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. 1992 Apr;66(4):2523–2526. doi: 10.1128/jvi.66.4.2523-2526.1992

A chimeric poliovirus/CD4 receptor confers susceptibility to poliovirus on mouse cells.

H C Selinka 1, A Zibert 1, E Wimmer 1
PMCID: PMC289051  PMID: 1312641

Abstract

The human poliovirus receptor consists of three extracellular immunoglobulinlike domains, a transmembrane domain, and an intracytoplasmic domain. The amino-terminal variable-type domain (V domain) of the human poliovirus receptor is necessary and sufficient for its function as a viral receptor (H.-C. Selinka, A. Zibert, and E. Wimmer, Proc. Natl. Acad. Sci. USA 88:3598-3602, 1991). In this paper, data are presented showing that transfer of the putative poliovirus receptor-binding domain to a truncated receptor for the human immunodeficiency virus results in a functional receptor for poliovirus. After expression in mouse cells, this chimeric protein confers susceptibility to poliovirus. Thus, unlike human immunodeficiency virus, poliovirus can enter mouse cells by way of a truncated CD4 receptor if the specific binding domain for poliovirus is provided.

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Selected References

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