Table 4.
Haemodynamic responses during exercise testing
| Baseline | Placebo | Allopurinol | p value* | |
|---|---|---|---|---|
| Heart rate (beats per min) | ||||
| Baseline | 62·3 (10·3) | 61·3 (9·2) | 63·8 (8·6) | 0·025 |
| Stage 1 | 95·2 (13·7) | 94·3 (13·3) | 95·6 (13·5) | 0·154 |
| Peak exercise | 113·6 (15·3) | 112·4 (15·6) | 118·5 (15·2) | 0·0006 |
| Systolic blood pressure (mm Hg) | ||||
| Baseline | 126·8 (16·6) | 124·3 (13·7) | 123·7 (16·2) | 0·755 |
| Stage 1 | 141·6 (21·0) | 140·0 (16·1) | 135·5 (19·3) | 0·042 |
| Peak exercise | 159·3 (22·6) | 155·1 (18·4) | 158·7 (22·4) | 0·116 |
| Diastolic blood pressure (mm Hg) | ||||
| Baseline | 72·8 (8·6) | 72·9 (7·7) | 72·2 (9·9) | 0·577 |
| Stage 1 | 72·9 (10·6) | 74·8 (8·6) | 71·7 (10·1) | 0·008 |
| Peak exercise | 76·1 (12·7) | 78·5 (10·2) | 75·4 (11·9) | 0·015 |
| Rate pressure product (beats per min×mm Hg) | ||||
| Baseline | 7897 (1709) | 7607 (1471) | 7910 (1577) | 0·123 |
| Stage 1 | 13 349 (2997) | 13 114 (2617) | 12 756 (2798) | 0·174 |
| Peak exercise | 18 210 (4104) | 17 484 (3655) | 18 842 (3791) | 0·001 |
Data are mean (SD).
*
For difference between allopurinol and placebo.