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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Neuropharmacology. 2009 Sep 9;58(2):457–464. doi: 10.1016/j.neuropharm.2009.09.004

Figure 1.

Figure 1

Single unit extracellular recordings in rat dorsal raphe nucleus slices from unstressed rats and from rats submitted to 15 min of forced swim (stressed rats). Concentration-response curve to Nociceptin/Orphanin FQ (N/OFQ), bath applied for 10 to 15 min. The spontaneous firing, facilitated by adding 10 μM phenylephrine, was sampled on-line in 10 s bins. No more than one neuron was recorded from each slice. Basal firing rate was 1.76 ± 0.16 Hz in dorsal raphe nucleus slices from unstressed rats (n=8) and 2.08 ± 0.22 Hz from stressed rats (n=8).