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. Author manuscript; available in PMC: 2010 Aug 11.
Published in final edited form as: Nature. 2010 Feb 11;463(7282):769–774. doi: 10.1038/nature08758

Figure 1. BDZ-evoked synaptic plasticity is abolished in α1(H101R) mutant mice.

Figure 1

a, Top panel; normalized AMPAR-EPSCs obtained at -65, 0 and +35 mV in slices from WT mice i.p. injected with saline, MDZ (0.5 mg/kg) or Mor (15 mg/kg) 24 h prior to sacrifice. Middle panel; corresponding iv-curves. Bottom panel; bar graphs represent group data for the RI. F(2;21) = 9.08. b, AMPAR-EPSCs, iv-curves and RI (top, middle and bottom panel, respectively) observed when ACSF or MDZ were injected into the VTA in WT mice. t(11) = 5.43. c, Similar experiments performed with α1(H101R) mice. Note that Mor induces a rectification that is similar in WT and mutant mice. F(2;16) = 17.88. d, Similar experiments performed with α1(H101R) mice when MDZ was injected intra-VTA. n = 6-10.