Table 2.
Genotype distribution and odds ratios (95% CI) for associations between HPN genotypes and prostate cancer risk by race
| SNP | Genotype | Caucasians | African Americans | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases (%) (n=1,258)a | Controls (%) (n=1,241)a | Adjusted ORb (95% CI) | Ptrendc | Cases (%) (n=143)a | Controls (%) (n=80)a | Adjusted ORb (95% CI) | Ptrendc | ||
| rs12461158 | GG | 692(55.4) | 651(52.4) | ref | 71(50.0) | 41(51.3) | ref | ||
| AG | 476(38.1) | 506(40.7) | 0.89 (0.75–1.04) | 56(39.4) | 33(41.3) | 0.97 (0.52–1.78) | |||
| AA | 81(6.5) | 85(6.8) | 0.90 (0.65–1.24) | 15(10.6) | 6(7.5) | 1.35 (0.47–3.88) | |||
| AA+AG | 0.89 (0.76–1.04) | 0.18 | 1.03 (0.58–1.84) | 0.72 | |||||
| rs2451996 | TT | 425(34.2) | 409(33.1) | ref | 14(9.9) | 7(8.8) | ref | ||
| CT | 612(49.3) | 593(48.0) | 0.99 (0.83–1.18) | 49(34.5) | 42(52.5) | 0.46 (0.16–1.35) | |||
| CC | 204(16.4) | 233(18.9) | 0.84 (0.67–1.06) | 79(55.6) | 31(38.8) | 1.16 (0.40–3.33) | |||
| CC+CT | 0.95 (0.80–1.12) | 0.20 | 0.76 (0.28–2.08) | 0.09 | |||||
| rs1688043 | AA | 1,089(88.0) | 1,084(88.0) | ref | 95(67.9) | 57(73.1) | ref | ||
| AG | 145(11.7) | 142(11.5) | 1.01 (0.79–1.30) | 40(28.6) | 21(26.9) | -- | |||
| GG | 4(0.3) | 6(0.5) | 0.66 (0.19–2.34) | 5(3.6) | 0(0.0) | -- | |||
| GG+AG | 1.00 (0.78–1.27) | 0.90 | 1.23 (0.65–2.35) | ||||||
| rs2305746 | GG | 1,093(88.0) | 1,093(88.1) | ref | 88(62.0) | 55(68.8) | ref | ||
| AG | 145(11.7) | 141(11.4) | 1.03 (0.80–1.31) | 47(33.1) | 22(27.5) | 1.23 (0.65–2.34) | |||
| AA | 4(0.3) | 7(0.6) | 0.57 (0.17–1.94) | 7(4.9) | 3(3.8) | 1.24 (0.30–5.19) | |||
| AA+AG | 1.00 (0.79–1.28) | 0.88 | 1.23 (0.67–2.27) | 0.53 | |||||
| rs2305747 | TT | 668(54.5) | 673(55.0) | ref | 22(15.5) | 12(15.0) | ref | ||
| CT | 485(39.6) | 457(37.3) | 1.07 (0.91–1.26) | 62(43.7) | 48(60.0) | 0.64 (0.27–1.49) | |||
| CC | 73(6.0) | 94(7.7) | 0.78 (0.56–1.08) | 58(40.8) | 20(25.0) | 1.49 (0.60–3.71) | |||
| CC+CT | 1.02 (0.87–1.20) | 0.62 | 0.89 (0.40–2.00) | 0.15 | |||||
| rs1688029 | AA | 571(47.3) | 571(47.0) | ref | 17(12.2) | 10(12.5) | ref | ||
| AG | 520(43.0) | 517(42.6) | 1.00 (0.85–1.19) | 51(36.7) | 39(48.8) | 0.64 (0.25–1.65) | |||
| GG | 117(9.7) | 126(10.4) | 0.93 (0.70–1.23) | 71(51.1) | 31(38.8) | 1.26 (0.49–3.26) | |||
| GG+AG | 0.99 (0.84–1.16) | 0.72 | 0.91 (0.37–2.23) | 0.19 | |||||
a
Variable numbers of cases and controls reflect failed genotyping.
b
Adjusted for age. If there are no case or control homozygote carriers of the less common allele, then only the dominant model risk estimate is shown.
c
Analysis for linear trend according to the number of variant alleles. If there are homozygote carriers of the less common allele this analysis is omitted.