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The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1963 Aug;42(8):1286–1299. doi: 10.1172/JCI104813

THE PROTEIN-BINDING OF C14-BILIRUBIN IN HUMAN AND MURINE SERUM*

J Donald Ostrow 1,, Rudi Schmid 1
PMCID: PMC289399  PMID: 14060402

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLEN T. H., ORAHOVATS P. D. Combination of toluidine dye isomers with plasma albumin. Am J Physiol. 1950 Jun 1;161(3):473–482. doi: 10.1152/ajplegacy.1950.161.3.473. [DOI] [PubMed] [Google Scholar]
  2. ALLEN T. H., ORAHOVATS P. D. Kinetics of reaction between T-1824 and liver slice in mixtures of plasma albumin. Am J Physiol. 1951 Jan;164(1):123–130. doi: 10.1152/ajplegacy.1950.164.1.123. [DOI] [PubMed] [Google Scholar]
  3. BARAC G. [Interactions of bilirubin with plasma proteins, and the state of bilirubin in normal human plasma]. Arch Int Physiol. 1953 Apr;61(2):129–140. doi: 10.3109/13813455309147705. [DOI] [PubMed] [Google Scholar]
  4. BEEKEN W. L., VOLWILER W., GOLDSWORTHY P. D., GARBY L. E., REYNOLDS W. E., STOGSDILL R., STEMLER R. S. Studies of I-131-albumin catabolism and distribution in normal young male adults. J Clin Invest. 1962 Jun;41:1312–1333. doi: 10.1172/JCI104594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BRUCKNER J. A study on the estimation of low concentrations of serum bilirubin. Am J Clin Pathol. 1959 Dec;32:513–520. doi: 10.1093/ajcp/32.6.513. [DOI] [PubMed] [Google Scholar]
  6. BURNSTINE R. C., SCHMID R. Solubility of bilirubin in aqueous solutions. Proc Soc Exp Biol Med. 1962 Feb;109:356–358. doi: 10.3181/00379727-109-27201. [DOI] [PubMed] [Google Scholar]
  7. CARBONE J. V., GRODSKY G. M. Constitutional nonhemolytic hyperbilirubinemia in the rat: defect of bilirubin conjugation. Proc Soc Exp Biol Med. 1957 Mar;94(3):461–463. doi: 10.3181/00379727-94-22979. [DOI] [PubMed] [Google Scholar]
  8. COHEN S., GORDON A. H. Catabolism of plasma albumin by the perfused rat liver. Biochem J. 1958 Dec;70(4):544–551. doi: 10.1042/bj0700544. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. CRIGLER J. F., Jr, NAJJAR V. A. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics. 1952 Aug;10(2):169–180. [PubMed] [Google Scholar]
  10. DI LEO E. P., BUTTARO C. A., BIANCONI B. The electrophoretic pattern of serum bilirubin, ascitic and cerebrospinal fluids: a study of 232 cases of icterus. Panminerva Med. 1960 Jan;2:10–13. [PubMed] [Google Scholar]
  11. EARLE D. P., HUTT M. P., SCHMID K., GITLIN D. Observations on double albumin: a genetically transmitted serum protein anomaly. J Clin Invest. 1959 Aug;38(8):1412–1420. doi: 10.1172/JCI103917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. FOG J. Determination of bilirubin in serum as alkaline azobilirubin. Scand J Clin Lab Invest. 1958;10(3):241–245. doi: 10.1080/00365515809087173. [DOI] [PubMed] [Google Scholar]
  13. GERBRANDY J., van LEEUWEN A., HELLENDOORN H. B., de VARIES L. The binding between electrolytes and serum proteins calculated from an in vivo filtration method. Clin Sci. 1960 May;19:181–193. [PubMed] [Google Scholar]
  14. GITIL D., LANDING B. H., WHIPPLE A. The localization of homolgous plasma proteins in the tissues of young human beings as demonstrated with fluorescent antibodies. J Exp Med. 1953 Feb 1;97(2):163–176. doi: 10.1084/jem.97.2.163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. GOLDSWORTHY P. D., VOLWILER W. Comparative metabolic fate of chemically (I 131) and biosynthetically (C14-or S35-) labeled proteins. Ann N Y Acad Sci. 1957 Aug 30;70(1):26–48. doi: 10.1111/j.1749-6632.1957.tb35375.x. [DOI] [PubMed] [Google Scholar]
  16. GORDON A. H., HUMPHREY J. H. Measurement of intracellular albumin in rat liver. Biochem J. 1961 Mar;78:551–556. doi: 10.1042/bj0780551. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. INGBAR S. H., FREINKEL N. Regulation of the peripheral metabolism of the thyroid hormones. Recent Prog Horm Res. 1960;16:353–403. [PubMed] [Google Scholar]
  18. JULIAN L. M., LAWRENCE J. H., BERLIN N. I., HYDE G. M. Blood volume, body water and body fat of the horse. J Appl Physiol. 1956 May;8(6):651–653. doi: 10.1152/jappl.1956.8.6.651. [DOI] [PubMed] [Google Scholar]
  19. KATZ J., ROSENFELD S., SELLERS A. L. Sites of plasma albumin catabolism in the rat. Am J Physiol. 1961 Jun;200:1301–1306. doi: 10.1152/ajplegacy.1961.200.6.1301. [DOI] [PubMed] [Google Scholar]
  20. KELLEY M. B., ROBERTS S. Metabolism of plasma proteins in vitro. J Biol Chem. 1956 Oct;222(2):555–564. [PubMed] [Google Scholar]
  21. KLATSKIN G., BUNGARDS L. Bilirubinprotein linkages in serum and their relationship to the van den Bergh reaction. J Clin Invest. 1956 May;35(5):537–551. doi: 10.1172/JCI103307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. LESTER R., SCHMID R. Bile pigment excretion in amphibia. Nature. 1961 Apr 29;190:452–452. doi: 10.1038/190452a0. [DOI] [PubMed] [Google Scholar]
  23. LESTER R., SCHMID R. Intestinal absorption of bile pigments. I. The enterohepatic circulation of bilirubin in the rat. J Clin Invest. 1963 May;42:736–746. doi: 10.1172/JCI104766. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. LEVER W. F., GURD F. R. N., UROMA E., BROWN R. K., BARNES B. A., SCHMID K., SCHULTZ E. L. Chemical, clinical and immunological studies on the products of human plasma fractionation XL. Quantitative separation and determination of the protein components in small amounts of normal human plasma. J Clin Invest. 1951 Jan;30(1):99–111. doi: 10.1172/JCI102423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. LOHSS F., KALLEE E. Spurennachweis von Albumin durch Analyse von Antigen-Antikörperpraezipitaten. Clin Chim Acta. 1959 Jan;4(1):127–133. doi: 10.1016/0009-8981(59)90093-2. [DOI] [PubMed] [Google Scholar]
  26. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  27. Malloy H. T., Lowenstein L. HEREDITARY JAUNDICE IN THE RAT. Can Med Assoc J. 1940 Feb;42(2):122–125. [PMC free article] [PubMed] [Google Scholar]
  28. NAJJAR V. A., CHILDS B. The crystallization and properties of serum bilirubin. J Biol Chem. 1953 Sep;204(1):359–366. [PubMed] [Google Scholar]
  29. ODELL G. B. Studies in kernicterus. I. The protein binding of bilirubin. J Clin Invest. 1959 May;38(5):823–833. doi: 10.1172/JCI103864. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. ODELL G. B. The dissociation of bilirubin from albumin and its clinical implications. J Pediatr. 1959 Sep;55:268–279. doi: 10.1016/s0022-3476(59)80223-7. [DOI] [PubMed] [Google Scholar]
  31. OSTROW J. D., HAMMAKER L., SCHMID R. The preparation of crystalline bilirubin-C14. J Clin Invest. 1961 Aug;40:1442–1452. doi: 10.1172/JCI104375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. OSTROW J. D., JANDL J. H., SCHMID R. The formation of bilirubin from hemoglobin in vivo. J Clin Invest. 1962 Aug;41:1628–1637. doi: 10.1172/JCI104620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. SCHMID R., HAMMAKER L. Glucuronide formation in patients with constitutional hepatic dysfunction (Gilbert's disease). N Engl J Med. 1959 Jun 25;260(26):1310–1314. doi: 10.1056/NEJM195906252602603. [DOI] [PubMed] [Google Scholar]
  34. SCHMID R., HAMMAKER L. Metabolism and disposition of C14-bilirubin in congenital non-hemolytic jaundice. Trans Assoc Am Physicians. 1962;75:220–227. [PubMed] [Google Scholar]
  35. TOPI G. C. Contributo allo studio del legame bilirubin-proteico nei sieri itterici. Prog Med (Napoli) 1956 Feb 15;12(3):65–70. [PubMed] [Google Scholar]
  36. VITELLI A., GAIDANO G., CATTANEO C., TORRETTA A. Ulteriori contributi allo studio del trasporto della bilirubina nel siero mediante il frazionamento elettroforetico su carta. Minerva Med. 1957 Jul 7;48(54):2327–2331. [PubMed] [Google Scholar]
  37. WEINBREN K., BILLING B. H. Hepatic clearance of bilirubin as an index of cellular function in the regenerating rat liver. Br J Exp Pathol. 1956 Apr;37(2):199–204. [PMC free article] [PubMed] [Google Scholar]
  38. WESTPHAL U., OTT H., GEDIGK P. An welche Komponenten der Serumproteine ist das Bilirubin gebunden? Hoppe Seylers Z Physiol Chem. 1950 Jun;285(4-5):200–207. doi: 10.1515/bchm2.1950.285.4-5.200. [DOI] [PubMed] [Google Scholar]
  39. Weech A. A., Vann D., Grillo R. A. THE CLEARANCE OF BILIRUBIN FROM THE PLASMA. A MEASURE OF THE EXCRETING POWER OF THE LIVER. J Clin Invest. 1941 May;20(3):323–332. doi: 10.1172/JCI101226. [DOI] [PMC free article] [PubMed] [Google Scholar]

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