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. 1993 Apr;91(4):1598–1603. doi: 10.1172/JCI116366

Diaphragm mechanics in dogs with unilateral emphysema.

R D Hubmayr 1, G A Farkas 1, H Y Tao 1, G C Sieck 1, S S Margulies 1
PMCID: PMC288136  PMID: 8473503

Abstract

We studied dogs with unilateral papain-induced emphysema to answer two questions: (1) Do emphysema lung-apposed hemidiaphragm (DiE) and normal lung-apposed hemidiaphragm (DiN) have equal capacities for lowering lung surface pressure? and (2) Are side-to-side differences in intrathoracic pressure the result of unequal force outputs by DiE and DiN or are they caused by differences in their mechanical efficiency as pressure generators? After the airways of the emphysematous and normal lungs were intubated with a dual lumen endotracheal tube, both phrenic nerves were maximally stimulated at rates between 1 and 50 Hz and the changes in airway occlusion pressure (delta PaoE,N) and diaphragm length (sonomicrometry) were recorded. In all animals, delta PaoN exceeded delta PaoE. Differences in pressure ranged from 1.2 +/- 0.6 cm H2O during a twitch to 6.0 +/- 2.9 cm H2O during a 50-Hz tetanus. Midcostal bundles of DiE shortened less than corresponding bundles of DiN, but both reached the same active length relative to their optimal lengths, which were measured in vitro. There was no significant difference in fiber type distribution, fiber cross-sectional area, or maximal isometric tetanic tensions among midcostal regions of DiE and DiN. We conclude that unilateral hyperinflation impairs the mechanical efficiency of the apposing hemidiaphragm as a pressure generator.

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Selected References

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  1. Brooke M. H., Williamson E., Kaiser K. K. The behavior of four fiber types in developing and reinnervated muscle. Arch Neurol. 1971 Oct;25(4):360–366. doi: 10.1001/archneur.1971.00490040086010. [DOI] [PubMed] [Google Scholar]
  2. Close R. I. Dynamic properties of mammalian skeletal muscles. Physiol Rev. 1972 Jan;52(1):129–197. doi: 10.1152/physrev.1972.52.1.129. [DOI] [PubMed] [Google Scholar]
  3. Decramer M., De Troyer A., Kelly S., Zocchi L., Macklem P. T. Regional differences in abdominal pressure swings in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1984 Dec;57(6):1682–1687. doi: 10.1152/jappl.1984.57.6.1682. [DOI] [PubMed] [Google Scholar]
  4. Farkas G. A., Roussos C. Adaptability of the hamster diaphragm to exercise and/or emphysema. J Appl Physiol Respir Environ Exerc Physiol. 1982 Nov;53(5):1263–1272. doi: 10.1152/jappl.1982.53.5.1263. [DOI] [PubMed] [Google Scholar]
  5. Hubmayr R. D., Sprung J., Nelson S. Determinants of transdiaphragmatic pressure in dogs. J Appl Physiol (1985) 1990 Dec;69(6):2050–2056. doi: 10.1152/jappl.1990.69.6.2050. [DOI] [PubMed] [Google Scholar]
  6. Joyce G. C., Rack P. M., Westbury D. R. The mechanical properties of cat soleus muscle during controlled lengthening and shortening movements. J Physiol. 1969 Oct;204(2):461–474. doi: 10.1113/jphysiol.1969.sp008924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kelsen S. G., Wolanski T., Supinski G. S., Roessmann U. The effect of elastase-induced emphysema on diaphragmatic muscle structure in hamsters. Am Rev Respir Dis. 1983 Mar;127(3):330–334. doi: 10.1164/arrd.1983.127.3.330. [DOI] [PubMed] [Google Scholar]
  8. Lewis M. I., Zhan W. Z., Sieck G. C. Adaptations of the diaphragm in emphysema. J Appl Physiol (1985) 1992 Mar;72(3):934–943. doi: 10.1152/jappl.1992.72.3.934. [DOI] [PubMed] [Google Scholar]
  9. Mardini I. A., McCarter R. J. Contractile properties of the shortening rat diaphragm in vitro. J Appl Physiol (1985) 1987 Mar;62(3):1111–1116. doi: 10.1152/jappl.1987.62.3.1111. [DOI] [PubMed] [Google Scholar]
  10. Margulies S. S., Farkas G. A., Rodarte J. R. Effects of body position and lung volume on in situ operating length of canine diaphragm. J Appl Physiol (1985) 1990 Nov;69(5):1702–1708. doi: 10.1152/jappl.1990.69.5.1702. [DOI] [PubMed] [Google Scholar]
  11. Margulies S. S., Schriner R. W., Schroeder M. A., Hubmayr R. D. Static lung-lung interactions in unilateral emphysema. J Appl Physiol (1985) 1992 Aug;73(2):545–551. doi: 10.1152/jappl.1992.73.2.545. [DOI] [PubMed] [Google Scholar]
  12. Newman S., Road J., Bellemare F., Clozel J. P., Lavigne C. M., Grassino A. Respiratory muscle length measured by sonomicrometry. J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):753–764. doi: 10.1152/jappl.1984.56.3.753. [DOI] [PubMed] [Google Scholar]
  13. Sieck G. C., Cheung T. S., Blanco C. E. Diaphragm capillarity and oxidative capacity during postnatal development. J Appl Physiol (1985) 1991 Jan;70(1):103–111. doi: 10.1152/jappl.1991.70.1.103. [DOI] [PubMed] [Google Scholar]
  14. Sieck G. C., Sacks R. D., Blanco C. E. Absence of regional differences in the size and oxidative capacity of diaphragm muscle fibers. J Appl Physiol (1985) 1987 Sep;63(3):1076–1082. doi: 10.1152/jappl.1987.63.3.1076. [DOI] [PubMed] [Google Scholar]
  15. Sieck G. C., Sacks R. D., Blanco C. E., Edgerton V. R. SDH activity and cross-sectional area of muscle fibers in cat diaphragm. J Appl Physiol (1985) 1986 Apr;60(4):1284–1292. doi: 10.1152/jappl.1986.60.4.1284. [DOI] [PubMed] [Google Scholar]
  16. Sprung J., Deschamps C., Hubmayr R. D., Walters B. J., Rodarte J. R. In vivo regional diaphragm function in dogs. J Appl Physiol (1985) 1989 Aug;67(2):655–662. doi: 10.1152/jappl.1989.67.2.655. [DOI] [PubMed] [Google Scholar]
  17. Sprung J., Deschamps C., Margulies S. S., Hubmayr R. D., Rodarte J. R. Effect of body position on regional diaphragm function in dogs. J Appl Physiol (1985) 1990 Dec;69(6):2296–2302. doi: 10.1152/jappl.1990.69.6.2296. [DOI] [PubMed] [Google Scholar]
  18. Takaro T., White S. M. Unilateral severe experimental pulmonary emphysema. Am Rev Respir Dis. 1973 Aug;108(2):334–342. doi: 10.1164/arrd.1973.108.2.334. [DOI] [PubMed] [Google Scholar]

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