Table 3.
Regions where brain activity correlated with white matter hyperintensities (WMH):
A. correlations with global WMH burden (n=25, threshold P<0.01 uncorrected); B. correlations with WMH burden in superior longitudinal fasciculus (SLF) (n=10, threshold P < 0.01 uncorrected). Coordinates are given in MNI space.
| Region | Coordinates | Z-Value | Voxel Level Significance (uncorrected) | ||
|---|---|---|---|---|---|
| x | y | z | |||
| A. Global WMH burden | |||||
| Positive Correlations: | |||||
| Cluster 1: Cerebellum and Brainstem; P<0.000 (corrected) | |||||
| Cerebellum, Anterior Lobe | −6,12 | −50, −46 | −24, −26 | 4.86,4.84* | |
| Cerebellum, Anterior Lobe | −24 | −44 | −26 | 3.25 | |
| Cerebellum, Posterior Lobe | 24,38 | −40, −60 | −32, −30 | 4.27,4.25 | |
| Cerebellum, Posterior Lobe | 10 | −60 | −38 | 4.02 | |
| Pons (PMC) | 8,0 | −28, −30 | −30, −32 | 3.58,3.48 | |
| Left Pons | −16 | −34 | −28 | 3.70 | |
| Midbrain (PAG) | −2 | −28 | −18 | 2.44 | |
| Cluster 2: SMA, Superior/Medial Frontal Gyrus adjacent to Dorsal ACG; P<0.000 (corrected) | |||||
| Postcentral Gyrus (BA3) | −56, −24 | −14, −32 | 22,64 | 4.08,3.60 | |
| Precentral Gyrus (BA 4) | −16, −32 | −20, −16 | 60,54 | 3.96,3.20 | |
| Precentral Gyrus (BA 6) | −48 | −6 | 22 | 3.19 | |
| Precentral Gyrus | 48,54 | 2,0 | 46,26 | 3.84,3.30 | |
| Medial Frontal Gyrus (BA 6) | 14, −10 | −20, −14 | 54,48 | 3.68,3.64 | |
| Medial Frontal Gyrus (BA 32) | 12 | 14 | 44 | 3.48 | |
| Superior Frontal Gyrus (BA 6) | 8,8 | 2,24 | 66,58 | 3.53,3.09 | |
| Anterior Cingulate Gyrus (BA24) | −20 | −12 | 44 | 3.77 | |
| Inferior Frontal Gyrus (BA 9) | −54 | 4 | 28 | 3.37 | |
| Left Insula (BA13) | −38 | −8 | 6 | 3.12 | |
| Paracentral Lobule (BA31) | 0 | −22 | 42 | 3.59 | |
| Superior Temporal Gyrus (BA 22) | −50 | −2 | 6 | 3.57 | |
| Other Regions: | |||||
| Middle frontal gyrus (BA 8) | 30 | 20 | 42 | 2.83 | 0.002 |
| Thalamus (ventral posterior lateral nucleus) | 18 | −20 | 6 | 2.99 | 0.001 |
| Midbrain, Red nucleus | 8 | −18 | −4 | 2.84 | 0.002 |
| Hippocampus/parahipocampus | 28 | −20 | −14 | 3.12 | 0.001 |
| Cuneus (BA18) | −2 | −94 | 10 | 3.15 | 0.001 |
| Negative Correlations: | |||||
| Anterior Cingulate Gyrus (BA 24) | 4 | 24 | −4 | 2.93 | 0.002 |
| Caudate | 12 | 26 | −4 | 2.72 | 0.002 |
| Precuneus (BA 7) | 4 | −62 | 32 | 2.66 | 0.004 |
| B. Superior Longitudinal Fasciculus (Entire Pathway) | |||||
| Negative Correlations: | |||||
| Cluster 1: Dorsal ACG/Medial Frontal Gyrus; P < 0.006 (uncorrected) | |||||
| Anterior Cingulate Gyrus (BA24/32) | 6, −4 | 22,24 | 24,36 | 3.53,3.44 | |
| Medial Frontal Gyrus (BA 9/8) | 10,4 | 38,26 | 28,38 | 3.15,3.06 | |
| ACG/BA 32 | −2,2 | 20,20 | 28,28 | 3.12,3.12 | |
| Other Regions: | |||||
| Left Parietal Lobe (Angular Gyrus/BA 39) | −42 | −58 | 36 | 4.21 | 0.000 |
| Inferior Frontal Gyrus/BA13 | 40 | 20 | 8 | 2.80 | 0.003 |
*
Significant after corrections for multiple comparisons (FWE, P < 0.05)