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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: AIDS. 2009 Nov 27;23(18):2459–2466. doi: 10.1097/QAD.0b013e328331f702

Table 1.

Classification of infant HIV infection comparing DBS HIV-1 RNA results with HIV-1 plasma RNA results at the threshold of ≥1,000 copies/mL (panel a) and ≥10,000 copies/mL (panel b) and comparing DBS HIV-1 RNA results with DBS HIV-1 DNA results at the threshold of ≥1,000 copies/mL (panel c) and ≥10,000 copies/mL (panel d), Tanzania, 2008-9

a Plasma RNA b Plasma RNA
≥1,000 <1,000 total ≥10,000 <10,000 total


≥1,000 34 1 35 ≥10,000 31 0 31
DBS RNA <1,000 0 141 141 DBS RNA <10,000 0 145 145
total 34 142 176 total 31 145 176
SN 1.00 (0.90, 1.00), SP 0.99 (0.96, 1.00)
PPV 0.97, NPV 1.00
SN 1.00 (0.89, 1.00), SP 1.00 (0.97, 1.00)
PPV 1.00, NPV, 1.00
c DBS DNA d DBS DNA
Positive Negative total Positive Negative total


≥1,000 35 0 35 ≥10,000 31 0 31
DBS RNA <1,000 1 140 141 DBS RNA <10,000 5 140 145
total 36 140 176 total 36 140 176
SN 0.97 (0.86, 1.00), SP 1.00 (0.97, 1.00)
PPV 1.00, NPV 0.99
SN 0.86 (0.71, 0.94), SP 1.00 (0.97, 1.00)
PPV 1.00, NPV 0.97

SN = sensitivity

SP = specificity

PPV = positive predictive value

NPV = negative predictive value

95% confidence intervals are shown in brackets