Overview: The neuropeptide BW receptor 1 (NPBW1, provisional nomenclature) is activated by two 23-amino-acid peptides, neuropeptide W (NPW-23) and neuropeptide B (NPB-23) (Shimomura et al., 2002; Fujii et al., 2002). C-terminally extended forms of the peptides (NPW-30 and NPB-29) also activate NPBW1 (Brezillon et al., 2003). Unique to both forms of NPB is the N-terminal bromination of the first tryptophan residue. des-Br-NPB-23 and des-Br-NPB-29 were not found to be major components of bovine hypothalamic tissue extracts. The NPBW2 receptor is activated by the short and C-terminal extended forms of NPB and NPW (Brezillon et al., 2003).
| Nomenclature | NPBW1 | NPBW2 |
| Other names | GPR7 | GPR8 |
| Ensembl ID | ENSG00000183729 | ENSG00000125522 |
| Principal transduction | Gi/0 (Mazzocchi et al., 2005) | Gi/0 (Mazzocchi et al., 2005) |
| Rank order of potency | NPB-29 > NPB-23 > NPW-23 > NPW-30 (Brezillon et al., 2003) | NPW-23 > NPW-30 > NPB-29 > NPB-23 (Brezillon et al., 2003) |
| Selective agonists | Ava-3, Ava-5 (Kanesaka et al., 2007) | – |
| Probes | >[125I]-NPW-23 (0.44 nM, Singh et al., 2004) | [125I]-NPW-23 |
Potency measurements were conducted with heterologously expressed receptors with a range of 0.14–0.57 nM (NPBW1) and 0.98–21 nM (NPBW2).
Glossary
Abbreviations:
- Ava3
TrpTyrLysAvaAvaAvaGlyArgAlaAlaGlyLeuLeuSerGlyLeu-NH2
- Ava5
TrpTyrLysAvaAvaAvaAvaAvaAvaGlyArgAlaAlaGlyLeuLeuSerGlyLeu-NH2
Further Reading
Lee DK, George SR, O'Dowd BF (2003). Continued discovery of ligands for G protein-coupled receptors. Life Sci74: 293–297.
Singh G, Davenport AP (2006). Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system. Br J Pharmacol148: 1033–1041.
References
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