Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1963 May;42(5):661–669. doi: 10.1172/JCI104757

STUDIES ON LYSOSOMES. II. THE EFFECT OF CORTISONE ON THE RELEASE OF ACID HYDROLASES FROM A LARGE GRANULE FRACTION OF RABBIT LIVER INDUCED BY AN EXCESS OF VITAMIN A*

Gerald Weissmann 1,†, Lewis Thomas 1
PMCID: PMC289331  PMID: 13999782

Full text

PDF
661

Images in this article

665Image
on p.665

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARBER A. A., OTTOLENGHI A. Effect of ethylenediaminetetraacetate on lipide peroxide formation and succinoxidase inactivation by ultraviolet light. Proc Soc Exp Biol Med. 1957 Nov;96(2):471–473. doi: 10.3181/00379727-96-23510. [DOI] [PubMed] [Google Scholar]
  2. COHN Z. A., HIRSCH J. G. The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes. J Exp Med. 1960 Dec 1;112:983–1004. doi: 10.1084/jem.112.6.983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DE DUVE C., PRESSMAN B. C., GIANETTO R., WATTIAUX R., APPELMANS F. Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J. 1955 Aug;60(4):604–617. doi: 10.1042/bj0600604. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DE DUVE C., WATTIAUX R., WIBO M. Effects of fat-soluble compounds on lysosomes in vitro. Biochem Pharmacol. 1962 Aug;9:97–116. doi: 10.1016/0006-2952(62)90015-1. [DOI] [PubMed] [Google Scholar]
  5. DINGLE J. T., LUCY J. A., FELL H. B. Studies on the mode of action of excess of vitamin A. 1. Effect of excess of vitamin A on the metabolism and composition of embryonic chick-limb cartilage grown in organ culture. Biochem J. 1961 Jun;79:497–500. doi: 10.1042/bj0790497. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DINGLE J. T. Studies on the mode of action of excess of vitamin A. 3. Release of a bound protease by the action of vitamin A. Biochem J. 1961 Jun;79:509–512. doi: 10.1042/bj0790509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. DOWLING J. E., WALD G. The role of vitamin A acid. Vitam Horm. 1960;18:515–541. doi: 10.1016/s0083-6729(08)60878-x. [DOI] [PubMed] [Google Scholar]
  8. FELL H. B., DINGLE J. T., WEBB M. Studies on the mode of action of excess of vitamin A. 4. The specificity of the effect on embryonic chick-limb cartilage in culture and on isolated rat-liver lysosomes. Biochem J. 1962 Apr;83:63–69. doi: 10.1042/bj0830063. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FELL H. B., THOMAS L. Comparison of the effects of papain and vitamin A on cartilage. II. The effects on organ cultures of embryonic skeletal tissue. J Exp Med. 1960 May 1;111:719–744. doi: 10.1084/jem.111.5.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. FELL H. B., THOMAS L. The influence of hydrocortisone on the action of excess vitamin A on limb bone rudiments in culture. J Exp Med. 1961 Sep 1;114:343–362. doi: 10.1084/jem.114.3.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GERBER B. R., FRANKLIN E. C., SCHUBERT M. Ultracentrifugal fractionation of bovine nasal chondromucoprotein. J Biol Chem. 1960 Oct;235:2870–2875. [PubMed] [Google Scholar]
  12. JANOFF A., WEISSMANN G., ZWEIOFACH B. W., THOMAS L. Pathogenesis of experimental shock. IV. Studies on lysosomes in normal and tolerant animals subjected to lethal trauma and endotoxemia. J Exp Med. 1962 Oct 1;116:451–466. doi: 10.1084/jem.116.4.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. JARVINEN K. A. J. Effect of cortisone on reaction of skin to ultra-violet light. Br Med J. 1951 Dec 8;2(4744):1377–1378. doi: 10.1136/bmj.2.4744.1377. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LACK C. H. Chondrolvsis. Ann Phys Med. 1961 Aug;6:93–99. [PubMed] [Google Scholar]
  15. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  16. LUCY J. A., DINGLE J. T., FELL H. B. Studies on the mode of action of excess of vitamin A. 2. A possible role of intracellular proteases in the degradation of cartilage matrix. Biochem J. 1961 Jun;79:500–508. doi: 10.1042/bj0790500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. SHATTON J., SCHUBERT M. Isolation of a mucoprotein from cartilage. J Biol Chem. 1954 Dec;211(2):565–573. [PubMed] [Google Scholar]
  18. THOMAS L., McCLUSKEY R. T., LI J., WEISSMANN G. Prevention by cortisone of the changes in cartilage induced by an excess of vitamin A in rabbits. Am J Pathol. 1963 Mar;42:271–283. [PMC free article] [PubMed] [Google Scholar]
  19. THOMAS L., McCLUSKEY R. T., POTTER J. L., WEISSMANN G. Comparison of the effects of papain n vitamin A on cartilage. I. The effects in rabbits. J Exp Med. 1960 May 1;111:705–718. doi: 10.1084/jem.111.5.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. THOMAS L. Reversible collapse of rabbit ears after intravenous papain, and prevention of recovery by cortisone. J Exp Med. 1956 Aug 1;104(2):245–252. doi: 10.1084/jem.104.2.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. WEISSMANN G. Alterations in connective tissue and intestine produced by hypervitaminosis A in Xenopus laevis. Nature. 1961 Oct 21;192:235–236. doi: 10.1038/192235a0. [DOI] [PubMed] [Google Scholar]
  22. WEISSMANN G., DINGLE J. Release of lysosomal protease by ultraviolet irradiation and inhibition by hydrocortisone. Exp Cell Res. 1961 Oct;25:207–210. doi: 10.1016/0014-4827(61)90328-7. [DOI] [PubMed] [Google Scholar]
  23. WEISSMANN G., FELL H. B. The effect of hydrocortisone on the response of fetal rat skin in culture to ultraviolet irradiation. J Exp Med. 1962 Sep 1;116:365–380. doi: 10.1084/jem.116.3.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. WEISSMANN G., THOMAS L. Studies on lysosomes. I. The effects of endotoxin, endotoxin tolerance, and cortisone on the release of acid hydrolases from a granular fraction of rabbit liver. J Exp Med. 1962 Oct 1;116:433–450. doi: 10.1084/jem.116.4.433. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES