Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1964 Feb;43(2):201–216. doi: 10.1172/JCI104905

Effects of Ethacrynic Acid (a New Saluretic Agent) on Renal Diluting and Concentrating Mechanisms: Evidence for Site of Action in the Loop of Henle*

Martin Goldberg 1,†, Donna K McCurdy 1, Elwood L Foltz 1, Lewis W Bluemle Jr 1
PMCID: PMC289514  PMID: 14162529

Full text

PDF

Images in this article

205Image
on p.205
209Image
on p.209
210Image
on p.210

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AU W. Y., RAISZ L. G. Studies on the renal concentrating mechanism, 5. Effect of diuretic agents. J Clin Invest. 1960 Aug;39:1302–1311. doi: 10.1172/JCI104147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BECKER E. L., GINN H. E. Free water excretion in normal dogs. Am J Physiol. 1962 Jun;202:1131–1135. doi: 10.1152/ajplegacy.1962.202.6.1131. [DOI] [PubMed] [Google Scholar]
  3. BERLINER R. W., KENNEDY T. J., Jr, HILTON J. G. Renal mechanisms for excretion of potassium. Am J Physiol. 1950 Aug 1;162(2):348–367. doi: 10.1152/ajplegacy.1950.162.2.348. [DOI] [PubMed] [Google Scholar]
  4. COTLOVE E., TRANTHAM H. V., BOWMAN R. L. An instrument and method for automatic, rapid, accurate, and sensitive titration of chloride in biologic samples. J Lab Clin Med. 1958 Mar;51(3):461–468. [PubMed] [Google Scholar]
  5. COUNIHAN T. B., EVANS B. M., MILNE M. D. Observations on the pharmacology of the carbonic anhydrase inhibitor diamox. Clin Sci. 1954 Nov;13(4):583–598. [PubMed] [Google Scholar]
  6. DE WARDENER H. E., DEL GRECO F. The influence of solute excretion rate on the production of a hypotonic urine in man. Clin Sci. 1955 Nov;14(4):715–723. [PubMed] [Google Scholar]
  7. EARLEY L. E., KAHN M., ORLOFF J. The effects of infusions of chlorothiazide on urinary dilution and concentration in the dog. J Clin Invest. 1961 May;40:857–866. doi: 10.1172/JCI104320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. EPSTEIN F. H., BECK D., CARONE F. A., LEVITIN H., MANITIUS A. Changes in renal concentrating ability produced by parathyroid extract. J Clin Invest. 1959 Jul;38(7):1214–1221. doi: 10.1172/JCI103896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GILL J. R., Jr, BARTTER F. C. On the impairment of renal concentrating ability in prolonged hypercalcemia and hypercalciuria in man. J Clin Invest. 1961 Apr;40:716–722. doi: 10.1172/JCI104305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GOLDSTEIN M. H., LEVITT M. F., HAUSER A. D., POLIMEROS D. Effect of meralluride on solute and water excretion in hydrated man: comments on site of action. J Clin Invest. 1961 Apr;40:731–742. doi: 10.1172/JCI104307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. GOTTSCHALK C. W., MYLLE M. Micropuncture study of the mammalian urinary concentrating mechanism: evidence for the countercurrent hypothesis. Am J Physiol. 1959 Apr;196(4):927–936. doi: 10.1152/ajplegacy.1959.196.4.927. [DOI] [PubMed] [Google Scholar]
  12. HEINEMANN H. O., BECKER E. L. Effect of a mercurial diuretic on the excretion of free water in diabetes insipidus. J Appl Physiol. 1958 Jan;12(1):51–54. doi: 10.1152/jappl.1958.12.1.51. [DOI] [PubMed] [Google Scholar]
  13. HEINEMANN H. O., DEMARTINI F. E., LARAGH J. H. The effect of chlorothiazide on renal excretion of electrolytes and free water. Am J Med. 1959 Jun;26(6):853–861. doi: 10.1016/0002-9343(59)90207-4. [DOI] [PubMed] [Google Scholar]
  14. JAENIKE J. R., BERLINGER R. W. A study of distal renal tubular functions by a modified stop flow technique. J Clin Invest. 1960 Mar;39:481–490. doi: 10.1172/JCI104062. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. KLUMPER J. D., ULLRICH K. J., HILGER H. H. Das Verhalten des Harnstoffs in den Sammelrohren der Säugetierniere. Pflugers Arch. 1958;267(3):238–243. doi: 10.1007/BF00362427. [DOI] [PubMed] [Google Scholar]
  16. LAMBIE A. T., ROBSON J. S. The effect of mersalyl on the renal tubular reabsorption of solute free water. Clin Sci. 1961 Feb;20:123–129. [PubMed] [Google Scholar]
  17. LASSITER W. E., GOTTSCHALK C. W., MYLLE M. Micropuncture study of net transtubular movement of water and urea in nondiuretic mammalian kidney. Am J Physiol. 1961 Jun;200:1139–1147. doi: 10.1152/ajplegacy.1961.200.6.1139. [DOI] [PubMed] [Google Scholar]
  18. MELVIN K. E., FARRELLY R. O., NORTH J. D. Ethacrynic acid: a new oral diuretic. Br Med J. 1963 Jun 8;1(5344):1521–1524. doi: 10.1136/bmj.1.5344.1521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. ORLOFF J., WAGNER H. N., Jr, DAVIDSON D. G. The effect of variations in solute excretion and vasopressin dosage on the excretion of water in the dog. J Clin Invest. 1958 Mar;37(3):458–464. doi: 10.1172/JCI103625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. PORUSH J. G., GOLDSTEIN M. H., EISNER G. M., LEVITT M. F. Effect of organomercurials on the renal concentrating operation in hydropenic man: comments on site of action. J Clin Invest. 1961 Aug;40:1475–1485. doi: 10.1172/JCI104378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. RAISZ L. G., AU W. Y., SCHEER R. L. Studies on the renal concentrating mechanism. IV. Osmotic diuresis. J Clin Invest. 1959 Oct;38:1725–1732. doi: 10.1172/JCI103951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. SCHULTZ E. M., CRAGOE E. J., Jr, BICKING J. B., BOLHOFER W. A., SPRAGUE J. M. ALPHA, BETA-UNSATURATED KETONE DERIVATIVES OF ARYLOXYACETIC ACIDS, A NEW CLASS OF DIURETICS. J Med Pharm Chem. 1962 May;91:660–662. doi: 10.1021/jm01238a030. [DOI] [PubMed] [Google Scholar]
  23. ULLRICH K. J., EIGLER F. W. Sekretion von Wasserstoffionen in den Sammelrohren des Säugetierniere. Pflugers Arch. 1958;267(5):491–496. doi: 10.1007/BF00361735. [DOI] [PubMed] [Google Scholar]
  24. ULLRICH K. J., HILGER H. H., KLUMPER J. D. Sekretion von Ammoniumionen in den Sammelrohren der Säugetierniere. Pflugers Arch. 1958;267(3):244–250. doi: 10.1007/BF00362428. [DOI] [PubMed] [Google Scholar]
  25. ULLRICH K. J., KRAMER K., BOYLAN J. W. Present knowledge of the counter-current system in the mammalian kidney. Prog Cardiovasc Dis. 1961 Mar;3:395–431. doi: 10.1016/s0033-0620(61)80001-7. [DOI] [PubMed] [Google Scholar]
  26. WALSER M., DAVIDSON D. G., ORLOFF J. The renal clearance of alkali-stable inulin. J Clin Invest. 1955 Oct;34(10):1520–1523. doi: 10.1172/JCI103204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. WIRZ H. Der osmotische Druck in den corticalen Tubuli der Rattenniere. Helv Physiol Pharmacol Acta. 1956;14(3):353–362. [PubMed] [Google Scholar]
  28. ZAK G. A., BRUN C., SMITH H. W. The mechanism of formation of osmotically concentrated urine during the antidiuretic state. J Clin Invest. 1954 Jul;33(7):1064–1074. doi: 10.1172/JCI102974. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES