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. 1978 Jun;5(2):172–186.

THEORETICAL DESIGN CONSIDERATIONS AND PHYSIOLOGIC PERFORMANCE CRITERIA FOR AN IMPROVED INTRACORPOREAL (ABDOMINAL) ELECTRICALLY ACTUATED LONG-TERM LEFT VENTRICULAR ASSIST DEVICE (“E-TYPE” ALVAD) OR PARTIAL ARTIFICIAL HEART

Stephen R Igo 1, C Wayne Hibbs 1, John M Fuqua 1, Ruben Trono 1, Charles H Edmonds 1, John C Norman 1
PMCID: PMC287725  PMID: 15216070

Abstract

Our laboratories are engaged in the design of a clinically-oriented electrically actuated long-term intracorporeal (abdominal) left ventricular assist device (“E-type” ALVAD) or partial artificial heart. This infradiaphragmatic blood pump is designed to be powered by implantable electrical to mechanical energy converter systems.

The following analyses were undertaken to: [List: see text]

The proposed “E-type” ALVAD should be capable of pumping 4-7 liters per minute at heart rates of 75-100 beats per minute during rest, and 10 liters per minute at rates of 120 beats per minute during moderate exercise. These performance levels should be exceeded with a maximum device stroke volume of 85-90 ml and a mean pump inflow (filling) impedance of ≤ 0.072 gm/sec/cm−5.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aldrich J. G., Chambers J. A., Daly B. D., Migliore J. J., Newgard P., Huffman F. N., Norman J. C. An electrically actuated left ventricular assist device (E-A LVAD) in vivo testing. Trans Am Soc Artif Intern Organs. 1974;20 B:655–659. [PubMed] [Google Scholar]
  2. Chatterjee K., Parmley W. W., Ganz W., Forrester J., Walinsky P., Crexells C., Swan H. J. Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction. Circulation. 1973 Dec;48(6):1183–1193. doi: 10.1161/01.cir.48.6.1183. [DOI] [PubMed] [Google Scholar]
  3. Daly B. D., Hagen K. G., Fuqua J. M., Igo S. R., Huffman F. N., Norman J. C. A pusher plate pump for tatally implantable left ventricular assist device systems. J Surg Res. 1975 Jun;18(6):597–605. doi: 10.1016/0022-4804(75)90024-4. [DOI] [PubMed] [Google Scholar]
  4. Hughes D. A., Faeser R. J., Daly B. D., Edmonds C. H., Feigenbutz L. V., Igo S. R., Hagen K., Migliore J. J., Ruggles A. E., Robinson W. J. Nuclear-fueled circulatory support systems XII: current status. Trans Am Soc Artif Intern Organs. 1974;20 B:737–746. [PubMed] [Google Scholar]
  5. Hughes D. A., Igo S. R., Daly B. D., Migliore J. J., Norman J. C. Effects of an abdominal left ventricular assist device on myocardial oxygen supply/demand ratios in normally perfused and ischemic bovine myocardium. Ann Thorac Surg. 1975 Mar;19(3):301–308. doi: 10.1016/s0003-4975(10)64021-0. [DOI] [PubMed] [Google Scholar]
  6. Igo S. R., Hibbs C. W., Fuqua J. M., Walker M. G., Naifeh J. G., Norman J. C. Chronic evaluations of ventricular ejection phase dynamics during abdominal left ventricular assist device (ALVAD) pumping in the awake, unanesthetized calf. Trans Am Soc Artif Intern Organs. 1976;22:480–488. [PubMed] [Google Scholar]
  7. Norman John C. AN INTRACORPOREAL (ABDOMINAL) LEFT VENTRICULAR ASSIST DEVICE [ALVAD], XXX: CLINICAL READINESS AND INITIAL TRIALS IN MAN. Cardiovasc Dis. 1976;3(3):249–288. [PMC free article] [PubMed] [Google Scholar]
  8. Norman John C. HEMODYNAMIC EFFECTS OF INTRACORPOREAL (ABDOMINAL) LEFT VENTRICULAR ASSIST DEVICE (ALVAD) PUMPING IN MAN, XL. Cardiovasc Dis. 1976;3(4):444–466. [PMC free article] [PubMed] [Google Scholar]
  9. Robinson W. J., Benedict B. S., Daly D. T., Hughes D. A., Migliore J. J., Hibbs C. W., Igo S. R., Norman J. C. An abdominal left ventricular assist device: preclinical studies. Ann Thorac Surg. 1975 May;19(5):540–551. doi: 10.1016/s0003-4975(10)64430-x. [DOI] [PubMed] [Google Scholar]
  10. Robinson W. J., Igo S. R., Daly B. D., Migliore J. J., Hughes D. A., Edmonds C. H., Fuqua J. M., Jr, Huffman F. N., Norman J. C. An abdominal left ventricular assist device (ALVAD): chronic hemodynamic analyses in the calf. Trans Am Soc Artif Intern Organs. 1974;20 B:709–720. [PubMed] [Google Scholar]
  11. Urschel C. W., Eber L., Forrester J., Matloff J., Carpenter R., Sonnenblick E. Alteration of mechanical performance of the ventricle by intraaortic balloon counterpulsation. Am J Cardiol. 1970 May;25(5):546–551. doi: 10.1016/0002-9149(70)90593-x. [DOI] [PubMed] [Google Scholar]
  12. Walker William E. IMPLICATIONS OF STUDIES OF VASCULAR IMPEDANCE FOR ASSESSMENT OF LEFT VENTRICULAR FUNCTION. Cardiovasc Dis. 1974;1(2):127–136. [PMC free article] [PubMed] [Google Scholar]

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