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. 1980 Jan;33(1):561–566. doi: 10.1128/jvi.33.1.561-566.1980

Immunological relationships of OMC-1, an endogenous virus of owl monkeys, with mammalian and avian type C viruses.

M Barbacid, M D Daniel, S A Aaronson
PMCID: PMC288575  PMID: 6154152

Abstract

The relationships between OMC-1, an endogenous oncovirus of owl monkey, and representatives of the three oncoviral genera have been investigated by radioimmunological techniques. The major structural protein of OMC-1 was shown to share antigenic determinants with the corresponding proteins of certain type C viruses of rodent, feline, and cervine origin. It was not possible to demonstrate antigenic cross-reactivity between OMC-1 and endogenous type C viruses of baboons. These findings argue that OMC-1 and baboon endogenous viruses do not represent direct descendants of an ancestor virus that became integrated within primates prior to the divergence of New and Old World species. A close antigenic relationship was established between the major structural proteins of OMC-1, an endogenous virus of deer (deer kidney virus), and avian reticuloendotheliosis viruses. These findings establish OMC-1 and deer kidney virus in the evolutionary lineage that may have led to the generation of avian reticuloendotheliosis virus, a group of oncogenic viruses capable of crossing the interclass barrier between mammals and birds.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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