Baseline demographics
A total of 59,906 patients with COPD were identified for a 7-year period prevalence of 8.2% and were matched to 117,546 patients without COPD (Table 1). Mean age, gender, sex, and race/ethnicity distributions were comparable between patients with COPD and controls.
Table 1.
Baseline demographics
| COPD patients (N = 59,906) | Control patients (N = 117,546) | P value | |
|---|---|---|---|
| Mean age, years (SD) | 65.63 (11.24) | 65.52 (11.77) | 0.074 |
| Age group, n (%) | |||
| <40 years | 833 (1.39) | 2025 (1.72) | <0.0001 |
| 40 to 54 years | 9968 (16.64) | 19,538 (16.62) | |
| 55 to 64 years | 14,821 (24.74) | 29,432 (25.04) | |
| 65 to 74 years | 19,778 (33.02) | 36,538 (31.08) | |
| 75+ years | 14,506 (24.21) | 30,013 (25.53) | |
| Male, n (%) | 58,579 (97.78) | 114,904 (97.75) | 0.6616 |
| Race, n (%) | |||
| White | 42,346 (70.69) | 82,486 (70.17) | 0.2801 |
| Black | 8366 (13.97) | 16,687 (14.20) | |
| Hispanic | 362 (0.60) | 717 (0.61) | |
| Other | 270 (0.45) | 535 (0.46) | |
| Missing/Unknown | 8562 (14.29) | 17,121 (14.57) | |
Abbreviations: COPD, chronic obstructive pulmonary disease; SD, standard deviation.
Health care utilization and costs
Patients with COPD compared with controls had statistically significantly greater inpatient and outpatient health care utilization for every parameter examined including mean numbers of physician encounters (nonlaboratory visits), other outpatient encounters, emergency room visits, acute inpatient discharges, total bed days of care, and percentages of patients with any emergency room visit or any acute inpatient discharge compared with controls (Table 2). These differences applied both to respiratory-related health care use and health care use related to all other causes.
Table 2.
Second-year utilization and cost outcomes1
| Respiratory-related | All other | Overall | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| COPD | Control | P value | COPD | Control | P value | COPD | Control | P value | ||
| Health care resource use | ||||||||||
| # of physician encounters (non-lab visits)2 | Mean | 0.75 | 0.075 | <0.0001 | 4.58 | 3.37 | <0.0001 | 5.33 | 3.44 | <0.0001 |
| # of other outpatient encounters2 | Mean | 0.17 | 0.01 | <0.0001 | 6.20 | 3.89 | <0.0001 | 6.37 | 3.90 | <0.0001 |
| # of emergency room visits2 | Mean | 0.13 | 0.023 | <0.0001 | 0.48 | 0.250 | <0.0001 | 0.61 | 0.274 | <0.0001 |
| Any emergency room visit3 | n | 3,666 | 1,666 | <0.0001 | 9,323 | 11,600 | <0.0001 | 10,804 | 12,277 | <0.0001 |
| % | 8.56 | 1.94 | na | 21.80 | 13.56 | na | 25.25 | 14.35 | na | |
| # of acute inpatient discharges4 | Mean | 0.072 | 0.0059 | <0.0001 | 0.134 | 0.072 | <0.0001 | 0.206 | 0.078 | <0.0001 |
| Total bed days of care5 | Mean | 4.97 | 1.17 | <0.0001 | 8.90 | 12.07 | <0.0001 | 13.87 | 13.24 | <0.0001 |
| Any acute inpatient discharge5 | n | 2,356 | 452 | <0.0001 | 3,651 | 4,199 | <0.0001 | 5,227 | 4,455 | <0.0001 |
| % | 5.50 | 0.53 | na | 8.53 | 4.91 | na | 12.21 | 5.20 | na | |
| Length of stay5 | Mean | 3.84 | 1.07 | <0.0001 | 5.70 | 8.31 | <0.0001 | 9.54 | 9.38 | <0.0001 |
| Costs | ||||||||||
| Outpatient $ | Mean | 191.72 | 21.30 | <0.0001 | 1,616.90 | 1,071.31 | <0.0001 | 1,808.62 | 1,092.60 | <0.0001 |
| Inpatient $ | Mean | 484.97 | 47.21 | <0.0001 | 2,144.09 | 1,126.89 | <0.0001 | 2,629.06 | 1,174.10 | <0.0001 |
| Pharmacy $ | Mean | na | na | na | na | na | na | 1,256.10 | 747.10 | <0.0001 |
| Total $ | Mean | 676.68 | 68.50 | <0.0001 | 3,761.00 | 2,198.20 | <0.0001 | 5,693.78 | 3,013.80 | <0.0001 |
Notes:
This table shows utilization and costs for the time period from 366 to 730 days following the patient’s index date. For patients with COPD, the index date is the first date at which COPD was listed as a first or second diagnosis in either the inpatient or outpatient setting. For controls, the index date is the date of the encounter at which the patient was matched with a corresponding COPD patient. Patients with an index date before 10/1/1998 were not included in this table because cost data were only available starting on 10/1/1999.
Number and percentage of patients with one or more visits to a VA outpatient clinic.
Mean number of days on which a patient visited one or more VA outpatient clinics.
Mean number of discharges among all patients in the cohort, including those with no hospital stays.
Total bed days of care, mean length of stay, and number and percentage of patients are among patients who had one or more hospital stays at a VA acute care facility.
Abbreviations: COPD, chronic obstructive pulmonary disease; NA, not available; VA, veterans Affairs.
Furthermore, patients with COPD had significantly higher mean outpatient, inpatient, pharmacy, and total costs for both respiratory health care utilization and health care utilization related to all other causes compared with controls (Table 2). Mean respiratory-related total health care costs (the sum of the outpatient, inpatient, and pharmacy costs) were approximately 10 times higher in patients with COPD than controls ($676.68 versus $68.50 per patient for the second year of utilization, P < 0.0001).
Comorbidities
Patients with COPD had a significantly higher comorbid illness burden than controls (Table 3). The mean Charlson Comorbidity Index in patients with COPD was one point higher (indicating at least one comorbidity more, on average) than in controls (2.85 versus 1.84; P < 0.0001).
Table 3.
Charlson Comorbidity Index and Charlson Comorbidity Index components
| COPD patients (N = 59,906) | Control patients (N = 117,546) | P value | |
|---|---|---|---|
| Charlson Comorbidity Index, mean (SD) | |||
| 2.85 (1.46) | 1.84 (1.52) | <0.0001 | |
| Charlson comorbidity index components, n (%) | |||
| Myocardial infarction | 1828 (3.05) | 3103 (2.64) | <0.0001 |
| Congestive heart failure | 6270 (10.47) | 5937 (5.05) | <0.0001 |
| Peripheral vascular disease | 3238 (5.41) | 4238 (3.61) | <0.0001 |
| Cerebrovascular disease | 3848 (6.42) | 7701 (6.55) | 0.3010 |
| Dementia | 681 (1.14) | 1965 (1.67) | <0.0001 |
| Chronic pulmonary disease | 59,906 (100) | 0 (0) | na |
| Rheumatologic disease | 992 (1.66) | 1473 (1.25) | <0.0001 |
| Peptic ulcer disease | 2083 (3.48) | 2586 (2.20) | <0.0001 |
| Mild liver disease | 518 (0.86) | 981 (0.83) | 0.5121 |
| Diabetes – mild to moderate | 8182 (13.66) | 21,613 (18.39) | <0.0001 |
| Diabetes with chronic complications | 2257 (3.77) | 5573 (4.74) | <0.0001 |
| Paraplegia or hemiplegia | 418 (0.70) | 1074 (0.91) | <0.0001 |
| Renal disease | 1425 (2.38) | 2672 (2.27) | 0.1614 |
| Any malignancy/lymphoma/leukemia | 6367 (10.63) | 11,561 (9.84) | <0.0001 |
| Moderate or severe liver disease | 143 (0.24) | 386 (0.33) | 0.0011 |
| Metastatic solid tumor | 0 (0) | 0 (0) | na |
| Acquired immune deficiency syndrome (AIDS) | 510 (0.85) | 1473 (1.25) | <0.0001 |
Abbreviations: COPD, chronic obstructive pulmonary disease; SD, standard deviation.
Myocardial infarction, congestive heart failure, peripheral vascular disease, rheumatologic disease, peptic ulcer disease, and malignancy/lymphoma/leukemia were significantly more frequent in patients with COPD than in controls (Table 3).
Table 4 shows other baseline comorbid conditions for COPD group versus the control group.
Table 4.
Baseline other comorbidities, n (%)
| COPD patients (N = 59,906) | Control patients (N = 117,546) | P value | |
|---|---|---|---|
| Depression | 6279 (10.48) | 10,014 (8.52) | <0.0001 |
| Angina | 3006 (5.02) | 3605 (3.07) | <0.0001 |
| Cardiac dysrhythmias | 5414 (9.04) | 8506 (7.24) | <0.0001 |
| Pulmonary embolism | 173 (0.29) | 165 (0.14) | <0.0001 |
| Pneumonia | 3226 (5.39) | 1870 (1.59) | <0.0001 |
| Acute upper respiratory infections | 6489 (10,83) | 5707 (4.86) | <0.0001 |
| Otitis media | 656 (1.10) | 1053 (0.90) | <0.0001 |
| Disorders of lipid metabolism | 613 (1.02) | 1087 (0.92) | 0.0439 |
| Hypertension | 28,233 (47.13) | 54,126 (46.05) | <0.0001 |
| Osteoporosis | 723 (1.21) | 677 (0.58) | <0.0001 |
| Gastroesophageal reflux disease | 587 (0.98) | 686 (0.58) | <0.0001 |
| Septicemia | 291 (0.49) | 689 (0.59) | 0.0070 |
| Alcohol/drug abuse, dependence, or poisoning | 12,519 (20.90) | 12,539 (10.67) | <0.0001 |
Abbreviation: COPD, chronic obstructive pulmonary disease.
Medications
Approximately three fifths (60.6%) of patients with COPD were receiving some type of respiratory medication (Table 5). The most common respiratory treatment was short-acting beta-agonists, which were prescribed to 54.5% of patients with COPD at baseline. Less than 1% of patients with COPD were receiving an inhaled corticosteroid/long-acting beta-agonist combination at the time of diagnosis.
Table 5.
Baseline respiratory pharmacotherapies among patients with COPD
| n | % of total 59,906 | % of treated 36,285 | |
|---|---|---|---|
| Treated1 | 36,285 | 60.6 | 100.0 |
| Inhaled corticosteroid+long-acting | 449 | 0.7 | 1.2 |
| beta-agonist combination, any Inhaled corticosteroid+long-acting | 261 | 0.4 | 0.7 |
| beta-agonist combination 250/50 Inhaled corticosteroid | 11,177 | 18.6 | 30.8 |
| Short-acting beta-agonist | 32,629 | 54.5 | 89.9 |
| Long-acting beta-agonist | 2,176 | 3.6 | 6.0 |
| Short- or long-acting anticholinergic | 13,493 | 22.5 | 37.2 |
| Untreated2 | 23,621 | 39.4 | na |
Notes:
Defined as receiving medications in these drug class groups within 90 days before or after the index date.
Not treated with any of these groups.
Abbreviation: COPD, chronic obstructive pulmonary disease.
Discussion
In this study we have demonstrated the huge impact of COPD on the US VA population. Almost 1 in 10 patients in the southeastern US seen in the VA health care system had COPD. This prevalence is higher than the 42 per 1000 estimated by the National Center for Vital Statistics9 but generally comparable to estimates from the National Heart Lung and Blood Institute.10 The 8.2% prevalence rate in the current study is consistent with previous observations suggesting that veterans have a higher burden of illness than nonveterans.11 Patients with COPD compared with age-, race-, sex-, and index year-matched patients without COPD in this study had higher rates of inpatient and outpatient utilization and higher costs of care for respiratory conditions and all other conditions. In patients with COPD compared with controls, mean total respiratory-related total health care costs (the sum of the outpatient, inpatient, and pharmacy costs) were approximately 10 times higher, and total costs for all other conditions were approximately 1.7 times higher. The results suggest that the high prevalence of COPD and the excess health care resource use in the VA population place a substantial burden on the federal government to provide care for these patients.
It is difficult to compare the costs of care in this VA with those described in other studies due to differences in study designs, populations studied, and methodology used, as well as disparate health care systems in place. However, the VA system, when stacked against systems used in European countries, doesn’t seem as farfetched a comparison upon closer comparison. There are established eligibility criteria for enrollment, no resource-based incentives are offered, decisions are formulated on the basis of evidence provision, and there is a strong negotiating power due to its size, as well as the fact that the government is involved. In fact, this system may be similar to national insurance health care systems seen in many European countries. This study therefore can add to the body of literature aimed at studying COPD as a disease and costs from the perspective of a government-based health care system. Studies of the costs of COPD in other countries corroborate results of the current study by demonstrating the substantial economic impact of COPD, particularly in patients with severe disease and/or frequent exacerbations. 12–15 Costs reported in this study are not expenditures by the patient, but are derived from the VA perspective, which allocates costs to services from a global budget for a given year. Costs in the VA system vary based on the number of services provided (more services and lower budget mean lower average costs). In 2000, the mean annual Medicare expenditures in the US were $11,841 for patients with COPD compared with $4901 for all covered patients.16 In a study of 6,793 Texas Medicaid patients with COPD, the annual costs of care totaled $11,580 per patient.17 In the current study, total costs during the second year of utilization of services for patients with COPD were $4,437 per patient. This value is comparable to the mean costs of care in a study of VA patients with chronic conditions. 18 The costs of care in the current study are therefore consistent with those described in previous VA populations but substantially lower than those in patient populations from other health care systems in the United States.
The high frequency of comorbid conditions adds to the disease and cost burden in the VA population. This finding corroborates other research conducted in non-US patients not selected with respect to veteran status.19 In the current study, patients with COPD compared with controls were significantly more likely to have comorbidities including chronic debilitating or life-threatening diseases. The high frequency of comorbidities in veterans with COPD has been described in other studies.5,6 In a study of 70,679 patients with COPD hospitalized at a VA hospital in 1998, the prevalence of cardiovascular comorbidities substantially exceeded that in an age- and gender-matched cohort without COPD at 33.6% versus 27.1% for coronary artery disease, 24.4% versus 13.5% for congestive heart failure, and 14.3% versus 10.4% for atrial fibrillation.5 Comorbidities can also increase the risk of poor outcomes following an exacerbation of COPD. A study of 51,353 patients discharged after an exacerbation of COPD in the VA system identified pulmonary hypertension and weight loss as risk factors for death.6
In a recent study of 6,793 Texas Medicaid patients with COPD,17 the mean Charlson Comorbidity Index was approximately 1.9, a value similar to that seen in the control cohort but approximately one point lower than that seen in the COPD cohort in the current study. Furthermore, 7% of COPD patients in that study were hospitalized for any cause versus 14.0% in the current study, although 83% of the Medicaid patients had emergency department visits versus 30.4% in the current study. Patients in the current study were more likely to be seen in the inpatient setting, an observation that suggests greater severity of illness among patients with COPD in this study than in the Texas Medicaid study.
Perhaps the most striking finding in the current study is the seeming undertreatment of the COPD population. Approximately 40% of patients were not receiving any of the medications recommended in global treatment guidelines20 at baseline. The most common respiratory medication prescribed for these patients with COPD was short-acting beta-agonists, which according to treatment guidelines are to be used as rescue medications and not as maintenance treatment. Maintenance treatment with guidelines-recommended long-acting bronchodilators was prescribed in the minority of patients in the current study. These findings are consistent with results of studies from Canada, Japan, and Europe, in which patients were not selected based on veteran status.21–24
Strengths of the current study include the large sample size and the examination of patients in a federally funded and operated integrated managed care system. As VA physicians are salaried and as Congress determines the total VA health care budget, few negative incentives operate either to limit care for VA patients or to exaggerate the illness burden in order to garner more resources. The results of the current study therefore are likely to reflect actual illness burden and health care use for these patients. The matched case-control design, which contributes to good internal validity, lends strength to the rigor of this study. The matched design allowed the utilization and cost measures to be adjusted for demographic, temporal, and contextual variables to reduce confounding.
Codes for bronchiectasis and allergic alveolitis were included in the ICD-9-CM-based definition of COPD in this study. Patients with bronchiectasis usually present with frequent infections and airflow obstruction and are treated similarly to patients with COPD. Patients with allergic alveolitis usually present with symptoms similar to those of COPD. Because these cases were so few in number (0.15%), they are unlikely to have affected the results. Notably, multiple diagnosis fields are included on medical claims in VA administrative data. In the very few cases of bronchiectasis and allergic alveolitis that were observed, COPD was also present on these medical claims. The clinical reasons explained above did not permit a clear rationale for excluding these cases.
This study has certain limitations inherent to retrospective observational studies involving claims data. Accuracy and completeness of diagnosis codes cannot be verified. However, the VA has relatively complete utilization records and is less susceptible to problems of coding bias that may occur in other managed care systems. The reliance of this study on VA pharmacy prescription fill records for estimates of medication use is a limitation that could have led to underestimation of medication use. The records do not contain information on out-of-plan (non-VA) prescriptions, such as Medicaid or Medicare or private insurance, for which the veteran may be eligible, nor do they capture over-the-counter pharmacy use. While the extent of out-of-plan or out-of-network pharmacy use cannot be determined, it is thought to have been relatively infrequent. Also, the pharmacy prescription records for this study were obtained only from VISN 16 data warehouse records and did not include VA prescription fills outside of VISN 16. The data were obtained from a primarily male VA population and cannot be generalized to women or nonveterans. Although comorbidities play a role in overall cost burden to the VA system, comorbid conditions can also increase COPD complexity pathologically and in economic terms. For example, having cardiovascular disease may make COPD exacerbations more common; therefore, having that comorbidity will increase the costs involved with treating COPD as well. Therefore, it may not be entirely accurate to say that all those costs are part of a global chronic burden for patients. Admittedly, lack of functional data prevents conclusive exploration of this issue. Another limitation may be lack of adjustment for presence of comorbidities. In the absence of objective lung function data (absent in administrative claims databases such as the VA), one cannot say with complete certainty whether rates of maintenance treatment were indeed lower. This is a limitation found in administrative claims databases like the VA system. Finally, the study was conducted in the United States, and the generalizability of the results to other countries is not known. However, as discussed earlier, the VA system design is similar to countries in Europe that have national health care models. Therefore, there is possibility that the results from this study are applicable to those countries. Within the United States, however, the VA system is very different from closed network health maintenance organizations (HMOs), commercial health plans, and federally funded Medicare and Medicaid programs.
In conclusion, veterans with COPD compared with those without COPD suffer a tremendous disease burden with high rates of all-cause and respiratory-related health care utilization and higher health care costs. Furthermore, a significant number of these patients remain untreated, a finding corroborating data from other studies.21,22,25 The results underscore the undertreatment of COPD in the current health care system. Future researchers should examine treatment strategies and interventions that may help reduce the burden of COPD in the veterans population.
Acknowledgments
This study (ADC104595) was funded by GlaxoSmithKline. This work was supported in part by the Houston VA HSR&D Center of Excellence (HFP90-020). The authors thank Jane Saiers, PhD, for editorial assistance with the manuscript. Saiers edited the manuscript after it had been written by the authors. Her work was funded by GlaxoSmithKline.
Footnotes
Conflicts of interests
Anand A Dalal is employed by GlaxoSmithKline. Amir Sharafkhaneh is a speaker for GlaxoSmithKline, Boehringer Ingelheim, Pf izer, and Dey and has participated in advisory boards for GlaxoSmithKline, Pfizer, and Dey Pharmaceuticals. Nancy Petersen and Hong Yu report no conflicts of interest. Nicola Hanania has received research grant support and served as a consultant or speaker for GlaxoSmithKline, Dey, Sepracor, Novartis, and Boehringer Ingelheim. Michael Johnson has received research grant support from GlaxoSmithKline in connection with this study.
References
- 1.Sai XY, He Y, Men K, et al. All-cause mortality and risk factors in a cohort of retired military male veterans, Xi’an, China: an 18-year follow up study. BMC Public Health. 2007;7:290. doi: 10.1186/1471-2458-7-290. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Stellman S, Stellman J, Koenen K. Enduring social and behavioral effects of exposure to military combat in Vietnam. Ann Epidemiol. 2000;10:480. doi: 10.1016/s1047-2797(00)00161-7. [DOI] [PubMed] [Google Scholar]
- 3.Joo MJ, Lee TA, Bartle B, van de Graff WB, Weiss KB. Patterns of healthcare utilization by COPD severity: a pilot study. Lung. 2008;185:307–312. doi: 10.1007/s00408-008-9095-5. [DOI] [PubMed] [Google Scholar]
- 4.Pirraglia PA, Charbonneau A, Kader B, et al. Adequate initial antidepressant treatment among patients with chronic obstructive pulmonary disease in a cohort of depressed veterans. Prim Care Companion J Clin Psychiatry. 2006;8:71–76. doi: 10.4088/pcc.v08n0203. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Mapel DW, Dedrick D, Davis K. Trends and cardiovascular comorbidities of COPD patients in the Veterans Administration Medical System, 1991–1999. COPD. 2004;2:35–41. doi: 10.1081/copd-200050671. [DOI] [PubMed] [Google Scholar]
- 6.McGhan R, Radcliff T, Fish R, et al. Predictors of rehospitalization and death after a severe exacerbation of COPD. Chest. 2007;132:1748–1755. doi: 10.1378/chest.06-3018. [DOI] [PubMed] [Google Scholar]
- 7.Lee TA, Shields AE, Vogeli C, et al. Mortality rate in veterans with multiple chronic conditions. J Gen Intern Med. 2007;22(Suppl 3):403–407. doi: 10.1007/s11606-007-0277-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45:613–619. doi: 10.1016/0895-4356(92)90133-8. [DOI] [PubMed] [Google Scholar]
- 9.Hoyert DL, Heron MP, Murphy SL, Kung HC. Deaths: final data for 2003. Natl Vit Stat Rep. 2003;54:1–120. [PubMed] [Google Scholar]
- 10.National Heart, Lung, and Blood Institute. Morbidity and Mortality: Chartbook on Cardiovascular, Lung and Blood Diseases. Bethesda, MD: US Department of Health and Human Service, National Institutes of Health; 2004. [Google Scholar]
- 11.Rogers WH, Kazis LE, Miller DR, et al. Comparing the health status of VA and non-VA ambulatory patients: the veterans’ health and medical outcomes studies. J Ambul Care Manage. 2004;27:249–262. doi: 10.1097/00004479-200407000-00009. [DOI] [PubMed] [Google Scholar]
- 12.Chiang CH. Cost analysis of chronic obstructive pulmonary disease in a tertiary care setting in Taiwan. Respirology. 2008;13:689–694. doi: 10.1111/j.1440-1843.2008.01308.x. [DOI] [PubMed] [Google Scholar]
- 13.Jahnz-Rozyk K, Targowski T, From S. Costs of exacerbations of chronic obstructive pulmonary disease in primary and secondary care in 2007 – results of multicenter Polish study. Pol Merkue Lekarski. 2009;26:208–214. [PubMed] [Google Scholar]
- 14.Nielsen R, Johannessen A, Benediktsdottir B, et al. Present and future costs of COPD in Iceland and Norway: results from the BOLD study. Eur Respir J. 2009;34:850–857. doi: 10.1183/09031936.00166108. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 15.Miravitlies J, Brosa M, Velasco M, et al. An economic analysis of pharmacological treatment of COPD in Spain. Respir Med. 2009;103:714–721. doi: 10.1016/j.rmed.2008.11.019. [DOI] [PubMed] [Google Scholar]
- 16.Ruchlin HS, Dasbach EJ. An economic overview of chronic obstructive pulmonary disease. Pharmacoeconomics. 2001;19:623–642. doi: 10.2165/00019053-200119060-00002. [DOI] [PubMed] [Google Scholar]
- 17.Rascati KL, Akazawa M, Johnsrud M, et al. Comparison of hospitalizations, emergency department visits, and costs in a historical cohort of Texas Medicaid patients with chronic obstructive pulmonary disease, by initial medication regimen. Clin Ther. 2007;29:1203–1213. doi: 10.1016/j.clinthera.2007.06.006. [DOI] [PubMed] [Google Scholar]
- 18.Yu W, Ravelo A, Wagner TH, et al. The relationships among age, chronic conditions, and healthcare costs. Am J Manag Care. 2004;10:909–916. [PubMed] [Google Scholar]
- 19.Gerdtham UG, Andersson LF, Ericsson A, et al. Factors affecting chronic obstructive pulmonary diseas e(COPD)-related costs: a multivariate analysis of a Swedish COPD cohort. Eur J Health Econ. 2009;10:217–226. doi: 10.1007/s10198-008-0121-6. [DOI] [PubMed] [Google Scholar]
- 20.Global Initiative for Chronic Obstructive Lung Disease. Executive Summary. National Institutes of Health: National Heart, Lung, and Blood Institute; [Accessed from January 10, 2010]. Updated 2007. Available: http://www.goldcopd.com/Guidelineitem.asp?l1=2&l2=1&intId=996. [Google Scholar]
- 21.Bourbeau J, Sebaldt RJ, Day A, et al. Practice patterns in the management of chronic obstructive pulmonary disease in primary practice: the CAGE study. Can Respir J. 2008;15:13–19. doi: 10.1155/2008/173904. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 22.Takahashi T, Ichinose M, Inoue H, et al. Underdiagnosis and undertreatment of COPD in primary care settings. Respirology. 2003;8:504–508. doi: 10.1046/j.1440-1843.2003.00501.x. [DOI] [PubMed] [Google Scholar]
- 23.Del Negro R, Rossi A, Cerveri I. The burden of COPD in Italy: results from the Confronting COPD survey. Respir Med. 2003;97(Suppl C):S43–S50. doi: 10.1016/s0954-6111(03)80024-0. [DOI] [PubMed] [Google Scholar]
- 24.Piperno D, Huchon G, Pribil C, et al. The burden of COPD in France: results from the Confronting COPD survey. Respir Med. 2003;97(Suppl C):S33–S42. doi: 10.1016/s0954-6111(03)80023-9. [DOI] [PubMed] [Google Scholar]
- 25.Miravitlles M, de la Roza C, Naberan K, et al. Use of spirometry and patterns of prescribing in COPD in primary care. Respir Med. 2008;101:1753–1760. doi: 10.1016/j.rmed.2007.02.019. [DOI] [PubMed] [Google Scholar]