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. 1980 Apr;34(1):285–287. doi: 10.1128/jvi.34.1.285-287.1980

Genetic variation during lytic reovirus infection: high-passage stocks of wild-type reovirus contain temperature-sensitive mutants.

R Ahmed, P R Chakraborty, B N Fields
PMCID: PMC288697  PMID: 7373710

Abstract

Wild-type clones of reovirus serotypes 1 (Lang), 2 (Jones), and 3 (Dearing) were serially passaged in L cells at a high multiplicity of infection, and the virus population was examined at passage levels 2, 5, and 11 for the presence of temperature-sensitive (ts) mutants. By passage 11 all three serotypes contained ts mutants that were not present in the original wild-type stock. ts mutants representing three mutant groups were identified. The majority of these mutants were in group G. Our results show that high-passage stocks of reovirus consist of a genetically heterogeneous population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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