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American Journal of Alzheimer's Disease and Other Dementias logoLink to American Journal of Alzheimer's Disease and Other Dementias
. 2010 May;25(3):233–238. doi: 10.1177/1533317509357736

Effects of Apolipoprotein E-ε4 and -ε2 in Amnestic Mild Cognitive Impairment and Dementia in Shanghai: SCOBHI-P

Amy R Borenstein 1, James A Mortimer 2, Ding Ding 3, Gerard D Schellenberg 4, Charles DeCarli 5, Qianhua Zhao 6, Cathleen Copenhaver 7, Qihao Guo 8, Shugang Chu 9, Douglas Galasko 10, David P Salmon 11, Qi Dai 12, Yougui Wu 13, Ronald Petersen 14, Zhen Hong 15
PMCID: PMC2872993  NIHMSID: NIHMS197902  PMID: 20142627

Abstract

Objective: To determine apolipoprotein E (APOE)-ε4 and -ε2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China. Methods: A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods. Results: Among controls, frequencies were ε2, 0.11; ε3, 0.84; and ε4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any ε4 allele. The ε2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61). Conclusions: APOE-ε4 increases and -ε2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).

Keywords: apolipoprotein E, dementia, mild cognitive impairment, China

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Contributor Information

Amy R. Borenstein, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA, aborenst@health.usf.edu .

James A. Mortimer, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.

Ding Ding, University of Fudan School of Public Health, Huashan Hospital, Shanghai, China.

Gerard D. Schellenberg, University of Pennsylvania, Philadelphia, PA, USA.

Charles DeCarli, University of California-Davis, Sacaramento, CA, USA.

Qianhua Zhao, University of Fudan School of Public Health, Huashan Hospital, Shanghai, China.

Cathleen Copenhaver, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.

Qihao Guo, University of Fudan School of Public Health, Huashan Hospital, Shanghai, China.

Shugang Chu, University of Fudan School of Public Health, Huashan Hospital, Shanghai, China.

Douglas Galasko, University of California-San Diego, San Diego, CA, USA.

David P. Salmon, University of California-San Diego, San Diego, CA, USA.

Qi Dai, Vanderbilt University, Nashville, TN, USA.

Yougui Wu, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.

Ronald Petersen, Mayo Clinic, Rochester, MN, USA.

Zhen Hong, University of Fudan School of Public Health, Huashan Hospital, Shanghai, China.

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