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. 1989 Jun;86(11):4331–4333. doi: 10.1073/pnas.86.11.4331

Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl phosphorofluoridate administration.

G B Koelle 1, M S Han 1
PMCID: PMC287446  PMID: 2726774

Abstract

Rats were given glycyl-L-glutamine (Gly-Gln) by intraaortic infusion with Alzet osmotic pumps during the 48-hr period following the intraaortic administration of diisopropyl phosphorofluoridate (DFP) (10 mumol/kg). The infusion of 1.2 mumol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 mumol per 24 hr, a diminished result was obtained; at 0.36 mumol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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