Time-domain parameters of HRV in the WT and in the KO mice, including: N-N (difference in R-R between consecutive beats) (A), SDNN (sd of N-N) (B), CVNN (coefficient of variation of N-N) (C), NN7% (% of consecutive beats more than 7 msec different in R-R) (D), and RMSSD (root mean square of sd of N-N) (E). N.S., Not significant (P > 0.05).