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. 1963 Nov;42(11):1735–1752. doi: 10.1172/JCI104859

AGGLUTINATION OF STORED ERYTHROCYTES BY A HUMAN SERUM. CHARACTERIZATION OF THE SERUM FACTOR AND ERYTHROCYTE CHANGES*

F L Ozer 1,2, H Chaplin Jr 1,2
PMCID: PMC289457  PMID: 14083164

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALTMAN K. I., TABECHIAN H., YOUNG L. E. Some aspects of the metabolism of red blood cells from patients with hemolytic anemias. Ann N Y Acad Sci. 1958 Oct 13;75(1):142–147. doi: 10.1111/j.1749-6632.1958.tb36859.x. [DOI] [PubMed] [Google Scholar]
  2. ANDERSON R., CASSELL M., MULLINAX G. L., CHAPLIN H., Jr Effect of normal cells on viscosity of sickle-cell blood. In vitro studies and report of six years' experience with a prophylactic program of "partial exchange transfusion". Arch Intern Med. 1963 Mar;111:286–294. doi: 10.1001/archinte.1963.03620270012003. [DOI] [PubMed] [Google Scholar]
  3. BALL H. A., WICK A. N., SANDERS C. Influence of glucose antimetabolites on the Walker tumor. Cancer Res. 1957 Apr;17(3):235–239. [PubMed] [Google Scholar]
  4. BARBAN S., SCHULZE H. O. The effects of 2-deoxyglucose on the growth and metabolism of cultured human cells. J Biol Chem. 1961 Jul;236:1887–1890. [PubMed] [Google Scholar]
  5. BARTLETT G. R., BARNET H. N. Changes in the phosphate compounds of the human red blood cell during blood bank storage. J Clin Invest. 1960 Jan;39:56–61. doi: 10.1172/JCI104026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BARTLETT G. R. Methods for the isolation of glycolytic intermediated by column chromatography with ion exchange resins. J Biol Chem. 1959 Mar;234(3):459–465. [PubMed] [Google Scholar]
  7. BISHOP C. Changes in the nucleotides of stored or incubated human blood. Transfusion. 1961 Nov-Dec;1:349–354. doi: 10.1111/j.1537-2995.1961.tb00073.x. [DOI] [PubMed] [Google Scholar]
  8. BISHOP C. Factors in the in vitro maintenance of the nucleotide pattern of whole human blood. Transfusion. 1961 Nov-Dec;1:355–359. doi: 10.1111/j.1537-2995.1961.tb00074.x. [DOI] [PubMed] [Google Scholar]
  9. BRENDEMOEN O. J. A cold agglutinin specifically active against stored red cells. Acta Pathol Microbiol Scand. 1952;31(4):574–578. doi: 10.1111/j.1699-0463.1952.tb00224.x. [DOI] [PubMed] [Google Scholar]
  10. BUCHANAN A. A. Lipid synthesis by human leucocytes in vitro. Biochem J. 1960 May;75:315–320. doi: 10.1042/bj0750315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Barron E. S., Miller Z. B., Bartlett G. R., Meyer J., Singer T. P. Reactivation by dithiols of enzymes inhibited by lewisite. Biochem J. 1947;41(1):69–74. [PMC free article] [PubMed] [Google Scholar]
  12. CARSON P. E. Glucose-6-phosphate dehydrogenase deficiency in hemolytic anemia. Fed Proc. 1960 Dec;19:995–1006. [PubMed] [Google Scholar]
  13. CECIL R., McPHEE J. R. The sulfur chemistry of proteins. Adv Protein Chem. 1959;14:255–389. doi: 10.1016/s0065-3233(08)60613-0. [DOI] [PubMed] [Google Scholar]
  14. CHAPLIN H., Jr, CASSELL M. Studies on anti-eluate sera. I. The production of antiglobulin (Coombs) sera in rabbits by the use of antibodies eluted from sensitized red blood cells. Vox Sang. 1960 Feb;5:32–42. doi: 10.1111/j.1423-0410.1960.tb03128.x. [DOI] [PubMed] [Google Scholar]
  15. DE GRUCHY G. C., LODER P. B., HENNESSY I. V. Haemolysis and glycolytic metabolism in hereditary elliptocytosis. Br J Haematol. 1962 Apr;8:168–179. doi: 10.1111/j.1365-2141.1962.tb06509.x. [DOI] [PubMed] [Google Scholar]
  16. EBAUGH F. G., Jr, EMERSON C. P., ROSS J. F. The use of radioactive chromium 51 as an erythrocyte tagging agent for the determination or red cell survival in vivo. J Clin Invest. 1953 Dec;32(12):1260–1276. doi: 10.1172/JCI102855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. FEGLER G. Relationship between reduced glutathione content and spontaneous haemolysis in shed blood. Nature. 1952 Oct 11;170(4328):624–625. doi: 10.1038/170624a0. [DOI] [PubMed] [Google Scholar]
  18. FORNAINI G., LEONCINI G., LUZZATTO L., SEGNI G. Glucose metabolism in human erythrocytes from normal and fava bean-sensitive subjects. J Clin Invest. 1962 Jul;41:1446–1453. doi: 10.1172/JCI104600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. GABRIO B. W., DONOHUE D. M., HUENNEKENS F. M., FINCH C. A. Erythrocyte preservation. VII. Acid-citrate-dextrose-inosine (ACDI) as a preservative for blood during storage at 4 degree C. J Clin Invest. 1956 Jun;35(6):657–663. doi: 10.1172/JCI103322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. GABRIO B. W., HENNESSEY M., THOMASSON J., FINCH C. A. Erythrocyte preservation. IV. In vitro reversibility of the storage lesion. J Biol Chem. 1955 Jul;215(1):357–367. [PubMed] [Google Scholar]
  21. GABRIO B. W., HUENNEKENS F. M., NURK E. Erythrocyte metabolism. I. Purine nucleoside phosphorylase. J Biol Chem. 1956 Aug;221(2):971–981. [PubMed] [Google Scholar]
  22. GELOTTE B., FLODIN P., KILLANDER J. Fractionation of human plasma proteins by gel filtration and zone electrophoresis or ion-exchange chromatography. Arch Biochem Biophys. 1962 Sep;Suppl 1:319–326. [PubMed] [Google Scholar]
  23. GOURLEY D. R. H. The role of adenosine triphosphate in the transport of phosphate in the human erythrocyte. Arch Biochem Biophys. 1952 Sep;40(1):1–12. doi: 10.1016/0003-9861(52)90066-0. [DOI] [PubMed] [Google Scholar]
  24. Hopkins F. G., Morgan E. J. The influence of thiol-groups in the activity of dehydrogenases. Biochem J. 1938 Mar;32(3):611–620. doi: 10.1042/bj0320611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. JACOB H. S., JANDL J. H. Effects of sulfhydryl inhibition on red blood cells. I. Mechanism of hemolysis. J Clin Invest. 1962 Apr;41:779–792. doi: 10.1172/JCI104536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. JANDL J. H., SIMMONS R. L. The agglutination and sensitization of red cells by metallic cations: interactions between multivalent metals and the red-cell membrane. Br J Haematol. 1957 Jan;3(1):19–38. doi: 10.1111/j.1365-2141.1957.tb05768.x. [DOI] [PubMed] [Google Scholar]
  27. JENKINS W. J., MARSH W. L. Autoimmune haemolytic anaemia. Three cases with antibodies specifically active against stored red cells. Lancet. 1961 Jul 1;2(7192):16–18. doi: 10.1016/s0140-6736(61)92706-4. [DOI] [PubMed] [Google Scholar]
  28. JONES N. C., MOLLISON P. L., ROBINSON M. A. Factors affecting the viability of erythrocytes stored in the frozen state. Proc R Soc Lond B Biol Sci. 1957 Dec 17;147(929):476–497. doi: 10.1098/rspb.1957.0067. [DOI] [PubMed] [Google Scholar]
  29. JORGENSEN S., OVERGAARD-HANSEN K., PRAETORIUS E. Rephosphorylation produced by inosine and adenosine of adenosine monophosphate and adenosine diphosphate in human erythrocytes. Nature. 1957 Jan 19;179(4551):152–153. doi: 10.1038/179152a0. [DOI] [PubMed] [Google Scholar]
  30. LOVELOCK J. E. Haemolysis by thermal shock. Br J Haematol. 1955 Jan;1(1):117–129. doi: 10.1111/j.1365-2141.1955.tb05493.x. [DOI] [PubMed] [Google Scholar]
  31. LOVELOCK J. E. The physical instability of human red blood cells. Biochem J. 1955 Aug;60(4):692–696. doi: 10.1042/bj0600692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. LOWY B. A., JAFFE E. R., VANDERHOFF G. A., CROOK L., LONDON I. M. The metabolism of purine nucleosides by the human erythrocyte in vitro. J Biol Chem. 1958 Jan;230(1):409–419. [PubMed] [Google Scholar]
  33. LOWY B. A., RAMOT B., LONDON I. M. Adenosine triphosphate metabolism in the rabbit erythrocyte in vivo and in vitro. Ann N Y Acad Sci. 1958 Oct 13;75(1):148–155. doi: 10.1111/j.1749-6632.1958.tb36860.x. [DOI] [PubMed] [Google Scholar]
  34. MAIZELS M. Factors in the active transport of cations. J Physiol. 1951 Jan;112(1-2):59–83. doi: 10.1113/jphysiol.1951.sp004509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. MOLLISON P. L., ROBINSON M. A. Observations on the effects of purine nucleosides on red-cell preservation. Br J Haematol. 1959 Oct;5:331–343. doi: 10.1111/j.1365-2141.1959.tb04043.x. [DOI] [PubMed] [Google Scholar]
  36. MURPHY J. R. Erythrocyte metabolism. II. Glucose metabolism and pathways. J Lab Clin Med. 1960 Feb;55:286–302. [PubMed] [Google Scholar]
  37. Marks P. A., Johnson A. B., Hirschberg E. EFFECT OF AGE ON THE ENZYME ACTIVITY IN ERYTHROCYTES. Proc Natl Acad Sci U S A. 1958 Jun;44(6):529–536. doi: 10.1073/pnas.44.6.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. NIRENBERG M. W., HOGG J. F. Inhibition of anaerobic glycolysis in Ehrlich ascites tumor cells by 2-deoxy-D-glucose. Cancer Res. 1958 Jun;18(5):518–521. [PubMed] [Google Scholar]
  39. PRANKERD T. A., ALTMAN K. I. A study of the metabolism of phosphorus in mammalian red cells. Biochem J. 1954 Dec;58(4):622–633. doi: 10.1042/bj0580622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. PRANKERD T. A. Chemical changes in stored blood, with observations on the effects of adenosine. Biochem J. 1956 Oct;64(2):209–213. doi: 10.1042/bj0640209a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. PRANKERD T. A. Revival of stored blood with guanosine; and its successful transfusion. Lancet. 1956 Apr 21;270(6921):469–471. doi: 10.1016/s0140-6736(56)90531-1. [DOI] [PubMed] [Google Scholar]
  42. Peters R. A., Sinclair H. M., Thompson R. H. An analysis of the inhibition of pyruvate oxidation by arsenicals in relation to the enzyme theory of vesication. Biochem J. 1946;40(4):516–524. [PMC free article] [PubMed] [Google Scholar]
  43. RITZMANN S. E., LEVIN W. C. Cryopathies: a review. Classification; diagnostic and therapeutic considerations. Arch Intern Med. 1961 May;107:754–772. doi: 10.1001/archinte.1961.03620050120014. [DOI] [PubMed] [Google Scholar]
  44. RUBINSTEIN D., KASHKET S., DENSTEDT O. F. Studies on the preservation of blood. IV. The influence of adenosine on the glycolytic activity of the erythrocyte during storage at 4 degrees C. Can J Biochem Physiol. 1956 Jan;34(1):61–74. [PubMed] [Google Scholar]
  45. Rapkine L. Sulphydryl groups and enzymic oxido-reduction. Biochem J. 1938 Oct;32(10):1729–1739. doi: 10.1042/bj0321729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. SHEETS R. F., HAMILTON H. E. A reversible effect on the metabolism of human erythrocytes by p-chloromercuribenzoic acid and N-ethyl maleimide. J Lab Clin Med. 1958 Jul;52(1):138–143. [PubMed] [Google Scholar]
  47. SIMON E. R., CHAPMAN R. G., FINCH C. A. Adenine in red cell preservation. J Clin Invest. 1962 Feb;41:351–359. doi: 10.1172/JCI104489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. SOLS A., CRANE R. K. Substrate specificity of brain hexokinase. J Biol Chem. 1954 Oct;210(2):581–595. [PubMed] [Google Scholar]
  49. STORTI E., VACCARI F., BALDINI E. Changes in red cells metabolism in presence of incomplete antibodies. Experientia. 1956 Mar 15;12(3):108–109. doi: 10.1007/BF02157180. [DOI] [PubMed] [Google Scholar]
  50. STRATTON F., RENTON P. H., RAWLINSON V. I. Serological difference between old and young cells. Lancet. 1960 Jun 25;1(7139):1388–1390. doi: 10.1016/s0140-6736(60)91157-0. [DOI] [PubMed] [Google Scholar]
  51. SZEINBERG A., MARKS P. A. Substances stimulating glucose catabolism by the oxidative reactions of the pentose phosphate pathway in human erythrocytes. J Clin Invest. 1961 Jun;40:914–924. doi: 10.1172/JCI104330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. SZEINBERG A., SHEBA C., ADAM A. Storage stability of blood with unstable glutathione. Isr Med J. 1958 Nov-Dec;17(11-12):265–267. [PubMed] [Google Scholar]
  53. TOWER D. B. The effects of 2-deoxy-D-glucose on metabolism of slices of cerebral cortex incubated in vitro. J Neurochem. 1958 Dec;3(2):185–205. doi: 10.1111/j.1471-4159.1958.tb12625.x. [DOI] [PubMed] [Google Scholar]
  54. WIEME R. J. An improved technique of agar-gel electrophoresis on microscope slides. Clin Chim Acta. 1959 May;4(3):317–321. doi: 10.1016/0009-8981(59)90096-8. [DOI] [PubMed] [Google Scholar]
  55. WIENER A. S., UNGER L. J., COHEN L., FELDMAN J. Type-specific cold auto-antibodies as a cause of acquired hemolytic anemia and hemolytic transfusion reactions: biologic test with bovine red cells. Ann Intern Med. 1956 Feb;44(2):221–240. doi: 10.7326/0003-4819-44-2-221. [DOI] [PubMed] [Google Scholar]
  56. WOODWARD G. E., HUDSON M. T. The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues. Cancer Res. 1954 Sep;14(8):599–605. [PubMed] [Google Scholar]
  57. YORK D. R. Apples for desserts, salads, pies. Hosp Manage. 1954 Sep;78(3):105–106. [PubMed] [Google Scholar]

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