Skip to main content
PMC home page
Cardiovascular Diseases logoLink to Cardiovascular Diseases
. 1979 Mar;6(1):50–54.

FAMILIAL VALVULAR PULMONIC STENOSIS INVOLVING THREE SIBLINGS

Galal M El-Said 1, Mohamed El-Guindy 1, M Mohsen Ibrahim 1, A A El-Sherif 1
PMCID: PMC287766  PMID: 15216025

Abstract

This report describes the cases of three mentally and physically well-developed siblings, 12, 10, and 8 years of age, with varying degrees of isolated valvular pulmonic stenosis not related to age. The severest lesion occurred in the middle patient and was associated with a right-to-left shunt through a patent foramen ovale. The three children had no other siblings, and there was no history of congenital heart disease among close relatives. These cases support the conclusion that genetic factors play a significant role in the development of certain congenital cardiac disorders.

Full text

PDF
50

Images in this article

51Image
on p.51
52Image
on p.52
52Image
on p.52

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CAMPBELL M. Place of maternal rubella in the aetiology of congenital heart disease. Br Med J. 1961 Mar 11;1(5227):691–696. doi: 10.1136/bmj.1.5227.691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. EDWARDS J. H. The simulation of mendelism. Acta Genet Stat Med. 1960;10:63–70. doi: 10.1159/000151119. [DOI] [PubMed] [Google Scholar]
  3. Ehlers K. H., Engle M. A. Familial congenital heart disease. I. Genetic and environmental factors. Circulation. 1966 Sep;34(3):503–516. doi: 10.1161/01.cir.34.3.503. [DOI] [PubMed] [Google Scholar]
  4. Emerit I., de Grouchy J., Vernant P., Corone P. Chromosomal abnormalities and congenital heart disease. Circulation. 1967 Dec;36(6):886–905. doi: 10.1161/01.cir.36.6.886. [DOI] [PubMed] [Google Scholar]
  5. MCKUSICK V. A. A GENETICAL VIEW OF CARDIOVASCULAR DISEASE. THE LEWIS A. CONNER MEMORIAL LECTURE. Circulation. 1964 Sep;30:326–357. doi: 10.1161/01.cir.30.3.326. [DOI] [PubMed] [Google Scholar]
  6. Moller I., Wennevold A., Lyngborg K. E. The natural history of pulmonary stenosis. Long-term follow-up with serial heart catheterizations. Cardiology. 1973;58(4):193–202. doi: 10.1159/000169634. [DOI] [PubMed] [Google Scholar]
  7. Nora J. J., Gilliland J. C., Sommerville R. J., McNamara D. G. Congenital heart disease in twins. N Engl J Med. 1967 Sep 14;277(11):568–571. doi: 10.1056/NEJM196709142771104. [DOI] [PubMed] [Google Scholar]
  8. Nora J. J., McGill C. W., McNamara D. G. Empiric recurrence risks in common and uncommon congenital heart lesions. Teratology. 1970 Nov;3(4):325–330. doi: 10.1002/tera.1420030408. [DOI] [PubMed] [Google Scholar]
  9. Nora J. J., Meyer T. C. Familial nature of congenital heart diseases. Pediatrics. 1966 Feb;37(2):329–334. [PubMed] [Google Scholar]
  10. Nora J. J. Multifactorial inheritance hypothesis for the etiology of congenital heart diseases. The genetic-environmental interaction. Circulation. 1968 Sep;38(3):604–617. doi: 10.1161/01.cir.38.3.604. [DOI] [PubMed] [Google Scholar]
  11. Nora J. J., Nora A. H. The evolution of specific genetic and environmental counseling in congenital heart diseases. Circulation. 1978 Feb;57(2):205–213. doi: 10.1161/01.cir.57.2.205. [DOI] [PubMed] [Google Scholar]
  12. TAUSSIG H. B. A study of the German outbreak of phocomelia. The thalidomide syndrome. JAMA. 1962 Jun 30;180:1106–1114. [PubMed] [Google Scholar]
  13. Tsagaris T. J., Bustamante R. A., Friesendorff R. A. Familial heart disease. Dis Chest. 1967 Aug;52(2):153–158. doi: 10.1378/chest.52.2.153. [DOI] [PubMed] [Google Scholar]

Articles from Cardiovascular Diseases are provided here courtesy of Texas Heart Institute

RESOURCES