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. 1992 Sep;66(9):5691–5695. doi: 10.1128/jvi.66.9.5691-5695.1992

Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus.

Y Kubo 1, Y Nakagawa 1, K Kakimi 1, H Matsui 1, M Iwashiro 1, K Kuribayashi 1, T Masuda 1, H Hiai 1, T Hirama 1, S Yanagawa 1, et al.
PMCID: PMC289140  PMID: 1323720

Abstract

The Duplan strain of murine leukemia virus induces murine AIDS in C57BL/6 mice. When spleen cells from C57BL/6 mice infected with the virus were transplanted into nude mice, subcutaneous solid tumors at the transplanted sites were formed and splenomegaly and lymphadenopathy were induced. These transplantable cells were Thy-1- CD4+ alpha-beta T-cell receptor-positive T cells and integrated with the pathogenic defective viral genome. These results indicate that neoplastic cells of T-cell lineage were induced by infecting C57BL/6 mice with murine AIDS virus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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