Table 7.
The effexts of pre-existing stereocenters in the intramolecular Stetter reaction (substrates are racemates). 
|
|
trans:cis | |
| R = Me l51 98% ee | R = Me l53 94% ee | 50:50 | Yield = 97% |
| R = Ph 152 98% ee | R = Ph 154 96% ee | 50:50 | Yield = 96% |
|
|
||
| R = Me 155 90% ee | R = Me 157 95% ee | 50:50 | Yield = 90% |
| R = iPr 156 84% ee | R = Ph 158 96% ee | 50:50 | Yield = 95% |
| aR = iPr 156 94% ee | aR = Ph 158 98% ee | a50:50 | Yield = 95% |
|
|
||
| R = Bn 159 <5% ee | R = Bn 161 <5% ee | 15:85 | Yield = 95% |
| aR = Cy 160 20% ee | aR = Cy l62 6% ee | a3.5:96.5 | Yield = 74% |
a
20 mol% catalyst 40 was used.