Skip to main content
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1963 Nov;42(11):1816–1834. doi: 10.1172/JCI104866

ANTIBODY-SUPPRESSIBLE AND NONSUPPRESSIBLE INSULIN-LIKE ACTIVITIES IN HUMAN SERUM AND THEIR PHYSIOLOGIC SIGNIFICANCE. AN INSULIN ASSAY WITH ADIPOSE TISSUE OF INCREASED PRECISION AND SPECIFICITY*

E R Froesch 1, H Bürgi 1, E B Ramseier 1, P Bally 1, A Labhart 1
PMCID: PMC289464  PMID: 14083170

Full text

PDF
1816

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANTONIADES H. N., GUNDERSEN K., PYLE H. M. Studies on the state of insulin in blood: the role of glucose in the in vivo dissociation of insulin complexes. Endocrinology. 1961 Jul;69:163–169. doi: 10.1210/endo-69-1-163. [DOI] [PubMed] [Google Scholar]
  2. ANTONIADES H. N. Studies on the state of insulin in blood: the state and transport of insulin in blood. Endocrinology. 1961 Jan;68:7–16. doi: 10.1210/endo-68-1-7. [DOI] [PubMed] [Google Scholar]
  3. BALL E. G., MERRILL M. A. A manometric assay of insulin and some results of the application of the method to sera and islet-containing tissues. Endocrinology. 1961 Sep;69:596–607. doi: 10.1210/endo-69-3-596. [DOI] [PubMed] [Google Scholar]
  4. BEIGELMAN P. M. Insulin-like activity of normal and diabetic human serum. Diabetes. 1959 Jan-Feb;8(1):29–35. doi: 10.2337/diab.8.1.29. [DOI] [PubMed] [Google Scholar]
  5. BUERGI H., RAMSEIER E. B., FORESCH E. R., BALLY P., LABHART A. ["Free" and "bound" insulin in serum from patients with beta-islet cell adenoma]. Helv Med Acta. 1962 Dec;29:527–534. [PubMed] [Google Scholar]
  6. BUERGI H., SCHWARZ K., KOPETZ K., FROESCH E. R. FATE OF RAT INSULIN IN RAT-LIVER PERFUSION STUDIED BY ADIPOSE-TISSUE ASSAY. Lancet. 1963 Aug 17;2(7303):314–316. doi: 10.1016/s0140-6736(63)92987-8. [DOI] [PubMed] [Google Scholar]
  7. CUNNINGHAM N. F. The insulin activity of bovine and ovine blood plasma. II. The insulin-like action of extracts of bovine and ovine blood plasma. J Endocrinol. 1962 Sep;25:43–52. doi: 10.1677/joe.0.0250043. [DOI] [PubMed] [Google Scholar]
  8. DITSCHUNEIT H., AHN C. S., PFEIFFER M., PFEIFFER E. F. [On the determination of insulin in the blood of epididymal fatty tissue of the rat with the aid of marked glucose. I. Method and margins of error]. Klin Wochenschr. 1959 Dec 1;37:1234–1239. doi: 10.1007/BF01486386. [DOI] [PubMed] [Google Scholar]
  9. DITSCHUNEIT H., AHN C. S., PFEIFFER M., PFEIFFER E. F. [On the determination of insulin in the blood of epididymal fatty tissue of the rat with the aid of marked glucose. I. Method and margins of error]. Klin Wochenschr. 1959 Dec 1;37:1234–1239. doi: 10.1007/BF01486386. [DOI] [PubMed] [Google Scholar]
  10. FROESCH E. R., BALLY P., GUHL U., RAMSEIER E., LABHART A. [The effect of glucagons on adipose tissue]. Schweiz Med Wochenschr. 1960 Nov 19;90:1329–1332. [PubMed] [Google Scholar]
  11. FROESCH E. R., GINSBERG J. L. Fructose metabolism of adipose tissue. I. Comparison of fructose and glucose metabolism in epididymal adipose tissue of normal rats. J Biol Chem. 1962 Nov;237:3317–3324. [PubMed] [Google Scholar]
  12. GORDON R. S., Jr Unesterified fatty acid in human blood plasma. II. The transport function of unesterified fatty acid. J Clin Invest. 1957 Jun;36(6 Pt 1):810–815. doi: 10.1172/JCI103486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. HUMBEL R. E. [Measurement of serum insulin activity with epididymal fat tissue of rats in vitro]. Experientia. 1959 Jul 15;15:256–258. doi: 10.1007/BF02158069. [DOI] [PubMed] [Google Scholar]
  14. JEANRENAUD B. Dynamic aspects of adipose tissue metabolism: a review. Metabolism. 1961 Jul;10:535–581. [PubMed] [Google Scholar]
  15. JUNGAS R. L., BALL E. G. Studies on the metabolism of adipose tissue. V. The effect of a growth hormone preparation and insulin on the oxygen consumption, glucose uptake, and lactic acid production. J Biol Chem. 1960 Jul;235:1894–1899. [PubMed] [Google Scholar]
  16. KIPNIS D. M., HELMREICH E., CORI C. F. Studies of tissue permeability. IV. The distribution of glucose between plasma and muscle. J Biol Chem. 1959 Jan;234(1):165–170. [PubMed] [Google Scholar]
  17. LEBOEUF B., CAHILL G. F., Jr Studies on rat adipose tissue in vitro. VIII. Effect of preparations of pituitary adrenocorticotropic and growth hormones on glucose metabolism. J Biol Chem. 1961 Jan;236:41–46. [PubMed] [Google Scholar]
  18. LEONARDS J. R., LANDAU B. R., BARTSCH G. Assay of insulin-like activity with rat epididymal fat pad. J Lab Clin Med. 1962 Oct;60:552–570. [PubMed] [Google Scholar]
  19. LOWY C., BLANSHARD G., PHEAR D. Antagonism of insulin by albumin. Lancet. 1961 Apr 15;1(7181):802–804. doi: 10.1016/s0140-6736(61)90121-0. [DOI] [PubMed] [Google Scholar]
  20. LYNGSOE J. Determination of the insulin-like activity in serum using rat epididymal adipose tissue. Scand J Clin Lab Invest. 1961;13:628–636. doi: 10.3109/00365516109137336. [DOI] [PubMed] [Google Scholar]
  21. LYNGSOE J. The insulin-like activity in serum determined by the rat epididymal fat method. I. Normal values in undiluted and diluted serum, and the effect of ingestion of glucose. Acta Med Scand. 1962 Mar;171:365–375. [PubMed] [Google Scholar]
  22. MARTIN D. B., RENOLD A. E., DAGENAIS Y. M. An assay for insulin-like activity using rat adipose tissue. Lancet. 1958 Jul 12;2(7037):76–77. doi: 10.1016/s0140-6736(58)91246-7. [DOI] [PubMed] [Google Scholar]
  23. MOLONEY P. J., COVAL M. Antigenicity of insulin: diabetes induced by specific antibodies. Biochem J. 1955 Feb;59(2):179–185. doi: 10.1042/bj0590179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. RENOLD A. E., ASHMORE J., HASTINGS A. B. Regulation of carbohydrate metabolism in isolated tissues. Vitam Horm. 1956;14:139–185. doi: 10.1016/s0083-6729(08)60300-3. [DOI] [PubMed] [Google Scholar]
  25. RENOLD A. E., MARTIN D. B., DAGENAIS Y. M., STEINKE J., NICKERSON R. J., SHEPS M. C. Measurement of small quantities of insulin-like activity using rat adipose tissue. I. A proposed procedure. J Clin Invest. 1960 Sep;39:1487–1498. doi: 10.1172/JCI104168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. SAMAAN N. A., DEMPSTER W. J., FRASER R., STILLMAN D. Changes in levels of 'atypical' circulating insulin after infusing 'typical' insulin through the liver. J Endocrinol. 1963 Mar;26:1–10. doi: 10.1677/joe.0.0260001. [DOI] [PubMed] [Google Scholar]
  27. SAMAAN N., STILLMAN D., FRASER R. Abnormalities of serum insulin-like activity in liver-disease. Lancet. 1962 Dec 22;2(7269):1287–1290. doi: 10.1016/s0140-6736(62)90845-0. [DOI] [PubMed] [Google Scholar]
  28. SAMOLS E., RYDER J. A. Studies on tissue uptake of insulin in man using a differential immunoassay for endogenous and exogenous insulin. J Clin Invest. 1961 Nov;40:2092–2102. doi: 10.1172/JCI104435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. SELTZER H. S., SMITH W. L. Plasma insulin activity after glucose: an index of insulogenic reserve in normal and diabetic man. Diabetes. 1959 Nov-Dec;8:417–424. doi: 10.2337/diab.8.6.417. [DOI] [PubMed] [Google Scholar]
  30. SHAW W. N., SHUEY E. W. The presence of two forms of insulin in normal human serum. Biochemistry. 1963 Mar-Apr;2:286–289. doi: 10.1021/bi00902a015. [DOI] [PubMed] [Google Scholar]
  31. STEINKE J., SIREK A., LAURIS V., LUKENS F. D., RENOLD A. E. Measurement of small quantities of insulin-like activity with rat adipose tissue. III. Persistence of serum insulin-like activity after pancreatectomy. J Clin Invest. 1962 Sep;41:1699–1707. doi: 10.1172/JCI104627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Sheps M. C., Nickerson R. J., Dagenais Y. M., Steinke J., Martin D. B., Renold A. F. MEASUREMENT OF SMALL QUANTITIES OF INSULIN-LIKE ACTIVITY USING RAT ADIPOSE TISSUE. II. EVALUATION OF PERFORMANCE. J Clin Invest. 1960 Sep;39(9):1499–1510. doi: 10.1172/JCI104169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. TAYLOR K. W., RANDLE P. J. The effect of insulin antiserum on the insulin activity of serum and protein fractions of serum. J Endocrinol. 1959 Dec;19:221–231. doi: 10.1677/joe.0.0190221. [DOI] [PubMed] [Google Scholar]
  34. VALLANCE-OWEN J., HURLOCK B. Estimation of plasma-insulin by the rat diaphragm method. Lancet. 1954 Jan 9;266(6802):68–70. doi: 10.1016/s0140-6736(54)90820-x. [DOI] [PubMed] [Google Scholar]
  35. VALLANCE-OWEN J., LILLEY M. D. An insulin antagonist associated with plasma-albumin. Lancet. 1961 Apr 15;1(7181):804–806. doi: 10.1016/s0140-6736(61)90122-2. [DOI] [PubMed] [Google Scholar]
  36. WEINGES K. F., WOERNER H. [On the effect of insulin and glucagon on glucose metabolism of the epididymal fat appendix of rats in vitro. I. The effect of insulin and the resulting possibility of determination of an insulin-like activity in the human blood]. Klin Wochenschr. 1961 Mar 1;39:238–243. doi: 10.1007/BF01483520. [DOI] [PubMed] [Google Scholar]
  37. WILLEBRANDS A. F., VAN DER GELD H., GROEN J. Determination of serum insulin using the isolated rat diaphragm; the effect of serum dilution. Diabetes. 1958 Mar-Apr;7(2):119–124. doi: 10.2337/diab.7.2.119. [DOI] [PubMed] [Google Scholar]
  38. WINEGRAD A. I., SHAW W. N., LUKENS F. D., STADIE W. C., RENOLD A. E. Effects of growth hormone in vitro on the metabolism of glucose in rat adipose tissue. J Biol Chem. 1959 Jul;234(7):1922–1928. [PubMed] [Google Scholar]
  39. WRIGHT P. H. Plasma-insulin estimation by the rat-diaphragm method. Lancet. 1957 Sep 28;273(6996):621–624. doi: 10.1016/s0140-6736(57)91947-5. [DOI] [PubMed] [Google Scholar]
  40. YALOW R. S., BERSON S. A. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960 Jul;39:1157–1175. doi: 10.1172/JCI104130. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES