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. Author manuscript; available in PMC: 2011 Jul 28.
Published in final edited form as: Neuroscience. 2009 Sep 15;168(4):971–981. doi: 10.1016/j.neuroscience.2009.09.020

Figure 2.

Figure 2

Functional regulation of AQP4 by PKC. Mean cell volume was measured for 3 min in AQP4-D54 cells (A; untreated n=7, Chel n=6, PMA n=4) and S180 mutant AQP4 (B; n=6). Cells were treated with either chelerythrine or PMA for 45 min before being given a 50% hyposmotic challenge. Representative graphs show water permeability over the first few seconds following hyposmotic challenge. Reciprocal exponential time constant (τ−1) is proportional to osmotic water permeability (C). AQP4+Chel are gliomas expressing WT AQP4 that were treated with chelrythrine. (Significance was assessed using an ANOVA *p<0.05 as compared to control.)