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. 1980 Sep;35(3):962–964. doi: 10.1128/jvi.35.3.962-964.1980

Equine connective tissue tumors contain unintegrated bovine papilloma virus DNA.

E Amtmann, H Müller, G Sauer
PMCID: PMC288890  PMID: 6252350

Abstract

Bovine papilloma virus (BPV) appears to be the etiological agent of common equine connective tissue tumors. We investigated the physical state of the viral DNA within such tumors and found no indication for integration into the host genome. The BPV genomes were present as free circular episomes. Two equine sarcoids were shown to contain multiple copies of free circular BPV type 1 (BPV-1) DNA. When the tumors were digested with several single-cut restriction enzymes, there were only form III BPV-1 DNA sequences could be revealed. One of the sarcoids contained, apart from wild-type BPV-1 DNA, a class of smaller BPV-1 circular DNA molecules bearing a deletion of approximately 9% of the BPV-1 genome. This deletion is located in the physical map between the relative units 0 and 0.32.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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