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. 1964 Feb;43(2):237–246. doi: 10.1172/JCI104908

The Acute Effect of Hydrocortisone on Hepatic Glucose Output and Peripheral Glucose Utilization*

Frank R Lecocq 1,, David Mebane 1,, Leonard L Madison 1
PMCID: PMC289517  PMID: 14162532

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELOVE W. A., PASCHKIS K. E. Comparison of the diabetogenic action of cortisone and growth hormone in different species. Endocrinology. 1954 Nov;55(5):637–654. doi: 10.1210/endo-55-5-637. [DOI] [PubMed] [Google Scholar]
  2. ALTSZULER N., STEELE R., WALL J. S., DE BODO R. C. Effects of adrenocortical steroids on carbohydrate metabolism in hypophysectomized dogs; studies with C14-labeled glucose. Am J Physiol. 1957 Oct;191(1):29–33. doi: 10.1152/ajplegacy.1957.191.1.29. [DOI] [PubMed] [Google Scholar]
  3. ASHMORE J., STRICKER F., LOVE W. C., KILSHEIMER G. Cortisol stimulation of glycogen synthesis in fasted rats. Endocrinology. 1961 Apr;68:599–606. doi: 10.1210/endo-68-4-599. [DOI] [PubMed] [Google Scholar]
  4. BLAIR A., SEGAL S. The isolation of blood glucose as potassium gluconate. J Lab Clin Med. 1960 Jun;55:959–964. [PubMed] [Google Scholar]
  5. BOUTWELL R. K., CHIANG R. The acute effect of cortisone treatment on the utilization of glucose by the mouse. Arch Biochem Biophys. 1954 Jun;50(2):461–472. doi: 10.1016/0003-9861(54)90062-4. [DOI] [PubMed] [Google Scholar]
  6. Bradley S. E., Ingelfinger F. J., Bradley G. P., Curry J. J. THE ESTIMATION OF HEPATIC BLOOD FLOW IN MAN. J Clin Invest. 1945 Nov;24(6):890–897. doi: 10.1172/JCI101676. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. COMBES B. Estimation of hepatic blood flow in man and in dogs by I 131-labeled rose bengal; simultaneous comparison with sulfobromophthalein sodium. J Lab Clin Med. 1960 Oct;56:537–543. [PubMed] [Google Scholar]
  8. DE BODO R. C., ALTSZULER N., DUNN A., STEELE R., ARMSTRONG D. T., BISHOP J. S. Effects of exogenous and endogenous insulin on glucose utilization and production. Ann N Y Acad Sci. 1959 Sep 25;82:431–451. doi: 10.1111/j.1749-6632.1959.tb44924.x. [DOI] [PubMed] [Google Scholar]
  9. DE BODO R. C., ALTSZULER N. Insulin hypersensitivity and physiological insulin antagonists. Physiol Rev. 1958 Jul;38(3):389–445. doi: 10.1152/physrev.1958.38.3.389. [DOI] [PubMed] [Google Scholar]
  10. FRAWLEY T. F. The role of the adrenal cortex in glucose and pyruvic acid metabolism in man including the use of intravenous hydrocortisone in acute hypoglycemia. Ann N Y Acad Sci. 1955 May 27;61(2):464–493. doi: 10.1111/j.1749-6632.1955.tb42498.x. [DOI] [PubMed] [Google Scholar]
  11. FROESCH E. R., WINEGRAD A. I., RENOLD A. E., THORN G. W. Mechanism of the glucosuria produced by the administration of steroids with glucocorticoid activity. J Clin Invest. 1958 Apr;37(4):524–532. doi: 10.1172/JCI103634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. GLENN E. M., BOWMAN B. J., BAYER R. B., MEYER C. E. Hydrocortisone and some of its effects on intermediary metabolism. I. In vivo studies. Endocrinology. 1961 Mar;68:386–410. doi: 10.1210/endo-68-3-386. [DOI] [PubMed] [Google Scholar]
  13. GLENN E. M., STAFFORD R. O., LYSTER S. C., BOWMAN B. J. Relation between biological activity of hydrocortisone analogues and their rates of inactivation by rat liver enzyme systems. Endocrinology. 1957 Aug;61(2):128–142. doi: 10.1210/endo-61-1-128. [DOI] [PubMed] [Google Scholar]
  14. HILZ H., TARNOWSKI W., AREND P. Glucose polymerisation and cortisol. Biochem Biophys Res Commun. 1963 Mar 25;10:492–497. doi: 10.1016/0006-291x(63)90385-1. [DOI] [PubMed] [Google Scholar]
  15. HUNTER N. W., JOHNSON C. E. The effects of hydrocortisone on glycogen storage and phosphorylase activity of frog liver. J Cell Comp Physiol. 1960 Jun;55:275–280. doi: 10.1002/jcp.1030550310. [DOI] [PubMed] [Google Scholar]
  16. HYDE P. M. Liver glycogen deposition after intravenous and intragastric administration of cortisol-4-C14 to rats. Endocrinology. 1957 Dec;61(6):774–779. doi: 10.1210/endo-61-6-774. [DOI] [PubMed] [Google Scholar]
  17. INGLE D. J. Experimental steroid diabetes. Diabetes. 1956 May-Jun;5(3):187–193. doi: 10.2337/diab.5.3.187. [DOI] [PubMed] [Google Scholar]
  18. KUPPERMAN H. S., PERSKY M., LINSK J., ISAACS M., ROSENBLUTH M. The paradoxical effect of intravenous hydrocortisone upon carbohydrate metabolism. Ann N Y Acad Sci. 1955 May 27;61(2):494–501. doi: 10.1111/j.1749-6632.1955.tb42499.x. [DOI] [PubMed] [Google Scholar]
  19. LEBOEUF B., RENOLD A. E., CAHILL G. F., Jr Studies on rat adipose tissue in vitro. IX. Further effects cortisol on glucose metabolism. J Biol Chem. 1962 Apr;237:988–991. [PubMed] [Google Scholar]
  20. MADISON L. L., COMBES B., ADAMS R., STRICKLAND W. The physiological significance of the secretion of endogenous insulin into the portal circulation. III. Evidence for a direct immediate effect of insulin on the balance of glucose across the liver. J Clin Invest. 1960 Mar;39:507–522. doi: 10.1172/JCI104065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. MORGAN H. E., HENDERSON M. J., REGEN D. M., PARK C. R. Regulation of glucose uptake in heart muscle from normal and alloxan-diabetic rats: the effects of insulin, growth hormone, cortisone, and anoxia. Ann N Y Acad Sci. 1959 Sep 25;82:387–402. doi: 10.1111/j.1749-6632.1959.tb44920.x. [DOI] [PubMed] [Google Scholar]
  22. MYERS J. D. Net splanchnic glucose production in normal man and in various disease states. J Clin Invest. 1950 Nov;29(11):1421–1429. doi: 10.1172/JCI102380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. PAPPER S., SAXON L., PROUT T. E., ALPERT H. C. The effects of cortisone on the fructose and glucose tolerance tests of normal men. J Lab Clin Med. 1956 Jul;48(1):13–19. [PubMed] [Google Scholar]
  24. RANDLE P. J., GARLAND P. B., HALES C. N., NEWSHOLME E. A. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963 Apr 13;1(7285):785–789. doi: 10.1016/s0140-6736(63)91500-9. [DOI] [PubMed] [Google Scholar]
  25. RIDDICK F. A., Jr, REISLER D. M., KIPNIS D. M. The sugar transport system in striated muscle. Effect of growth hormone, hydrocortisone and alloxan diabetes. Diabetes. 1962 May-Jun;11:171–178. [PubMed] [Google Scholar]
  26. SCHAMBYE P., TARDING F. Changes induced by insulin and tolbutamide in the glucose output of the liver. Ann N Y Acad Sci. 1959 Mar 30;74(3):557–569. doi: 10.1111/j.1749-6632.1959.tb39580.x. [DOI] [PubMed] [Google Scholar]
  27. SEARLE G. L., STRISOWER E. H., CHAIKOFF I. L. Glucose pool and glucose space in the normal and diabetic dog. Am J Physiol. 1954 Feb;176(2):190–194. doi: 10.1152/ajplegacy.1954.176.2.190. [DOI] [PubMed] [Google Scholar]
  28. SENSENBACH W., MADISON L., OCHS L. The effect of ACTH and cortisone on cerebral blood flow and metabolism. J Clin Invest. 1953 Apr;32(4):372–379. doi: 10.1172/JCI102748. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. THORN G. W., RENOLD A. E., CAHILL G. F., Jr The adrenal and diabetes: some interactions and interrelations. Diabetes. 1959 Sep-Oct;8:337–351. doi: 10.2337/diab.8.5.337. [DOI] [PubMed] [Google Scholar]
  30. WELT I. D., STETTEN D., Jr, INGLE D. J., MORLEY E. H. Effect of cortisone upon rates of glucose production and oxidation in the rat. J Biol Chem. 1952 May;197(1):57–66. [PubMed] [Google Scholar]
  31. WEST K. M. Response of the blood glucose to glucocorticoids in man; determination of the hyperglycemic potencies of glucocorticoids. Diabetes. 1959 Jan-Feb;8(1):22–28. doi: 10.2337/diab.8.1.22. [DOI] [PubMed] [Google Scholar]
  32. WILLMER J. S. Changes in hepatic enzyme levels after adrenalectomy. I. Phosphorylase, phosphoglucomutase, and phosphoglucoseisomerase. Can J Biochem Physiol. 1960 Oct;38:1095–1104. [PubMed] [Google Scholar]

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