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Socially-isolated rats fail to exhibit handling-induced increases in cannabinoid receptor density exhibited by their group-reared counterparts in the (a) caudal caudate putamen and (b) anterior thalamic nuclei. Data are mean ± S.E.M. ++P < 0.01, +P < 0.05 vs. Group Reared/Handled (ANOVA). Representative photomicrographs are shown in Fig. 4–5. aTN, anterior thalamic nuclei; cCPu, caudal caudate putamen.
