Abstract
If an implantable artificial heart can be developed, it should prove beneficial to a significant group of patients. A variety of energy sources, such as biologic, electromagnetic, and nuclear, are under evaluation. Currently, biologic fuel cell technology is not sufficiently advanced to permit its extrapolation to the power levels required for implantable circulatory support systems. Electromagnetic systems have the disadvantage of heavy batteries of considerable bulk requiring frequent recharging. Radioisotope-fueled thermal engine systems have the potential of providing degrees of freedom not possible with rechargeable units. However, radiosotope circulatory support systems subject their recipients to prolonged intracorporeal radiation, add to environmental background radiation, and constitute an exceedingly small, but finite, hazard due to possible violation of fuel containment.
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Selected References
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- BRECHER G., BRAMBEL C. E., BRAMBEL F. D. PATTERNS OF HEMOPOIETIC RESPONSE TO CONTINUOUS WHOLE-BODY IRRADIATION. Ann N Y Acad Sci. 1964 Mar 31;114:549–556. doi: 10.1111/j.1749-6632.1964.tb53607.x. [DOI] [PubMed] [Google Scholar]
- Norman J. C., Harmison L. T., Huffman F. N. Nuclear-fueled circulatory support systems. Arch Surg. 1972 Oct;105(4):645–647. doi: 10.1001/archsurg.1972.04180100088021. [DOI] [PubMed] [Google Scholar]
- Norman J. C., Molokhia F. A., Harmison L. T., Whalen R. L., Huffman F. N. An implantable nuclear-fueled circulatory support system. I. Systems analysis of conception, design, fabrication and initial in vivo testing. Ann Surg. 1972 Oct;176(4):492–502. doi: 10.1097/00000658-197210000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PONTIFEX A. H., LAMERTON L. F. Effects of protracted irradiation on the blood-forming organs of the rat. II. Divided doses. Br J Radiol. 1960 Dec;33:736–747. doi: 10.1259/0007-1285-33-396-736. [DOI] [PubMed] [Google Scholar]
- Sandberg G. W., Jr, Huffman F. N., Norman J. C. Experimental observations of intracorporeal strontium 90-americium 241/beryllium sources simulating radiation fields from nuclear-powered artificial hearts. Ann Thorac Surg. 1970 May;9(5):401–409. doi: 10.1016/s0003-4975(10)65530-0. [DOI] [PubMed] [Google Scholar]