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. 1986 Nov;60(2):431–435. doi: 10.1128/jvi.60.2.431-435.1986

Prevention of simian acquired immune deficiency syndrome with a formalin-inactivated type D retrovirus vaccine.

P A Marx, N C Pedersen, N W Lerche, K G Osborn, L J Lowenstine, A A Lackner, D H Maul, H S Kwang, J D Kluge, C P Zaiss, et al.
PMCID: PMC288910  PMID: 3021978

Abstract

Experimental induction of simian acquired immune deficiency syndrome (SAIDS) by inoculation of juvenile rhesus monkeys with a type D retrovirus was prevented by immunization with Formalin-killed whole SAIDS retrovirus serotype 1 containing the adjuvant threonyl muramyl-dipeptide. All six immunized animals developed neutralizing antibody after three injections, while six age-matched cagemates receiving adjuvant alone were antibody free. All 12 monkeys were challenged intravenously with a potentially lethal dose of SAIDS retrovirus serotype 1. The six immunized animals failed to develop persistent viremia and remained clinically normal 8 months postchallenge. In contrast, five of six nonvaccinates developed persistent viremia, four of six developed clinical SAIDS, and two of six died with SAIDS at 10 weeks and 8 months postchallenge, respectively. These results show that prevention of a common spontaneous retrovirus-induced immunosuppressive disease in macaques is now possible by vaccination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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