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. 1964 Jun;43(6):1036–1048. doi: 10.1172/JCI104987

Metabolism of Human Gamma Macroglobulins*

Werner F Barth 1, R Dean Wochner 1, Thomas A Waldmann 1, John L Fahey 1
PMCID: PMC289584  PMID: 14170104

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AWAI M., BROWN E. B. Studies of the metabolism of I-131-labeled human transferrin. J Lab Clin Med. 1963 Mar;61:363–396. [PubMed] [Google Scholar]
  2. BAUER D. C., MATHIES M. J., STAVITSKY A. B. Sequences of synthesis of gamma-1 macroglobulin and gamma-2 globulin antibodies during primary and secondary responses to proteins, salmonella antigens, and phage. J Exp Med. 1963 Jun 1;117:889–907. doi: 10.1084/jem.117.6.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BENEDICT A. A., BROWN R. J., HERSH R. T. THE TEMPORAL SYNTHESIS AND SOME CHROMATOGRAPHICAND ULTRACENTRIFUGAL CHARACTERISTICS OF CHICKEN ANTIBODIES. J Immunol. 1963 Mar;90:399–411. [PubMed] [Google Scholar]
  4. BENNHOLD H., KALLEE E. Comparative studies on the half-life of I 131-labeled albumins and nonradioactive human serum albumin in a case of analbuminemia. J Clin Invest. 1959 May;38(5):863–872. doi: 10.1172/JCI103868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. BERSON S. A., YALOW R. S., SCHREIBER S. S., POST J. Tracer experiments with I131 labeled human serum albumin: distribution and degradation studies. J Clin Invest. 1953 Aug;32(8):746–768. doi: 10.1172/JCI102789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. BLAINEY J. D., BREWER D. B., HARDWICKE J., SOOTHILL J. F. The nephrotic syndrome. Diagnosis by renal biopsy and biochemical and immunological analyses related to the response to steroid therapy. Q J Med. 1960 Apr;29:235–256. [PubMed] [Google Scholar]
  7. COHEN S., FREEMAN T. Metabolic heterogeneity of human gamma-globulin. Biochem J. 1960 Sep;76:475–487. doi: 10.1042/bj0760475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. COHEN S., McGREGOR I. A., CARRINGTON S. Gamma-globulin and acquired immunity to human malaria. Nature. 1961 Nov 25;192:733–737. doi: 10.1038/192733a0. [DOI] [PubMed] [Google Scholar]
  9. DRIVSHOLM A. Turnover rate of myeloma proteins in serum and urine determined after intravital labelling with glycine--1--C--14. Acta Med Scand. 1961 May;169:503–507. doi: 10.1111/j.0954-6820.1961.tb07860.x. [DOI] [PubMed] [Google Scholar]
  10. FAHEY F. L., LAWRENCE M. E. QUANTITATIVE DETERMINATION OF 6.6 S GAMMA-GLOBULINS, BETA-2A-GLOBULINS AND GAMMA-1-MACROGLOBULINS IN HUMAN SERUM. J Immunol. 1963 Nov;91:597–603. [PubMed] [Google Scholar]
  11. FAHEY J. L., MCLAUGHLIN C. PREPARATION OF ANTISERA SPECIFIC FOR 6.6 S GAMMA-GLOBULINS, BETA 2A-GLOBULINS, GAMMA-1.-MACROGLOBULINS, AND FOR TYPE I AND II COMMON GAMMA-GLOBULIN DETERMINANTS. J Immunol. 1963 Oct;91:484–497. [PubMed] [Google Scholar]
  12. FAHEY J. L., McCOY P. F., GOULIAN M. Chromatography of serum proteins in normal and pathologic sera: the distribution of protein-bound carbohydrate and cholesterol, siderophilin, thyroxin-binding protein, B12-binding protein, alkaline and acid phosphatases, radio-iodinated albumin and myeloma proteins. J Clin Invest. 1958 Feb;37(2):272–284. doi: 10.1172/JCI103606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. FAHEY J. L., ROBINSON A. G. FACTORS CONTROLLING SERUM GAMMA-GLOBULIN CONCENTRATION. J Exp Med. 1963 Nov 1;118:845–868. doi: 10.1084/jem.118.5.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. FAHEY J. L., SCOGGINS R., UTZ J. P., SZWED C. F. INFECTION, ANTIBODY RESPONSE AND GAMMA GLOBULIN COMPONENTS IN MULTIPLE MYELOMA AND MACROGLOBULINEMIA. Am J Med. 1963 Nov;35:698–707. doi: 10.1016/0002-9343(63)90140-2. [DOI] [PubMed] [Google Scholar]
  15. FINK C. W., MILLER W. E., Jr, DORWARD B., LOSPALLUTO J. The formation of macroglobulin antibodies. II. Studies on neonatal infants and older children. J Clin Invest. 1962 Jul;41:1422–1428. doi: 10.1172/JCI104597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. GABUZDA T. G. The turnover and distribution of I-131-labeled myeloma and macroglobulin proteins. J Lab Clin Med. 1962 Jan;59:65–80. [PubMed] [Google Scholar]
  17. GITLIN D., BORGES W. H. Studies on the metabolism of fibrinogen in two patients with congenital afibrinogenemia. Blood. 1953 Aug;8(8):679–686. [PubMed] [Google Scholar]
  18. GITLIN D., JANEWAY C. A., FARR L. E. Studies on the metabolism of plasma proteins in the nephrotic syndrome. I. Albumin, gamma-globulin and iron-binding globulin. J Clin Invest. 1956 Jan;35(1):44–56. doi: 10.1172/JCI103251. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Humphrey J. H., Fahey J. L. THE METABOLISM OF NORMAL PLASMA PROTEINS AND GAMMA-MYELOMA PROTEIN IN MICE BEARING PLASMA-CELL TUMORS. J Clin Invest. 1961 Sep;40(9):1696–1705. doi: 10.1172/JCI104392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. LIPPINCOTT S. W., KORMAN S., FONG C., STICKLEY E., WOLINS W., HUGHES W. L. Turnover of labeled normal gamma globulin in multiple myeloma. J Clin Invest. 1960 Apr;39:565–572. doi: 10.1172/JCI104069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. LOSPALLUTO J., MILLER W., Jr, DORWARD B., FINK C. W. The formation of macroglobulin antibodies. I. Studies on adult humans. J Clin Invest. 1962 Jul;41:1415–1421. doi: 10.1172/JCI104596. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. McFARLANE A. S. Efficient trace-labelling of proteins with iodine. Nature. 1958 Jul 5;182(4627):53–53. doi: 10.1038/182053a0. [DOI] [PubMed] [Google Scholar]
  23. McFarlane A. S. IN VIVO BEHAVIOR OF I-FIBRINOGEN. J Clin Invest. 1963 Mar;42(3):346–361. doi: 10.1172/JCI104721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. RAUSEN A. R., CRUCHAUD A., McMILLAN C. W., GITLIN D. A study of fibrinogen turnover in classical hemophilia and congenital afibrinogenemia. Blood. 1961 Dec;18:710–716. [PubMed] [Google Scholar]
  25. SOLOMON A., WALDMANN T. A., FAHEY J. L. Clinical and experimental metabolism of normal 6.6s gamma-globulin in normal subjects and in patients with macroglobulinemia and multiple myeloma. J Lab Clin Med. 1963 Jul;62:1–17. [PubMed] [Google Scholar]
  26. STEINFELD J. L., WALDMANN T., DELEA C. S. Metabolism of infused serum albumin in the hypoproteinemia of gastro-intestinal protein loss and in analbuminemia. Trans Assoc Am Physicians. 1961;74:180–194. [PubMed] [Google Scholar]
  27. Sternlieb I., Morell A. G., Tucker W. D., Greene M. W., Scheinberg I. H. THE INCORPORATION OF COPPER INTO CERULOPLASMIN IN VIVO: STUDIES WITH COPPER AND COPPER. J Clin Invest. 1961 Oct;40(10):1834–1840. doi: 10.1172/JCI104407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. TALIAFERRO W. H., TALMAGE D. W. Antibodies in the rabbit with different rates of metabolic decay. J Infect Dis. 1956 Jul-Aug;99(1):21–33. doi: 10.1093/infdis/99.1.21. [DOI] [PubMed] [Google Scholar]
  29. UHR J. W., DANCIS J., FRANKLIN E. C., FINKELSTEIN M. S., LEWIS E. W. The antibody response to bacteriophage phi-X 174 in newborn premature infants. J Clin Invest. 1962 Jul;41:1509–1513. doi: 10.1172/JCI104606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. UHR J. W., FINKELSTEIN M. S. Antibody formation. IV. Formation of rapidly and slowly sedimenting antibodies and immunological memory to bacteriophage phi-X 174. J Exp Med. 1963 Mar 1;117:457–477. doi: 10.1084/jem.117.3.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. WALDMANN T. A. Gastrointestinal protein loss demonstrated by Cr-51-labelled albumin. Lancet. 1961 Jul 15;2(7194):121–123. doi: 10.1016/s0140-6736(61)92646-0. [DOI] [PubMed] [Google Scholar]

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