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. 1992 Sep;66(9):5305–5312. doi: 10.1128/jvi.66.9.5305-5312.1992

Identification of Aleutian mink disease parvovirus transcripts in macrophages of infected adult mink.

H Kanno 1, J B Wolfinbarger 1, M E Bloom 1
PMCID: PMC289085  PMID: 1323697

Abstract

We examined Aleutian mink disease parvovirus (ADV) mRNA expression in lymph nodes of adult mink infected with ADV by Northern (RNA) blot and in situ hybridization. In Northern blot analysis, ADV transcripts were detected in the poly(A) RNA fraction extracted from mesenteric lymph nodes of two of five mink 10 days after intraperitoneal inoculation with the virulent Utah I strain of ADV. In strand-specific in situ hybridization, ADV DNA and mRNA were detected in some macrophagelike cells located in the medullary sinus in mesenteric lymph node sections from two of six infected mink by using biotinylated probes. In suspensions of lymph node cells, about 30% of the cells phagocytic for latex particles contained ADV DNA and about 1% of these cells contained ADV mRNA. In peritoneal exudate cells, about 20% of the macrophagelike cells contained ADV DNA and about 2% of these cells contained ADV mRNA. These results indicated that some macrophages in ADV-infected mink contained ADV mRNA and were target cells in ADV infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aasted B., Bloom M. E. Sensitive radioimmune assay for measuring Aleutian disease virus antigen and antibody. J Clin Microbiol. 1983 Sep;18(3):637–644. doi: 10.1128/jcm.18.3.637-644.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aasted B., Tierney G. S., Bloom M. E. Analysis of the quantity of antiviral antibodies from mink infected with different Aleutian disease virus strains. Scand J Immunol. 1984 May;19(5):395–402. doi: 10.1111/j.1365-3083.1984.tb00947.x. [DOI] [PubMed] [Google Scholar]
  3. Alexandersen S., Bloom M. E., Perryman S. Detailed transcription map of Aleutian mink disease parvovirus. J Virol. 1988 Oct;62(10):3684–3694. doi: 10.1128/jvi.62.10.3684-3694.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Alexandersen S., Bloom M. E., Wolfinbarger J. Evidence of restricted viral replication in adult mink infected with Aleutian disease of mink parvovirus. J Virol. 1988 May;62(5):1495–1507. doi: 10.1128/jvi.62.5.1495-1507.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Alexandersen S., Bloom M. E., Wolfinbarger J., Race R. E. In situ molecular hybridization for detection of Aleutian mink disease parvovirus DNA by using strand-specific probes: identification of target cells for viral replication in cell cultures and in mink kits with virus-induced interstitial pneumonia. J Virol. 1987 Aug;61(8):2407–2419. doi: 10.1128/jvi.61.8.2407-2419.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bloom M. E., Alexandersen S., Mori S., Wolfinbarger J. B. Analysis of parvovirus infections using strand-specific hybridization probes. Virus Res. 1989 Sep;14(1):1–25. doi: 10.1016/0168-1702(89)90066-x. [DOI] [PubMed] [Google Scholar]
  7. Bloom M. E., Race R. E., Aasted B., Wolfinbarger J. B. Analysis of Aleutian disease virus infection in vitro and in vivo: demonstration of Aleutian disease virus DNA in tissues of infected mink. J Virol. 1985 Sep;55(3):696–703. doi: 10.1128/jvi.55.3.696-703.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bloom M. E., Race R. E., Hadlow W. J., Chesebro B. Aleutian disease of mink: the antibody response of sapphire and pastel mink to Aleutian disease virus. J Immunol. 1975 Oct;115(4):1034–1037. [PubMed] [Google Scholar]
  9. Bloom M. E., Race R. E., Wolfinbarger J. B. Analysis of Aleutian disease of mink parvovirus infection using strand-specific hybridization probes. Intervirology. 1987;27(2):102–111. doi: 10.1159/000149727. [DOI] [PubMed] [Google Scholar]
  10. Bloom M. E., Race R. E., Wolfinbarger J. B. Characterization of Aleutian disease virus as a parvovirus. J Virol. 1980 Sep;35(3):836–843. doi: 10.1128/jvi.35.3.836-843.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cafruny W. A., Plagemann P. G. Immune response to lactate dehydrogenase-elevating virus: serologically specific rabbit neutralizing antibody to the virus. Infect Immun. 1982 Sep;37(3):1007–1012. doi: 10.1128/iai.37.3.1007-1012.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Cheema A., Henson J. B., Gorham J. R. Aleutian disease of mink. Prevention of lesions by immunosuppression. Am J Pathol. 1972 Mar;66(3):543–556. [PMC free article] [PubMed] [Google Scholar]
  13. Chesebro B., Bloom M., Hadlow W., Race R. Purification and ultrastructure of Aleutian disease virus of mink. Nature. 1975 Apr 3;254(5499):456–457. doi: 10.1038/254456a0. [DOI] [PubMed] [Google Scholar]
  14. Cotmore S. F., Tattersall P. The autonomously replicating parvoviruses of vertebrates. Adv Virus Res. 1987;33:91–174. doi: 10.1016/s0065-3527(08)60317-6. [DOI] [PubMed] [Google Scholar]
  15. Crandell R. A., Fabricant C. G., Nelson-Rees W. A. Development, characterization, and viral susceptibility of a feline (Felis catus) renal cell line (CRFK). In Vitro. 1973 Nov-Dec;9(3):176–185. doi: 10.1007/BF02618435. [DOI] [PubMed] [Google Scholar]
  16. Eklund C. M., Hadlow W. J., Kennedy R. C., Boyle C. C., Jackson T. A. Aleutian disease of mink: properties of the etiologic agent and the host responses. J Infect Dis. 1968 Dec;118(5):510–526. doi: 10.1093/infdis/118.5.510. [DOI] [PubMed] [Google Scholar]
  17. Hahn E. C., Hahn P. S. Autoimmunity in Aleutian disease: contribution of antiviral and anti-DNA antibody to hypergammaglobulinemia. Infect Immun. 1983 Aug;41(2):494–500. doi: 10.1128/iai.41.2.494-500.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Hahn E. C., Kenyon A. J. Anti-deoxyribonucleic acid antibody associated with persistent infection of mink with Aleutian disease virus. Infect Immun. 1980 Aug;29(2):452–458. doi: 10.1128/iai.29.2.452-458.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Halstead S. B., O'Rourke E. J. Dengue viruses and mononuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med. 1977 Jul 1;146(1):201–217. doi: 10.1084/jem.146.1.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. LEADER R. W., WAGNER B. M., HENSON J. B., GORHAM J. R. Structural and histochemical observations of liver and kidney in Aleutian disease of mink. Am J Pathol. 1963 Jul;43:33–53. [PMC free article] [PubMed] [Google Scholar]
  21. Lawrence J. B., Singer R. H. Quantitative analysis of in situ hybridization methods for the detection of actin gene expression. Nucleic Acids Res. 1985 Mar 11;13(5):1777–1799. doi: 10.1093/nar/13.5.1777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Mori S., Wolfinbarger J. B., Miyazawa M., Bloom M. E. Replication of Aleutian mink disease parvovirus in lymphoid tissues of adult mink: involvement of follicular dendritic cells and macrophages. J Virol. 1991 Feb;65(2):952–956. doi: 10.1128/jvi.65.2.952-956.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. PORTER D. D., DIXON F. J., LARSEN A. E. METABOLISM AND FUNCTION OF GAMMA GLOBULIN IN ALEUTIAN DISEASE OF MINK. J Exp Med. 1965 Jun 1;121:889–900. doi: 10.1084/jem.121.6.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Parwaresch M. R., Wacker H. H. Origin and kinetics of resident tissue macrophages. Parabiosis studies with radiolabelled leucocytes. Cell Tissue Kinet. 1984 Jan;17(1):25–39. doi: 10.1111/j.1365-2184.1984.tb00565.x. [DOI] [PubMed] [Google Scholar]
  25. Porter D. D., Larsen A. E., Cox N. A., Porter H. G., Suffin S. C. Isolation of Aleutian disease virus of mink in cell culture. Intervirology. 1977;8(3):129–144. doi: 10.1159/000148888. [DOI] [PubMed] [Google Scholar]
  26. Porter D. D., Larsen A. E., Porter H. G. Aleutian disease of mink. Adv Immunol. 1980;29:261–286. doi: 10.1016/s0065-2776(08)60046-2. [DOI] [PubMed] [Google Scholar]
  27. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. 3. Immune complex arteritis. Am J Pathol. 1973 May;71(2):331–344. [PMC free article] [PubMed] [Google Scholar]
  28. Porter D. D., Larsen A. E., Porter H. G. The pathogenesis of Aleutian disease of mink. I. In vivo viral replication and the host antibody response to viral antigen. J Exp Med. 1969 Sep 1;130(3):575–593. doi: 10.1084/jem.130.3.575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Porter D. D., Porter H. G., Larsen A. E. Much of the increased IgG in Aleutian disease of mink is viral antibody. J Exp Pathol. 1984;1(2):79–88. [PubMed] [Google Scholar]
  30. Porterfield J. S. Antibody-dependent enhancement of viral infectivity. Adv Virus Res. 1986;31:335–355. doi: 10.1016/s0065-3527(08)60268-7. [DOI] [PubMed] [Google Scholar]
  31. Race R. E., Chesebro B., Bloom M. E., Aasted B., Wolfinbarger J. Monoclonal antibodies against Aleutian disease virus distinguish virus strains and differentiate sites of virus replication from sites of viral antigen sequestration. J Virol. 1986 Jan;57(1):285–293. doi: 10.1128/jvi.57.1.285-293.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Sawyer R. T., Strausbauch P. H., Volkman A. Resident macrophage proliferation in mice depleted of blood monocytes by strontium-89. Lab Invest. 1982 Feb;46(2):165–170. [PubMed] [Google Scholar]

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