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. Author manuscript; available in PMC: 2011 Jun 22.
Published in final edited form as: Biochemistry. 2010 Jun 22;49(24):5048–5056. doi: 10.1021/bi1005046

Figure 1.

Figure 1

(a) Binuclear manganese cluster in rat arginase I (1RLA) (20); Mn2+ ions appear as pink spheres, and the metal-bridging hydroxide ion is shown as a red sphere. (b) Zinc binding site in HDAC8 (1T64) (23); the Zn2+ ion appears as a gray sphere, and the zinc-bound inhibitor trichostatin A is not shown for clarity. Metal ligands topologically identical to those in rat arginase I are color-coded accordingly. (c) First step in the proposed arginase mechanism (67, 68). (d) First step in the proposed HDAC8 mechanism (21, 36, 47).