TABLE 2.

Quantity (total mg/kg) of additives infused during a transfusion of 15 mL per kg AS-1 or AS-3 RBCs at a Hct level of 60%

Additive	AS-1	AS-3	Toxic dose*
Sodium chloride	42	7.5	137 mg/kg/day
Dextrose	129	23	240 mg/kg/hr
Adenine	0.6	0.6	15 mg/kg/dose
Citrate	9.8	12.6	180 mg/kg/hr
Phosphate	2.0	5.6	>60 mg/kg/day
Mannitol	33	0	360 mg/kg/day

^*The accuracy of toxic dose is difficult to predict because RBC infusion rates are slow, allowing metabolism and distribution of additives into extravascular sites. In addition, dextrose, adenine, and phosphate enter RBCs and are somewhat sequestered and not immediately “available” in the extracellular solution. Potential toxic doses from Luban et al.²⁴