Figure 1.

Cytoscape network representation (www.cytoscape.org) of the sequence relationships in cog0402 from the amidohydrolase superfamily. Each node in the network represents a single sequence and each edge (depicted as lines) represents the pairwise connection between two sequences with the most significant BLAST E-value (better than 1 × 10⁻⁷⁰). Lengths of edges are not meaningful except that sequences in tightly clustered groups are relatively more similar to each other than sequences with few connections. In subcluster 4 the green-colored nodes catalyze the deamination of 8-oxoguanine and possess a conserved Cys-Ser dyad C-terminal to β-strand 4. In subcluster 4 the blue-colored nodes possess a Thr-Thr dyad and catalyze the deamination of isoxanthopterin. In subcluster 4 the red-colored nodes have a Thr-Ser dyad. Additional information is presented in the text.