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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Int J Stroke. 2010 Apr;5(2):74–79. doi: 10.1111/j.1747-4949.2010.00411.x

Production and validation of Putonghua- and Cantonese-Chinese language National Institutes of Health Stroke Scale Training and Certification Videos

R T F Cheung 1,2,3,*, P D Lyden 4,5, T H Tsoi 6, Y Huang 7, M Liu 8, S F K Hon 3, R Raman 4,9, L Liu 9
PMCID: PMC2867085  NIHMSID: NIHMS178407  PMID: 20446940

Abstract

Background and purposes

The National Institutes of Health Stroke Scale (NIHSS) is an integral part of acute stroke assessment. We report our experience with new Putonghua- and Cantonese-Chinese language NIHSS (PC-NIHSS and CC-NIHSS) training and certification videos.

Methods

A professional video production company was hired to create the training and certification videos for both PC-NIHSS and CC-NIHSS. Two training and certification workshops were held in Chengdu and Beijing, and two workshops in Hong Kong. The instruction, training and group A certification videos were presented to workshop attendees. Un-weighted κ statistics were used to measure the agreement among raters, and the inter-rater agreements for PC-NIHSS and CC-NIHSS videos were compared with those of original English language NIHSS (E-NIHSS) videos.

Results

The pass rates using PC-NIHSS and CC-NIHSS videos were 79% and 82%, respectively. All possible responses on individual scale items were included. Facial palsy and limb ataxia (13%) showed poor agreement, nine (60%) to 10 (67%) items showed moderate agreement (0.4<κ<0.75), and three (20%) to four (27%) items showed excellent agreement. When compared with E-NIHSS videos, the agreements on best gaze, visual fields, facial weakness and aphasia were less for PC-NIHSS videos, and the agreements on commands for level of consciousness and visual fields were less for CC-NIHSS videos. Nevertheless, there was no difference between PC-NIHSS or CC-NIHSS and E-NIHSS videos in the agreement total score.

Conclusions

Compared with E-NIHSS videos, PC-NIHSS and CC-NIHSS videos show good content validity and inter-rater reliability. Availability of these videos may facilitate the proper use of NIHSS among physicians and nurses in Potunghua- or Cantonese-speaking communities.

Keywords: Cantonese, Chinese, Mandarin, Putonghua, reliability, stroke assessment, stroke outcome measures, stroke scales

Introduction

Multicentre clinical trials on novel stroke therapies require a reliable, valid and time-efficient rating scale to measure stroke deficits (18). The NIHSS was developed for use in clinical trials, notably the landmark clinical stroke trials on recombinant tissue plasminogen activator (9). NIHSS contains 15 items, including level of consciousness, eye movement, visual field, facial movement, limb power, coordination, sensation, language, speech and neglect (3, 10). The scale items are scored according to severity using predefined, weighted scores. NIHSS has become an integral part of the acute stroke assessment in both research and clinical settings (1113).

A formal training and certification process, using validated videos in English, is required to ensure the proper application of NIHSS. Original videos were created in 1988 and made into videotapes for training and certification (3). New training and certification videos were created in 2003 and saved on DVD (10). In addition, real-time, online training and certification for NIHSS have been available since 2005 (http://nihss-english.traniningcampus.net). The target audiences for this accredited programme of NIHSS training and certification are stroke care providers and researchers. The instructions have been translated and dubbed from English into Italian and Portuguese, Spanish, German, French, Russian, Bulgarian, Czech, Dutch and Romanian have been completed or planned (http://www.nihstrokescale.org). Nevertheless, the set of tools in English for assessment of language and speech may not be appropriate for languages other than English, voice-over of the patients’ verbal responses is artificial, and interpretation of impairments in language and speech may be different between English and languages other than English.

China has one-fifth of the world’s population and approximately 1.05 billion Chinese speak Mandarin either as a first or second language (http://www.nvtc.gov/lotw/months/november/worldlanguages.htm). Mandarin is the official language of mainland China and Taiwan as well as an official language of Singapore. Mandarin is officially known as Putonghua in mainland China because the word ‘Putonghua’ means ‘common language’. Around 71 million people speak Cantonese as their first language in Guandong province, Guangzhou city (Canton), Hong Kong and Macau, as well as in expatriate Chinese communities globally (http://www.nvtc.gov/lotw/months/may/Cantonese.htm). To facilitate and encourage the proper use of NIHSS among physicians and nurses in communities speaking either Putonghua or Cantonese, we produced a new set of Putonghua-Chinese language NIHSS (PC-NIHSS) training and certification videos and a new set of Cantonese-Chinese language NIHSS (CC-NIHSS) training and certification videos, and compared with the original English language NIHSS (E-NIHSS) videos regarding the level of inter-rater reliability. Here we report our experience on NIHSS training and certification using new PC-NIHSS or CC-NIHSS videos.

Methods

A professional video production company was appointed in June 2006 to create new Chinese language versions of NIHSS training and certification videos in both Putonghua and Cantonese. First, original scripts of E-NIHSS training and certification videos on DVDs were translated from English into Putonghua- or Cantonese-Chinese (10). Second, language assessment (item 9) requires a patient to describe the cookie jar picture, name the objects from the object card, and read the sentences from the sentence card. To assess aphasia in a Putonghua-speaking patient, the object card was modified to include objects familiar to Chinese speakers, and avoid objects that would be unknown outside of Western countries, e.g. ‘cactus’ and ‘hammock’. Appropriate sentences in Chinese were included in the sentence card. Evaluation of articulation (item 10) requires an English-speaking patient to read words that include all phonemes used in English language (http://www.nihstrokescale.org). The word card was modified extensively to include phonemes commonly used by native Putonghua speakers, and exclude phonemes used only by English speakers. These cards were previously used in a multicentre stroke trial conducted in mainland China (14). Similar modifications were made to these cards to allow proper assessment of aphasia in a Cantonese-speaking patient; these cards were previously used in a multicentre stroke trial conducted in Hong Kong (15).

Third, filming of CC-NIHSS videos took place in the Neurology Wards at Queen Mary Hospital and Pamela Youde Eastern Hospital based in Hong Kong over 5 days from July 2006 to September 2006. Filming of PC-NIHSS videos took place in Neurology Wards of Peking University First Hospital, Beijing, China from 25–29 September 2006. Similar to the production of E-NIHSS videos on DVDs, stroke patients were selected so that every choice in every scale item would be illustrated at least once and that their stroke severity was similar to that of E-NIHSS videos. In general, two cameras captured the video from both the front and side with scrupulous attention to sound and lighting to optimise video illustration of the proper technique and findings (3, 10). Consent for videotaping was obtained from all patients.

NIHSS examinations were videotaped from a total of 30 native Putonghua-speaking patients and another 30 native Cantonese-speaking patients. For PC-NIHSS videos, 12 cases were used in the instruction and demonstration sections, and remaining 18 cases were chosen for certification purpose. Similar case selection was done for CC-NIHSS videos. Thus, both PC-NIHSS and CC-NIHSS videos contain three groups of certification cases with six patients per group, being balanced for severity and stroke (10).

Three bilingual stroke neurologists certified previously and experienced in E-NIHSS independently scored all items of the 18 certification cases of both PC-NIHSS and CC-NIHSS. Upon disagreement on the score of an item, the video segment was reviewed to generate the acceptable score/s of the item. For PC-NIHSS videos, a training and certification workshop was held in Chengdu, China, 27 August 2007 and another one was held in Beijing, China on 1 September 2007. In addition, two training and certification workshops were held in Hong Kong in June 2008 using CC-NIHSS videos. After a brief introduction, the training and group A certification videos were presented over two sessions on the same day of the workshop. Certification was granted to the raters according the standard scoring rules (3).

Numerical data were described in mean±SD and categorical variables were given as numbers with percentages in parentheses. Demographic and other information of raters who passed the certification were compared with those who failed using Student’s t-test or χ2-test. Multiple logistic regression analysis identified the independent predictors for a pass in the certification workshops using PC-NIHSS or CC-NIHSS videos. To allow for comparison to E-NIHSS videos, unweighted κ statistics for multiple examiners were used to study the inter-rater agreement on individual items (16) of PC-NIHSS or CC-NIHSS videos. Our interpretation of the magnitude of κ coefficient is as follows:

  • κ<0.40 defines poor agreement,

  • 0.40≤κ≤0.75 defines moderate agreement, and

  • κ>0.75 defines excellent agreement.

The 95% bootstrap confidence interval (CI) was also generated (17). The κ coefficient of each item of PC-NIHSS or CC-NIHSS videos was compared with that of E-NIHSS videos on DVDs (10). If κ coefficient for an item of E-NIHSS videos is included within the 95% CI of κ coefficient of the corresponding item of PC-NIHSS or CC-NIHSS videos, we would conclude that there is no statistically significant difference between the two κ coefficients. Intraclass correlation coefficient (ICC) was used to study the agreement on the total score (18). An ICC value close to 1.0 indicates excellent agreement. The 95% bootstrap CI was also generated (17). ICC of E-NIHSS videos was compared with that of PC-NIHSS or CC-NIHSS videos using Fisher’s transformation (19).

Results

Altogether 310 doctors and nurses from 34 acute hospitals attended the two workshops in mainland China, and 295 raters submitted their scores for group A cases of PC-NIHSS videos. Item scores of group A cases were available for analyses from 295 raters, including 188 physicians, 78 residents and 29 nurses. We received 26 543 responses from an expected maximum of 27 900 responses (15 items × 6 patients × 310 attendees), giving a response rate of 95%. Using group A cases of PC-NIHSS videos, the pass rate was 79%. Demographic and other important information of these 295 raters is summarised in Table 1. Univariate analyses showed that passing the certification using PC-NIHSS videos was associated with medical background and previous experience in E-NIHSS. Multiple logistic regression analysis revealed occupation as the independent predictor (P =0.008) with nurses having a lower pass rate (odds ratio 0.244, 95% CI 0.096–0.623).

Table 1.

Demographics and other information of raters of PC-NIHSS videos*

All raters Passed raters Failed raters

Characteristics N =295 N =233 N =62 P value
Age (years) 30.1±7.2 30.0±7.1 30.3±7.6 0.740
Age ≥30 years 119 (40.3) 95 (40.8) 24 (38.7) 0.884
Male gender 114 (38.6) 92 (39.5) 22 (35.5) 0.660
Occupation groups 0.001
 Physician 188 (63.7) 154 (66.1) 34 (54.8)
 Resident 78 (26.4) 64 (27.5) 14 (22.6)
 Nurse 29 (9.8) 15 (6.4) 14 (22.6)
Working experience (years) 6.6±7.7 6.4±7.6 7.3±8.0 0.377
Working experience in groups 0.736
 No experience 80 (27.1) 65 (27.9) 15 (24.2)
 1–5 years 94 (31.9) 75 (32.2) 19 (30.6)
 >5 years 121 (41.0) 93 (39.9) 28 (45.2)
Experience with stroke patient 0.601
 No experience 34 (11.5) 25 (10.7) 9 (14.5)
 1–5 years 152 (51.5) 123 (52.8) 29 (46.8)
 >5 years 109 (36.9) 85 (36.5) 24 (38.7)
Experience with NIHSS 128 (43.4) 109 (46.8) 19 (30.6) 0.030
Trained with E-NIHSS videos 24 (8.1) 21 (9.0) 3 (4.8) 0.433
*

Numerical variables are in mean±SD and categorical variables in number with percentages in parentheses. The numbers do not add to the total because of missing data. The percentages do not add to 100 because of rounding. Comparisons between raters who passed and those who failed are made using Student’s t-test or χ2-test.

E-NIHSS, English language NIHSS; N, number of raters; NIHSS, National Institutes of Health Stroke Scale; PC-NIHSS, Putonghua-Chinese NIHSS.

For the workshops conducted in Hong Kong using CC-NIHSS videos, 294 nurses and 26 physicians from 14 acute public hospitals (271; 85%), six convalescent/rehabilitation hospitals (33; 10%), and other institutions (16; 5%) attended. The item scores from 290 nurses and 24 physicians were available for analyses. The response rate was 98% (28 259 responses from an expected maximum of 28 800 responses. Using CC-NIHSS training and certification videos, the overall pass rate was 82% (Table 2). Univariate analyses showed that passing the certification using CC-NIHSS videos was associated with an age <30 years and a shorter duration of working experience. Nevertheless, multiple logistic regression analysis did not identify any independent predictor.

Table 2.

Demographics and other information of the raters of CC-NIHSS videos*

All raters Passed raters Failed raters
Characteristics N =314 N =257 N =57 P value
Age (years) 37.0±8.5 36.5±8.5 38.9±8.2 0.057
Age ≥30 years 243 (77.4) 193 (75.1) 50 (87.7) 0.039
Male gender 49 (15.6) 36 (14.0) 13 (22.8) 0.098
Occupation groups 0.723
 Physician 24 (7.6) 19 (7.4) 5 (8.8)
 Nurse 290 (92.4) 238 (92.6) 52 (91.2)
Working experience (years) 14.6±8.4 14.2±8.4 16.6±8.1 0.044
Working experience in groups 0.124
 1–5 years 49 (15.7) 44 (17.2) 5 (8.9)
 >5 years 263 (84.3) 212 (82.8) 51 (91.1)
Experience with stroke patient 0.599
 No experience 6 (1.9) 4 (1.6) 2 (3.6)
 1–5 years 111 (36.0) 91 (36.0) 20 (36.4)
 >5 years 191 (62.0) 158 (62.5) 33 (60.0)
Experience with NIHSS 110 (35.0) 92 (35.8) 18 (31.6) 0.546
Trained with E-NIHSS videos 34 (10.8) 31 (12.1) 3 (5.3) 0.133
*

Numerical variables are in mean±SD and categorical variables in number with percentages in parentheses. The numbers do not add to the total because of missing data. The percentages do not add to 100 because of rounding. Comparisons between raters who passed and those who failed are made using Student’s t-test or χ2-test.

E-NIHSS, English language NIHSS; N, number of raters; NIHSS, National Institutes of Health Stroke Scale; CC-NIHSS, Cantonese-Chinese NIHSS.

Table 3 shows the range of scores obtained from each item of all six cases of PC-NIHSS videos. Except for a score of 3 on item 1a, all possible responses on individual scale items were included in group A certification cases of PC-NIHSS videos. The total score of these six cases, in mean±SD, ranged from 1.8±1.2 to 29.3±2.6, and, in median, from 2–29. (Table 4)

Table 3.

Distribution of responses by individual items of PC-NIHSS videos*

Level of responses, number (%)
Item number and name Total responses on the item 0 1 2 3 4
1a LOC 1770 1474 (83.3) 274 (15.5) 22 (1.2) 0 (0.0)
1b LOC questions 1769 898 (50.8) 288 (16.3) 583 (33.0)
1c LOC command 1770 1481 (83.7) 286 (16.2) 3 (0.2)
2 Gaze 1770 1235 (69.8) 354 (20.0) 181 (10.2)
3 Visual fields 1770 1415 (79.9) 84 (4.7) 132 (7.5) 139 (7.9)
4 Facial weakness 1770 678 (38.3) 538 (30.4) 285 (16.1) 269 (15.2)
5a Motor left arm 1770 1283 (72.5) 188 (10.6) 7 (0.4) 4 (0.2) 288 (16.3)
5b Motor right arm 1770 629 (35.5) 716 (40.5) 391 (22.1) 30 (1.7) 4 (0.2)
6a Motor left leg 1770 1338 (75.6) 136 (7.7) 3 (0.2) 4 (0.2) 289 (16.3)
6b Motor right leg 1769 602 (34.0) 576 (32.6) 237 (13.4) 73 (4.1) 281 (15.9)
7 Ataxia 1768 538 (30.4) 656 (37.1) 574 (32.5)
8 Sensory 1767 1145 (64.8) 619 (35.0) 3 (0.2)
9 Aphasia 1770 756 (42.7) 727 (41.1) 276 (15.6) 11 (0.6)
10 Dysarthria 1770 1031 (58.2) 638 (36.0) 101 (5.7)
11 Extinction 1770 1270 (71.8) 336 (19.0) 164 (9.3)
*

This table shows 15 NIHSS items and level of responses to each item by 295 raters on PC-NIHSS group A cases. Unequal total responses to items are due to missing values. The percentages do not add to 100 because of rounding. Level of responses corresponds to the available responses for each item; some items have three and others have four or five possible responses.

–, response unavailable;

PC-NIHSS, Putonghua-Chinese NIHSS.

Table 4.

Distribution of responses by individual items of CC-NIHSS videos*

Level of responses, number (%)
Item number and name Total responses on the item 0 1 2 3 4
1a LOC 1884 1307 (69.4) 540 (28.7) 36 (1.9) 1 (0.1)
1b LOC questions 1884 340 (18.0) 1397 (74.2) 147 (7.8)
1c LOC command 1884 1559 (82.7) 257 (13.6) 68 (3.6)
2 Gaze 1883 994 (52.8) 755 (40.1) 134 (7.1)
3 Visual fields 1884 1320 (70.1) 374 (19.9) 161 (8.5) 29 (1.5)
4 Facial weakness 1884 368 (19.5) 526 (27.9) 716 (38.0) 274 (14.5)
5a Motor left arm 1884 1335 (70.9) 236 (12.5) 0 (0.0) 30 (1.6) 283 (15.0)
5b Motor right arm 1884 732 (38.9) 1119 (59.4) 32 (1.7) 1 (0.1) 0 (0.0)
6a Motor left leg 1884 1080 (57.3) 481 (25.5) 9 (0.5) 2 (0.1) 312 (16.6)
6b Motor right leg 1884 647 (34.3) 908 (48.2) 320 (17.0) 9 (0.5) 0 (0.0)
7 Ataxia 1884 948 (50.3) 552 (29.3) 384 (20.4)
8 Sensory 1884 1551 (82.3) 323 (17.1) 10 (0.5)
9 Aphasia 1884 433 (23.0) 831 (44.1) 611 (32.4) 9 (0.5)
10 Dysarthria 1884 426 (22.6) 1114 (59.1) 344 (18.3)
11 Extinction 1884 1496 (79.4) 186 (9.9) 202 (10.7)
*

This table shows the 15 NIHSS items and the level of responses to each item by 314 raters on CC-NIHSS group A cases. Unequal total responses to items are due to missing values. The percentages do not add to 100 because of rounding. Level of responses corresponds to the available responses for each item; some items have three and others have four or five possible responses.

–, response unavailable;

CC-NIHSS, Cantonese-Chinese NIHSS.

For PC-NIHSS videos, facial palsy and limb ataxia (13%) showed poor agreement, nine items (60%) showed moderate agreement, and four items (27%) showed excellent agreement When compared with E-NIHSS videos, the agreements on best gaze, visual fields, facial weakness or aphasia were less well with PC-NIHSS videos; the agreement on consciousness questions was better in PC-NIHSS videos (Table 5). Intraclass correlation coefficient of total score of PC-NIHSS videos was 0.97 (95% CI 0.64–0.98), and was not statistically different from E-NIHSS videos (0.94; P =0.494) (10). For CC-NIHSS videos, facial palsy and limb ataxia (13%) showed poor agreement, 10 items (67%) showed good agreement, and three items (20%) showed excellent agreement. When compared with E-NIHSS videos, the agreements on consciousness commands and visual fields were less well in CC-NIHSS videos (Table 5). ICC of total score of CC-NIHSS videos was 0.95 (95% CI 0.77–0.97), and this was not statistically different from that of E-NIHSS videos (P =0.906) (10).

Table 5.

Interobserver agreement on individual scale items for PC-NIHSS or CC-NIHSS videos as compared to E-NIHSS videos*

PC-NIHSS
CC-NIHSS
Item number and name κ CI κ CI E-NIHSS κ
1a LOC 0.49 0.14–0.64 0.49 0.17–0.73 0.46
1b LOC questions 0.97 0.91–0.99 0.74 0.00–0.98 0.77
1c LOC command 0.93 0.00–0.94 0.77 0.00–0.79 0.92
2 Gaze 0.60 0.04–0.67 0.70 0.06–0.87 0.70
3 Visual fields 0.55 0.00–0.65 0.49 0.02–0.57 0.72
4 Facial weakness 0.31 0.08–0.35 0.28 0.04–0.44 0.38
5a Motor left arm 0.72 0.00–0.92 0.75 0.01–0.87 0.65
5b Motor right arm 0.61 0.26–0.77 0.60 0.03–0.73 0.72
6a Motor left leg 0.64 0.01–0.87 0.74 0.20–0.91 0.64
6b Motor right leg 0.77 0.55–0.84 0.73 0.43–0.82 0.64
7 Ataxia 0.28 0.08–0.42 0.29 0.12–0.38 0.21
8 Sensory 0.85 0.01–0.92 0.87 0.00–0.94 0.73
9 Aphasia 0.42 0.07–0.58 0.49 0.07–0.69 0.64
10 Dysarthria 0.45 0.09–0.56 0.70 0.07–0.87 0.56
11 Extinction 0.59 0.00–0.64 0.55 0.01–0.68 0.57
*

Table shows the agreement (unweighted κ) and 95% CI among raters for 15 NIHSS items using PC-NIHSS or CC-NIHSS videos. κ<0.40 defines poor agreement, 0.40≤κ≤0.75 defines moderate agreement, and κ>0.75 defines excellent agreement. The agreements on individual items among raters using E-NIHSS videos are given for comparison (10).

E-NIHSS, English language NIHSS; CC-NIHSS, Cantonese-Chinese NIHSS; PC-NIHSS, Putonghua-Chinese NIHSS.

Discussion

All possible responses on individual scale items, except for a score of 3 on item 1a, are included in PC-NIHSS group A cases. The rules to give a score of 3 on item 1a are nonambiguous; this item score is included in a PC-NIHSS nongroup A case. Except for a score of 2 on item 5a and a score of 4 on items 5b and 6b, all possible responses on all individual scale items are included in group A cases of CC-NIHSS videos. Such omissions are acceptable as all possible responses are illustrated when motor items of all four limbs are considered together. Thus, group A certification cases of both PC-NIHSS and CC-NIHSS videos have content validity.

In terms of inter-rater reliability of PC-NIHSS and CC-NIHSS videos, the agreements are good or excellent on 13 out of 15 items, but poor on facial palsy (item 4) and limb ataxia (item 7). These findings replicate those of E-NIHSS videos: facial palsy and limb ataxia (13%) have poor agreement; 11 items (73%) have good agreement; and two items (13%) have excellent agreement (10). When κ coefficients of individual scale items are compared between PC-NIHSS and E-NIHSS videos, the agreements on best gaze, visual fields, facial weakness and aphasia are less well but the agreement on consciousness questions is better in PC-NIHSS group A cases. Similarly, the agreement in commands for the level of consciousness and visual fields may be less well in the group A cases of CC-NIHSS videos than that of the 18 certification cases of E-NIHSS videos. At present we have no explanation for such differences. Groups B and C cases of PC-NIHSS and CC-NIHSS videos should be evaluated in future workshops to allow comparison of κ coefficients of scale items between the groups B and C cases and E-NIHSS certification cases. There is no difference in ICC of total score between PC-NIHSS and E-NIHSS videos as well as between CC-NIHSS and E-NIHSS videos.

Fewer nurses than doctors attended the workshops using PC-NIHSS videos as assessment of stroke deficits, such as NIHSS, is performed by medical doctors but not nurses in Mainland China. In contrast, nurses in Hong Kong are willing to perform assessments such as Glasgow coma scale and NIHSS. Raters of the workshops in Mainland China are younger than those in Hong Kong. Nevertheless, workshop attendees are typical stroke care providers in Mainland China and Hong Kong, and most raters have had working experience in the hospital and with stroke patients.

Whereas a third to half of raters have previously performed NIHSS assessment on their patients, only a tenth were formally trained using E-NIHSS videos; language barrier is a possible explanation. A high pass rate of 80% is obtained using PC-NIHSS or CC-NIHSS videos, suggesting an advantage of using the native language in training and certification of stroke assessment scales. Another study involving naïve users will be required to show whether training with PC-NIHSS or CC-NIHSS videos would facilitate certification among healthcare workers speaking Putonghua or Cantonese when compared with E-NIHSS training videos. Nevertheless, previous formal training using E-NIHSS videos is not associated with a pass. A plausible explanation is the small number of raters with formal training.

Both PC-NIHSS and CC-NIHSS videos have good content validity and inter-rater reliability comparable to those of E-NIHSS videos. Similar to E-NIHSS videos, PC-NIHSS and CC-NIHSS videos will be saved on DVDs and made available online for single user to view at home or in office as well as for multiple users to view in a training and certification workshop. Availability of PC-NIHSS and CC-NIHSS videos should lead to wider use of NIHSS among stroke care providers in Putonghua- and Cantonese-speaking communities. If the current approach turns out to be superior to simple translations of E-NIHSS videos from English into non-English languages, there may be a need to create new NIHSS training and certification videos in other widely spoken languages.

Acknowledgments

This paper was supported by S. K. Yee Medical Foundation, Hong Kong (project no. 205257).

Footnotes

There are no conflicts of interest to disclose.

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