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. 1980 Jan;33(1):543–546. doi: 10.1128/jvi.33.1.543-546.1980

Inhibition of herpes simplex virus type 2-induced biochemical transformation by interferon.

F Rapp, Y Nishiyama
PMCID: PMC288570  PMID: 6154151

Abstract

The effect of interferon on the biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus type 2 has been studied. Transformation was much less sensitive to the action of interferon than virus multiplication. However, the continuous presence of a high dose of interferon (2,000 U) inhibited transformation almost completely. Although we could not differentiate between the effect of interferon on fixation and expression of the virus thymidine kinase gene, data suggest that the inhibitory effect of interferon on transformation might be partially due to the suppression of virus thymidine kinase expression.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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