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. 1989 Jun;86(12):4644–4648. doi: 10.1073/pnas.86.12.4644

Quantifying the infectivity of human immunodeficiency virus.

S P Layne 1, J L Spouge 1, M Dembo 1
PMCID: PMC287327  PMID: 2734313

Abstract

We have developed a mathematical model that quantifies lymphocyte infection by human immunodeficiency virus (HIV) and lymphocyte protection by blocking agents such as soluble CD4. We use this model to suggest standardized parameters for quantifying viral infectivity and to suggest techniques for calculating these parameters from well-mixed infectivity assays. We discuss the implications of the model for our understanding of the infectious process and virulence of HIV in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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