Correspondence (letter to the editor): Question Mark Over Hypocomplementemia

Unfortunately it remains unclear whether the intention was to describe an independent pathology (hypocomplementemic urticarial vasculitis syndrome) or whether the scenario was one of immunovasculitis (leukocytoclastic vasculitis) with a particularly pronounced reduction of complement factors. It would be interesting to know whether hypocomplementemia exists in such patients before disease onset or for a long period of time after symptoms have disappeared. Further, it is well known that diverse medications are the most common cause of immunovasculitis, which is always accomxpanied by a reduction in complement factors. No mention was made in the case report about drug or topical treatment preceding (or during) the illness.