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. 1993 Dec;92(6):2872–2876. doi: 10.1172/JCI116908

Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes.

Y D Halvorsen 1, S E Bursell 1, W O Wilkison 1, A C Clermont 1, M Brittis 1, T J McGovern 1, B M Spiegelman 1
PMCID: PMC288489  PMID: 8254042

Abstract

1-Butyryl-glycerol (monobutyrin) is a simple lipid product of adipocytes with angiogenic activity. Recent studies have shown that the biosynthesis of this compound is tightly linked to lipolysis, a process associated with changes in blood flow. We now present data indicating that monobutyrin is an effective vasodilator of rodent blood vessels using a fluorescent retinal angiogram assay. The vasodilatory activity of monobutyrin is potent (ED50 = 3.3 x 10(-7) M), dose dependent, and stereospecific. Because diabetes represents a catabolic, lipolytic state with numerous vascular complications, we examined the action and regulation of monobutyrin in insulin-deficient diabetic rats. Serum levels of monobutyrin in streptozotocin-induced diabetic rats were greatly elevated compared to normal animals. At the same time, the retinal vessels of the diabetic animals develop a resistance to the vasodilatory activity of monobutyrin. These results demonstrate a role for monobutyrin in the control of vascular tone and suggest a possible involvement in the pathology of diabetes.

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Selected References

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