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. 1992 Sep;66(9):5677–5681. doi: 10.1128/jvi.66.9.5677-5681.1992

Epstein-Barr virus DNA recombines via latent origin of replication with the human genome in the lymphoblastoid cell line RGN1.

G Gualandi 1, E Santolini 1, E Calef 1
PMCID: PMC289137  PMID: 1323719

Abstract

We show here that in a lymphoblastoid cell line Epstein-Barr virus DNA recombines with the human genome. The genetic exchange involves the oriP region of the virus. A junction between viral and human DNA from this line has been cloned and sequenced. The results indicate that the integration of Epstein-Barr virus DNA involves a region of the human genome which contains internal short repetition. An 800-bp probe has been isolated from the human part of the junction. This probe has been used to show that the human region exists as a duplication in normal cells.

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Selected References

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