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. 1986 Nov;60(2):726–728. doi: 10.1128/jvi.60.2.726-728.1986

Reovirus type 1 is secreted into the bile.

D H Rubin, M A Eaton, T Costello
PMCID: PMC288947  PMID: 3022004

Abstract

Reovirus type 1, known to be a cause of systemic and intestinal disease in mice, is secreted into the bile of adult A/J mice after viremia. Virus found in the bile in concentrations higher than those in blood may indicate that reovirus type 1 is actively transported into the bile. The transport of virus was independent of levels of virus-specific immunoglobulin A antibody. Modifications of the virus that occurred during transport did not discernibly affect the infectivity of the virus. Entry of virus into the bile may be an important mechanism by which an enteric virus that produces systemic disease reenters the intestine for transmission.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blitzer B. L., Boyer J. L. Cellular mechanisms of bile formation. Gastroenterology. 1982 Feb;82(2):346–357. [PubMed] [Google Scholar]
  2. Brown T. A., Russell M. W., Mestecky J. Elimination of intestinally absorbed antigen into the bile by IgA. J Immunol. 1984 Feb;132(2):780–782. [PubMed] [Google Scholar]
  3. Co M. S., Gaulton G. N., Tominaga A., Homcy C. J., Fields B. N., Greene M. I. Structural similarities between the mammalian beta-adrenergic and reovirus type 3 receptors. Proc Natl Acad Sci U S A. 1985 Aug;82(16):5315–5318. doi: 10.1073/pnas.82.16.5315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Joklik W. K. Studies on the effect of chymotrypsin on reovirions. Virology. 1972 Sep;49(3):700–715. doi: 10.1016/0042-6822(72)90527-2. [DOI] [PubMed] [Google Scholar]
  5. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  6. MIMS C. A. Rift Valley fever virus in mice. VI. Histological changes in the liver in relation to virus multiplication. Aust J Exp Biol Med Sci. 1957 Dec;35(6):595–604. doi: 10.1038/icb.1957.61. [DOI] [PubMed] [Google Scholar]
  7. MIMS C. A. The response of mice to large intravenous injections of ectromelia virus. I. The fate of injected virus. Br J Exp Pathol. 1959 Dec;40:533–542. [PMC free article] [PubMed] [Google Scholar]
  8. Papadimitriou J. M. Electron micrographic features of acute murine reovirus hepatitis. Am J Pathol. 1965 Oct;47(4):565–585. [PMC free article] [PubMed] [Google Scholar]
  9. Papadimitriou J. M. The biliary tract in acute murine reovirus 3 infection. Light and electron microscopic study. Am J Pathol. 1968 Mar;52(3):595–611. [PMC free article] [PubMed] [Google Scholar]
  10. Peppard J., Orlans E., Payne A. W., Andrew E. The elimination of circulating complexes containing polymeric IgA by excretion in the bile. Immunology. 1981 Jan;42(1):83–89. [PMC free article] [PubMed] [Google Scholar]
  11. Ramig R. F., Cross R. K., Fields B. N. Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3. J Virol. 1977 Jun;22(3):726–733. doi: 10.1128/jvi.22.3.726-733.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Renston R. H., Jones A. L., Christiansen W. D., Hradek G. T., Underdown B. J. Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A. Science. 1980 Jun 13;208(4449):1276–1278. doi: 10.1126/science.7375938. [DOI] [PubMed] [Google Scholar]
  13. Reuben A. Bile formation: sites and mechanisms. Hepatology. 1984 Sep-Oct;4(5 Suppl):15S–24S. doi: 10.1002/hep.1840040804. [DOI] [PubMed] [Google Scholar]
  14. Rubin D. H., Eaton M. A., Anderson A. O. Reovirus infection in adult mice: the virus hemagglutinin determines the site of intestinal disease. Microb Pathog. 1986 Feb;1(1):79–87. doi: 10.1016/0882-4010(86)90034-3. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rubin D. H., Kornstein M. J., Anderson A. O. Reovirus serotype 1 intestinal infection: a novel replicative cycle with ileal disease. J Virol. 1985 Feb;53(2):391–398. doi: 10.1128/jvi.53.2.391-398.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Smith R. E., Zweerink H. J., Joklik W. K. Polypeptide components of virions, top component and cores of reovirus type 3. Virology. 1969 Dec;39(4):791–810. doi: 10.1016/0042-6822(69)90017-8. [DOI] [PubMed] [Google Scholar]
  17. Wolf J. L., Kauffman R. S., Finberg R., Dambrauskas R., Fields B. N., Trier J. S. Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine. Gastroenterology. 1983 Aug;85(2):291–300. [PubMed] [Google Scholar]
  18. Wolf J. L., Rubin D. H., Finberg R., Kauffman R. S., Sharpe A. H., Trier J. S., Fields B. N. Intestinal M cells: a pathway for entry of reovirus into the host. Science. 1981 Apr 24;212(4493):471–472. doi: 10.1126/science.6259737. [DOI] [PubMed] [Google Scholar]

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