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. 1992 Sep;66(9):5598–5602. doi: 10.1128/jvi.66.9.5598-5602.1992

Multimerization of ICP0, a herpes simplex virus immediate-early protein.

J Chen 1, C Panagiotidis 1, S Silverstein 1
PMCID: PMC289122  PMID: 1323713

Abstract

ICP0, a herpes simplex virus immediate-early gene product, is a highly phosphorylated nuclear protein that is a potent activator of virus and host genes. Using biochemical and genetic assays employing plasmids encoding mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we mutant forms of ICP0 and a recombinant adenovirus that expresses ICP0, we provide evidence that the protein multimerizes. Some mutant forms of ICP0 were transdominant and interfered with activation of a target reporter gene or with complementation of an ICP0-minus virus.

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Selected References

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