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. 1964 Feb;43(2):247–257. doi: 10.1172/JCI104909

The Intraluminal Phase of Fat Digestion in Man: The Lipid Content of the Micellar and Oil Phases of Intestinal Content Obtained during Fat Digestion and Absorption*

Alan F Hofmann 1,†, Bengt Borgström 1
PMCID: PMC289518  PMID: 14162533

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AHRENS E. H., Jr, BORGSTROM B. Exchange of free fatty acids and glyceride fatty acids during fat digestion in the human intestine. J Biol Chem. 1956 Apr;219(2):665–675. [PubMed] [Google Scholar]
  2. BLANKENHORN D. H., AHRENS E. H., Jr Extraction, isolation, and identification of hydrolytic products of triglyceride digestion in man. J Biol Chem. 1955 Jan;212(1):69–81. [PubMed] [Google Scholar]
  3. BLANKENHORN D. H., HIRSCH J., AHRENS E. H., Jr Transintestinal intubation: technic for measurement of gut length and physiologic sampling at known loci. Proc Soc Exp Biol Med. 1955 Mar;88(3):356–362. doi: 10.3181/00379727-88-21588. [DOI] [PubMed] [Google Scholar]
  4. BORGSTROEM B., LUNDH G., HOFMANN A. THE SITE OF ABSORPTION OF CONJUGATED BILE SALTS IN MAN. Gastroenterology. 1963 Aug;45:229–238. [PubMed] [Google Scholar]
  5. BORGSTROM B., DAHLQVIST A., LUNDH G., SJOVALL J. Studies of intestinal digestion and absorption in the human. J Clin Invest. 1957 Oct;36(10):1521–1536. doi: 10.1172/JCI103549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BORGSTROM B. On the action of pancreatic lipase on triglycerides in vivo and in vitro. Acta Physiol Scand. 1952 Jun 19;25(4):328–347. doi: 10.1111/j.1748-1716.1952.tb00885.x. [DOI] [PubMed] [Google Scholar]
  7. CONSTANTIN M. J., PASERO L., DESNUELLE P. [Additional remarks on the hydrolysis of triglycerides by pancreas lipase]. Biochim Biophys Acta. 1960 Sep 9;43:103–109. doi: 10.1016/0006-3002(60)90412-1. [DOI] [PubMed] [Google Scholar]
  8. DAHLQVIST A., BORGSTROM B. Digestion and absorption of disaccharides in man. Biochem J. 1961 Nov;81:411–418. doi: 10.1042/bj0810411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. DESNUELLE P., CONSTANTIN M. J. Formation de glycérides partiels pendant la lipolyse des triglycérides dans l'intestin. Biochim Biophys Acta. 1952 Nov;9(5):531–537. doi: 10.1016/0006-3002(52)90203-5. [DOI] [PubMed] [Google Scholar]
  10. DOWSE C. M., SAUNDERS J. A., SCHOFIELD B. The composition of lipid from jejunal contents of the dog after a fatty meal. J Physiol. 1956 Dec 28;134(3):515–526. doi: 10.1113/jphysiol.1956.sp005661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. FRAZER A. C. Fat absorption and its disorders. Br Med Bull. 1958 Sep;14(3):212–220. doi: 10.1093/oxfordjournals.bmb.a069686. [DOI] [PubMed] [Google Scholar]
  12. Frazer A. C., Sammons H. G. The formation of mono- and di-glycerides during the hydrolysis of triglyceride by pancreatic lipase. Biochem J. 1945;39(2):122–128. doi: 10.1042/bj0390122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Frazer A. C., Schulman J. H., Stewart H. C. Emulsification of fat in the intestine of the rat and its relationship to absorption. J Physiol. 1944 Dec 15;103(3):306–316. doi: 10.1113/jphysiol.1944.sp004079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. GIDEZ L. I., KARNOVSKY M. L. The metabolism of glyceride-glycerol. J Biol Chem. 1956 Nov;223(1):293–306. [PubMed] [Google Scholar]
  15. HOFMANN A. F., BORGSTROM B. Hydrolysis of long-chain monoglycerides in micellar solution by pancreatic lipase. Biochim Biophys Acta. 1963 Jun 18;70:317–331. doi: 10.1016/0006-3002(63)90755-8. [DOI] [PubMed] [Google Scholar]
  16. HOFMANN A. F., BORGSTROM B. Physico-chemical state of lipids in intestinal content during their digestion and absorption. Fed Proc. 1962 Jan-Feb;21:43–50. [PubMed] [Google Scholar]
  17. HOFMANN A. F. THE FUNCTION OF BILE SALTS IN FAT ABSORPTION. THE SOLVENT PROPERTIES OF DILUTE MICELLAR SOLUTIONS OF CONJUGATED BILE SALTS. Biochem J. 1963 Oct;89:57–68. doi: 10.1042/bj0890057. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. HOFMANN A. F. The behavior and solubility of monoglycerides in dilute, micellar bile-salt solution. Biochim Biophys Acta. 1963 Jun 18;70:306–316. doi: 10.1016/0006-3002(63)90754-6. [DOI] [PubMed] [Google Scholar]
  19. KNOEBEL L. K., RYAN J. M. Digestion and mucosal absorption of fat in normal and bile-deficient dogs. Am J Physiol. 1963 Mar;204:509–514. doi: 10.1152/ajplegacy.1963.204.3.509. [DOI] [PubMed] [Google Scholar]
  20. MATTSON F. H., BECK L. W. The specificity of pancreatic lipase for the primary hydroxyl groups of glycerides. J Biol Chem. 1956 Apr;219(2):735–740. [PubMed] [Google Scholar]
  21. Moore B., Rockwood D. P. On the Mode of Absorption of Fats. J Physiol. 1897 Feb 5;21(1):58–84. doi: 10.1113/jphysiol.1897.sp000643. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. PALAY S. L., KARLIN L. J. An electron microscopic study of the intestinal villus. I. The fasting animal. J Biophys Biochem Cytol. 1959 May 25;5(3):363–372. doi: 10.1083/jcb.5.3.363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. PALAY S. L., KARLIN L. J. An electron microscopic study of the intestinal villus. II. The pathway of fat absorption. J Biophys Biochem Cytol. 1959 May 25;5(3):373–384. doi: 10.1083/jcb.5.3.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. RAPPORT M. M., ALONZO N. Photometric determination of fatty acid ester groups in phospholipides. J Biol Chem. 1955 Nov;217(1):193–198. [PubMed] [Google Scholar]
  25. REISER R. Recent studies of fat digestion and absorption. Clin Chem. 1955 Apr;1(2):93–104. [PubMed] [Google Scholar]
  26. Vogel W. C., Zieve L. A LECITHINASE A IN DUODENAL CONTENTS OF MAN. J Clin Invest. 1960 Aug;39(8):1295–1301. doi: 10.1172/JCI104146. [DOI] [PMC free article] [PubMed] [Google Scholar]

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