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. 1989 Apr;86(7):2204–2208. doi: 10.1073/pnas.86.7.2204

On the origin and transmission of force in actomyosin subfragment 1.

J Botts 1, J F Thomason 1, M F Morales 1
PMCID: PMC286880  PMID: 2928326

Abstract

A proximity map showing the three-dimensional arrangement of 12 chemically defined points in actomyosin subfragment 1 is developed and roughly correlated with published electron microscope reconstruction of others. Several additional points and topological relationships in the primary polypeptide chain folding are assimilated into this model. Certain crosslinkings and distance change observations are interpreted as indicators of transmission of force/displacement between the nucleotide-binding and an actin-binding site--i.e., as indications of how energy is transduced in this system.

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Selected References

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