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. 1986 Nov;60(2):754–760. doi: 10.1128/jvi.60.2.754-760.1986

Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity.

E Terwilliger, J G Sodroski, C A Rosen, W A Haseltine
PMCID: PMC288951  PMID: 3490583

Abstract

Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.

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Selected References

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