Skip to main content
Cardiovascular Diseases logoLink to Cardiovascular Diseases
. 1981 Mar;8(1):73–83.

Hypertrophic cardiomyopathy associated with left ventricular aneurysm and normal coronary arteries: Case study indicating genetic tendencies of cardiomyopathy

C Saenz De La Calzada 1, A Llovet Verdugo 1, J Tascon Perez 1, C Castro Alcaine 1, A Sanchez Fernandez 1
PMCID: PMC287903  PMID: 15216229

Abstract

A 50-year-old man presented with hypertrophic obstructive cardiomyopathy (HOC) associated with a left ventricular aneurysm and normal coronary arteries. His history revealed no evidence of myocardial infarction or atypical angina. Physical examination disclosed HOC but did not suggest the presence of an aneurysm. Although the patient was treated medically, heart failure ensued, and he died suddenly while working his farm. Subsequent investigation of the patient's family revealed that three of his five children were also affected by cardiomyopathy, which was especially pronounced in the eldest, a 22-year-old man.

The possible hemodynamic relationship between HOC and left ventricular aneurysm is discussed, along with probable indications. The role of left ventricular aneurysm is also presented in relation to the natural history of the disease.

Full text

PDF
73

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnett E. N., Roberts W. C. Acute myocardial infarction and angiographically normal coronary arteries. An unproven combination. Circulation. 1976 Mar;53(3):395–400. doi: 10.1161/01.cir.53.3.395. [DOI] [PubMed] [Google Scholar]
  2. Asymmetric septal hypertrophy. Ann Intern Med. 1974 Nov;81(5):650–680. doi: 10.7326/0003-4819-81-5-650. [DOI] [PubMed] [Google Scholar]
  3. De la Calzada C. S., Ziady G., Georgios V., Hardarson T. Proceedings: Echocardiographic features of hypertrophic obstructive cardiomyopathy. Br Heart J. 1974 Apr;36(4):396–396. [PubMed] [Google Scholar]
  4. DeMaria A. N., Miller R. R., Amsterdam E. A., Markson W., Mason D. T. Mitral valve early diastolic closing velocity in the echocardiogram: relation to sequential diastolic flow and ventricular compliance. Am J Cardiol. 1976 Apr;37(5):693–700. doi: 10.1016/0002-9149(76)90362-3. [DOI] [PubMed] [Google Scholar]
  5. Faruqui A. M., Maloy W. C., Felner J. M., Schlant R. C., Logan W. D., Symbas P. Symptomatic myocardial bridging of coronary artery. Am J Cardiol. 1978 Jun;41(7):1305–1310. doi: 10.1016/0002-9149(78)90890-1. [DOI] [PubMed] [Google Scholar]
  6. Frank S., Braunwald E. Idiopathic hypertrophic subaortic stenosis. Clinical analysis of 126 patients with emphasis on the natural history. Circulation. 1968 May;37(5):759–788. doi: 10.1161/01.cir.37.5.759. [DOI] [PubMed] [Google Scholar]
  7. Glancy D. L., O'Brien K. P., Gold H. K., Epstein S. E. Atrial fibrillation in patients with idiopathic hypertrophic subaortic stenosis. Br Heart J. 1970 Sep;32(5):652–659. doi: 10.1136/hrt.32.5.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goodwin J. F. Prospects and predictions for the cardiomyopathies. Circulation. 1974 Aug;50(2):210–219. doi: 10.1161/01.cir.50.2.210. [DOI] [PubMed] [Google Scholar]
  9. Greenwald J., Yap J. F., Franklin M., Lichtman A. M. Echocardiographic mitral systolic motion in left ventricular aneurysm. Br Heart J. 1975 Jul;37(7):684–690. doi: 10.1136/hrt.37.7.684. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hamby R. I., Roberts G. S., Meron J. M. Hypertension and hypertrophic subaortic stenosis. Am J Med. 1971 Oct;51(4):474–481. doi: 10.1016/0002-9343(71)90253-1. [DOI] [PubMed] [Google Scholar]
  11. Hardarson T., De la Calzada C. S., Curiel R., Goodwin J. F. Prognosis and mortality of hypertrophic obstructive cardiomyopathy. Lancet. 1973 Dec 29;2(7844):1462–1467. doi: 10.1016/s0140-6736(73)92730-x. [DOI] [PubMed] [Google Scholar]
  12. Harrison E. E., Sbar S. S., Martin H., Pupello D. F. Coexisting right and left hypertrophic subvalvular stenosis and fixed left ventricular outflow obstruction due to aortic valve stenosis. Am J Cardiol. 1977 Jul;40(1):133–136. doi: 10.1016/0002-9149(77)90111-4. [DOI] [PubMed] [Google Scholar]
  13. Henning H., O'Rourke R. A., Crawford M. H., Righetti A., Karliner J. S. Inferior myocardial infarction as a cause of asymmetric septal hypertrophy. An echocardiographic study. Am J Cardiol. 1978 May 1;41(5):817–822. doi: 10.1016/0002-9149(78)90719-1. [DOI] [PubMed] [Google Scholar]
  14. Henry W. L., Clark C. E., Epstein S. E. Asymmetric septal hypertrophy. Echocardiographic identification of the pathognomonic anatomic abnormality of IHSS. Circulation. 1973 Feb;47(2):225–233. doi: 10.1161/01.cir.47.2.225. [DOI] [PubMed] [Google Scholar]
  15. Kronzon I., Glassman E. Mitral ring calcification in idiopathic hypertrophic subaortic stenosis. Am J Cardiol. 1978 Jul;42(1):60–66. doi: 10.1016/0002-9149(78)90986-4. [DOI] [PubMed] [Google Scholar]
  16. Maron B. J., Epstein S. E., Roberts W. C. Hypertrophic cardiomyopathy and transmural myocardial infarction without significant atherosclerosis of the extramural coronary arteries. Am J Cardiol. 1979 Jun;43(6):1086–1102. doi: 10.1016/0002-9149(79)90139-5. [DOI] [PubMed] [Google Scholar]
  17. Noble J., Bourassa M. G., Petitclerc R., Dyrda I. Myocardial bridging and milking effect of the left anterior descending coronary artery: normal variant or obstruction? Am J Cardiol. 1976 Jun;37(7):993–999. doi: 10.1016/0002-9149(76)90414-8. [DOI] [PubMed] [Google Scholar]
  18. Pichard A. D., Meller J., Teichholz L. E., Lipnik S., Gorlin R., Herman M. V. Septal perforator compression (narrowing) in idiopathic hypertrophic subaortic stenosis. Am J Cardiol. 1977 Sep;40(3):310–314. doi: 10.1016/0002-9149(77)90151-5. [DOI] [PubMed] [Google Scholar]
  19. Saenz de la Calzada C., Ziady G. M., Hardarson T., Curiel R., Goodwin J. F. Effect of acute administration of propranolol on ventricular function in hypertrophic obstructive cardiomyopathy measured by non-invasive techniques. Br Heart J. 1976 Aug;38(8):798–803. doi: 10.1136/hrt.38.8.798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Somerville J., Becú L. Congenital heart disease associated with hypertrophic cardiomyopathy. Br Heart J. 1978 Sep;40(9):1034–1039. doi: 10.1136/hrt.40.9.1034. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Spilkin S., Mitha A. S., Matisonn R. E., Chesler E. Complete heart block in a case of idiopathic hypertrophic subaortic stenosis: noninvasive correlates with the timing of atrial systole. Circulation. 1977 Feb;55(2):418–422. doi: 10.1161/01.cir.55.2.418. [DOI] [PubMed] [Google Scholar]
  22. Stewart S., Mason D. T., Braunwald E. Impaired rate of left ventricular filling in idiopathic hypertrophic subaortic stenosis and valvular aortic stenosis. Circulation. 1968 Jan;37(1):8–14. doi: 10.1161/01.cir.37.1.8. [DOI] [PubMed] [Google Scholar]

Articles from Cardiovascular Diseases are provided here courtesy of Texas Heart Institute

RESOURCES