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. 1980 Jan;33(1):539–542. doi: 10.1128/jvi.33.1.539-542.1980

Phosphonoacetic Acid Inhibition of Frog Virus 3 Replication

R M Elliott 1,†, A Bateson 1, D C Kelly 1
PMCID: PMC288569  PMID: 16789189

Abstract

Phosphonoacetic acid at concentrations above 200 μg/ml inhibited the replication of frog virus 3 in BHK cells. The inhibition of viral DNA replication observed in these cells was reversible and correlated with the inhibition of the virus-induced DNA polymerase activity in an in vitro assay. The synthesis of frog virus 3-induced late or γ polypeptides was also inhibited by phosphonoacetic acid, although the early (α and β) polypeptides were unaffected.

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Selected References

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